Skin cancer in non‐white liver transplant recipients: Mayo Clinic experience

Tolaymat, Leila; Reimer, Danielle; Feig, Joshua; Gillis, Melinda S.; Speicher, Leigh; Haga, Claire; Gabriel, Emmanuel; Heckman, Michael G.; Yin, Mingyuan; Fosko, Scott W.; Keaveny, Andrew P.; Dawson, Nancy L.

doi:10.1111/ijd.15519

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…In addition, the role of skin phototype in the NMSC risk for SOTRs remains unclear, as most published studies have included white patients only [ 7 , 8 , 9 ]. A recent study on 96 dark-skinned LTRs reported no NMSC to be detected during a 2-year follow-up, therefore suggesting a significantly lower risk for darker phototypes [ 10 ]. Moreover, in a large prospective study from Iannacone et al, typical NMSC risk factors (ethnicity, skin phototype, previous history of NMSC) were associated with NMSC occurrence after transplantation when considering both liver and kidney transplant recipients [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases

et al. 2022

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Background and Objectives: Solid-organ transplant recipients (SOTRs) are notably considered at risk for developing cutaneous malignancies. However, most of the existing literature is focused on kidney transplant-related non-melanoma skin cancers (NMSCs). Conflicting data have been published so far on NMSC incidence among liver transplant recipients (LTRs), and whether LTRs really should be considered at lower risk remains controversial. The aim of the present study was to prospectively collect data on the incidence of cutaneous neoplasms in an LTR cohort. Materials and Methods: All LTRs transplanted at the Hepato-Pancreato-Biliary Surgery and Liver Transplantation Unit of Modena University Hospital from October 2015 to June 2021 underwent a post-transplant periodic skin check at the Dermatology Unit according to our institutional integrated care pathway. Data on the presence of cutaneous malignant and premalignant lesions were collected at every timepoint. Results: A total of 105 patients were enrolled in the present study. Nearly 15% of the patients developed cutaneous cancerous and/or precancerous lesions during the follow-up period. Almost half of the skin cancerous lesions were basal cell carcinomas. Actinic keratoses (AKs) were observed in six patients. Four patients developed in situ squamous cell carcinomas, and one patient was diagnosed with stage I malignant melanoma. Otherwise, well-established risk factors for the occurrence of skin tumors, such as skin phototype, cumulative sun exposure, and familial history of cutaneous neoplasms, seemed to have no direct impact on skin cancer occurrence in our cohort, as well as an immunosuppressive regimen and the occurrence of non-cutaneous neoplasms. Conclusions: Close dermatological follow-up is crucial for LTRs, and shared protocols of regular skin checks in this particular subset of patients are needed in transplant centers.

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Section: Discussionmentioning

confidence: 99%

De Novo Skin Neoplasms in Liver-Transplanted Patients: Single-Center Prospective Evaluation of 105 Cases

et al. 2022

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“…A preliminary study examining skin cancer in non-White liver transplant recipients at the Mayo Clinic supported the literature indicating that the incidence of de novo malignancy in these patients is low. [9][10][11] The aim of this study was to provide further information describing pre-and posttransplant characteristics and outcomes for patients who were non-White and developed skin cancer following the transplantation of any solid organ at the Mayo Clinic.…”

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confidence: 99%