Skin cancer associated with commonly prescribed drugs: tumor necrosis factor alpha inhibitors (TNF-αIs), angiotensin-receptor blockers (ARBs), phosphodiesterase type 5 inhibitors (PDE5Is) and statins -weighing the evidence

Nardone, Beatrice; Orrell, Kelsey A.; Vakharia, Paras P.; West, Dennis P.

doi:10.1080/14740338.2018.1400530

Cited by 15 publications

(15 citation statements)

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“…Antihypertensive drugs are the most common and widely used drugs among the population; however, according to very new data, they may be associated with an increased risk of melanoma occurrence [1]. As possibly potentiating the development of this type and another type of cutaneous tumours, different groups of drugs for the treatment of arterial hypertension are mentioned [1], [2], [5]. Studies of the carcinogenic effect of angiotensin receptor blockers (ARBs) predominate [2], [3], [4], [5], [5].…”

Section: Discussionmentioning

confidence: 99%

“…As possibly potentiating the development of this type and another type of cutaneous tumours, different groups of drugs for the treatment of arterial hypertension are mentioned [1], [2], [5]. Studies of the carcinogenic effect of angiotensin receptor blockers (ARBs) predominate [2], [3], [4], [5], [5]. It is believed that this group of antihypertensive drugs generally carries a risk of developing cancer [4], but the individual risk of different agents is not yet known [4].…”

Section: Discussionmentioning

confidence: 99%

“…It is believed that this group of antihypertensive drugs generally carries a risk of developing cancer [4], but the individual risk of different agents is not yet known [4]. The prevailing number of data, however, is in the direction of claiming that ARBs are highly associated with melanoma development [2], [3], [5]. In vitro, experimental data show that losartan inhibits NHE1 (Na + /H + exchanger isoform 1) activity and migration of human melanoma cells (MV3), but at the same time stimulates MV3 cell adhesion and invasion [3].…”

Section: Discussionmentioning

confidence: 99%

“…The number of studies, according to which different groups of antihypertensive drugs are likely to potentiate the development of melanoma, increases significantly [1], [2], [3]. According to the literature, angiotensin receptor blockers (ARBs), which are widely used as antihypertensive drugs, carry an increased risk of developing cancer [4].…”

Section: Introductionmentioning

confidence: 99%

“…According to the literature, angiotensin receptor blockers (ARBs), which are widely used as antihypertensive drugs, carry an increased risk of developing cancer [4]. The latest data suggest that the occurrence of cutaneous cancer, including cutaneous melanoma, is also associated with this group of drugs [2], [5]. Experimental in vitro data show that losartan (ARB) stimulates cell adhesion and invasion of human melanoma cells [3].…”

Section: Introductionmentioning

confidence: 99%

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Drug-Induced Melanoma: Irbesartan Induced Cutaneous Melanoma! First Description in the World Literature!

Tchernev¹,

Temelkova²

2019

Open Access Maced J Med Sci

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BACKGROUND:Melanoma appears to be a malignant disease, whose development can be potentiated by different drug groups. More and more data are in favour of the claim that commonly used antihypertensive drugs also contain the risk of developing melanoma. The most evidence is that angiotensin receptor blockers may be carcinogenic. Two representatives from this group, valsartan and irbesartan, produced by certain pharmaceutical companies are being withdrawn from the market due to finding content of NDMA and NDEA, which are believed to be potent carcinogens. Another representative of this group, losartan, according to in vitro data, potentiates cell adhesion and invasion of human melanoma cells.CASE REPORT:We present a 45-year-old man with arterial hypertension. For year and a half/two years, the patient is on systemic therapy with Aspirin and Irbesartan/Hydrochlorothiazide. The patient also reported about the presence of a pigmented lesion in the abdominal area, which occurred 5-6 years ago, before the onset of cardiac therapy. According to him, there was a change in the colour and size of the lesion within the framework of cardiac therapy (from 1.5-2 years). Innovative one step melanoma surgery was performed, and the lesion was radically removed with a 1 cm operational safety margin in all directions within one operative session. The subsequent histological verification found the presence of thin melanoma.CONCLUSION:Drug-induced melanoma turned out to be a problem of significant importance. The group of angiotensin receptor blockers should be investigated more thoroughly and in detail on the probability of potentiating carcinogenesis. We describe an interesting case showing the progression of pigment lesion to melanoma as a possible result of irbesartan therapy, i.e. we share a theory that differs from that of drug-induced de novo melanomas. It should not be overlooked the fact that another widely used drug-Aspirin, is also likely to potentiate the development of melanoma. Furthermore, the case is indicative of the use of one step melanoma surgery in a melanoma patient with a thickness less than 1 mm.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Drug-Induced Melanoma: Irbesartan Induced Cutaneous Melanoma! First Description in the World Literature!

Tchernev¹,

Temelkova²

2019

Open Access Maced J Med Sci

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Trend Analysis of Cutaneous Squamous Cell Carcinoma of the External Lip From 1975 to 2016

Mehta

Nguyen

Chang

et al. 2021

JAMA Otolaryngol Head Neck Surg

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utaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer, with an incidence between 5 and 96 per 100 000 individuals. 1,2 Most patients with this malignant neoplasm are diagnosed early and treated surgically with disease-free survival. However, between 3.7% and 5.8% of cases metastasize, leading to 4000 to 9000 deaths annually in the United States. 3 Cutaneous SCC of the head and neck (cHNSCC) is a primary site of special concern. Commonly affected sites in this region are the external lip and ear. Cutaneous HNSCC accounts for up to 49% to 60% of all cSCC cases, and the anatomical structures of this region predispose to high morbidity with invasive tumors. [4][5][6][7] Analyses of cSCC have found a strong correlation between UV radiation and immunosuppression with disease incidence. 2,5,8,9 These risk factors contribute to the varying in-cidence found within populations, with patients exposed to immunosuppressive drugs or higher UV index more likely to develop this malignant neoplasm. As such, geography is an important risk factor for patients. Individuals living in the more southern regions of the United States have traditionally been targeted as an at-risk group.Localized cases of cSCC are treated surgically, with minimum margins of 4.0 mm (T1) or 6.0 mm (T2) and are curative in 95% of cases. 6 Locally advanced tumors, T3 or greater, are at least 4 cm in size or invade bone or perineural structures. 2 These malignant neoplasms are almost always treated surgically, with either standard excision or Mohs micrographic surgery. Perineural invasion occurs in 2% to 14% of cases, with a high risk of recurrence (47%) and metastasis (35%). 10 Treatment of metastatic disease is multidisciplinary; lymphadenec-IMPORTANCE Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer and commonly affects the head and neck. Increasing regional reports of aggressive cases warrant an analysis of population-based trends of cSCC of the head and neck. OBJECTIVE To assess demographic, clinical, and survival trends among patients with cSCC of the external lip. DESIGN, SETTING, AND PARTICIPANTS This was a retrospective, population-based cohort study of 15 171 cases of cSCC of the external lip registered in the Surveillance, Epidemiology, and End Results (SEER) database between 1975 and 2016. Statistical analyses were conducted in October 2020. MAIN OUTCOMES AND MEASURESThe primary outcome was clinical characteristics (tumor site, stage, and tumor grade). Demographic characteristics, incidence, treatment characteristics, and survival outcomes were also assessed. RESULTSIn total, 15 171 cases of cSCC were extracted from the SEER database (80.3% of patients were male, and 97.0% identified as being of White race/ethnicity). Incidence among male patients decreased from 4.4 to 0.8 per 100 000 during the study period, whereas the female patients' share cases increased from 8.4% in 1975 to 1979 to 26.1% by 2016. Cases increased in the US Pacific Coast and eastern regions, and along...

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Analysis of the expression of cytokines and chemokines, platelet‐leukocyte aggregates, sCD40L and sCD62P in cutaneous melanoma

Santos,

Martins,

Tavares

et al. 2024

Journal of Surgical Oncology

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BackgroundCutaneous melanoma (CM) is a malignancy with a variable incidence worldwide and a poor advanced‐stage prognosis. Melanoma growth is closely associated with the immune system.MethodsA cross‐sectional study was performed on CM patients admitted at the Hospital de Cancer de Pernambuco (HCP) between 2015 and 2018. Fifty‐one CM patients were included, and 30 healthy individuals. The study aimed to evaluate the association of platelet activation mechanisms and inflammatory response in patients with cutaneous melanoma.ResultsElevated serum IL10 and low serum TNF levels in CM patients compared to controls (p < 0.05). High IL6 levels in patients with negative lymph nodes LN (−) compared to positive lymph nodes group (LN +, p = 0.0005). Low RANTES levels in patients compared to controls (p < 0.05). Elevated levels of platelet‐lymphocyte (PLA), platelet‐monocytes (PMA), and platelet‐neutrophils (PNA) aggregates were observed in patients compared to controls (p < 0.05). CM patients with stage II had lower PMA levels than stages I and III (p < 0.05). High PMA levels were observed in patients with LN (+) compared to the LN (‐) group (p < 0.0001). Patients with SSM had high levels of sCD40L and sCD62P compared to controls (p < 0.05)). High sCD40L levels in stage II compared to the stage III group, and sCD62P in stages I and II compared to the stage III group (p < 0.05). High sCD62P levels in patients with LN (‐) compared to the group LN (+) (p < 0.05).ConclusionIt was observed the immunosuppressive profile in CM may favor tumor progression. High levels of platelet‐leukocyte aggregates, sCD40L, and sCD62P may be associated with the worst prognosis.

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Skin cancer associated with commonly prescribed drugs: tumor necrosis factor alpha inhibitors (TNF-αIs), angiotensin-receptor blockers (ARBs), phosphodiesterase type 5 inhibitors (PDE5Is) and statins -weighing the evidence

Cited by 15 publications

References 46 publications

Drug-Induced Melanoma: Irbesartan Induced Cutaneous Melanoma! First Description in the World Literature!

Drug-Induced Melanoma: Irbesartan Induced Cutaneous Melanoma! First Description in the World Literature!

Trend Analysis of Cutaneous Squamous Cell Carcinoma of the External Lip From 1975 to 2016

Analysis of the expression of cytokines and chemokines, platelet‐leukocyte aggregates, sCD40L and sCD62P in cutaneous melanoma

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