Skin burns after laser exposure: Histological analysis and predictive simulation

Museux, Nathanaëlle; Perez, Laetitia; Autrique, Laurent; Agay, Diane

doi:10.1016/j.burns.2011.12.006

Cited by 39 publications

(24 citation statements)

References 21 publications

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“…S8 and S9). These injuries are seen in NIR laser burns (36,37) and set an upper bound on acceptable dosing levels. Such high powers are not required to trigger our devices; however, safer therapies could be achieved by (i) using devices with higher on-state kinetics, which would require shorter irradiation times, (ii) designing devices with a lower on-state irradiation threshold, or (iii) using a pulsed laser source, which also heats nanoparticles but causes less tissue damage (38).…”

Section: Resultsmentioning

confidence: 99%

Near-infrared–actuated devices for remotely controlled drug delivery

Timko

Arruebo

Shankarappa

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

182

175

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A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage to desired effect, with a consequent minimization of toxicity, and could obviate repeated drug administrations or device implantations, enhancing patient compliance. It should exhibit low off-state leakage to minimize basal effects, and tunable on-state release profiles that could be adjusted from pulsatile to sustained in real time. Despite the clear clinical need for a device that meets these criteria, none has been reported to date to our knowledge. To address this deficiency, we developed an implantable reservoir capped by a nanocomposite membrane whose permeability was modulated by irradiation with a near-infrared laser. Irradiated devices could exhibit sustained onstate drug release for at least 3 h, and could reproducibly deliver short pulses over at least 10 cycles, with an on/off ratio of 30. Devices containing aspart, a fast-acting insulin analog, could achieve glycemic control after s.c. implantation in diabetic rats, with reproducible dosing controlled by the intensity and timing of irradiation over a 2-wk period. These devices can be loaded with a wide range of drug types, and therefore represent a platform technology that might be used to address a wide variety of clinical indications.gold | nanoshell | poly(n-isopropylacrylamide) | ethylcellulose | diabetes

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Section: Resultsmentioning

confidence: 99%

Near-infrared–actuated devices for remotely controlled drug delivery

Timko

Arruebo

Shankarappa

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

182

175

View full text Add to dashboard Cite

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“…They highlighted the importance to consider composite structures for skin modelling. Some studies (Jiang et al 2002;Kuznetsov 2007a, 2007b;Museux et al 2012) have reported that the epidermis, the dermis and the hypodermis are solid continuous media in which the heat transfer is controlled by the Pennes equation. To complement the numerical model, the thermal damage is controlled by the Arrhenius' law.…”

Section: Modellingmentioning

confidence: 98%

“…were simulated on different tissues (skin, retinal, liver, etc.). Among these publications, recent numerical approaches (Fuentes et al 2010;Museux et al 2012) gave good predictive results on animal tissues.…”

Section: Introductionmentioning

confidence: 94%

A 3D finite element model for hyperthermia injury of blood-perfused skin

Ratovoson

Huon

Jourdan

2013

Computer Methods in Biomechanics and Biomedical Engineering

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The objective of this study is to propose a numerical model of thermal damage to the skin. This model simulates the propagation of a burn and suggests treatments to prevent it from spreading. In order to achieve this goal, we developed a 3D multi-layer finite element model of the skin coupled with a model presenting hyperthermic damage. The numerical model of the skin takes account of not only the thermal properties of various layers, but also blood perfusion and veins. The model of thermal damage is based on the Arrhenius' law. We tested two various quick intervention treatments so as to prevent the burn from spreading. The first treatment consists of cooling the burned zone with a flow of cool water at 10°C, whereas the second solution simulates the apposition of ice on the burn. The results show that, according to the severity of the burn, the second treatment seems to be the most appropriate. Moreover, our model opens interesting prospects in the analysis of hyperthermic damage.

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“…On the other hand, in the case of dynamic changes of biological properties, He and Bischof [36] proposed a coupled mathematical model between the thermal propagation and the denaturation process of tissues, by means of a correction function, and the degradation of the blood perfusion was incorporated in the thermal analysis. In the same context, the works of Abraham and Sparrow [37] and Museux et al [38], reported the use of similar models considering the manner in which the degradation of blood perfusion is introduced in the thermal analysis, evaluating the blood perfusion for different levels of denaturation. Their results show that the dynamic relationship between temperature and denaturation affects substantially the accumulated thermal denaturation of tissues.…”

Section: Introductionmentioning

confidence: 96%