Skin benefits from continuous topical administration of a zinc oxide/petrolatum formulation by a novel disposable diaper

Baldwin, Sue; Odio, Mauricio; Haines, S L; O’Connor, Robert J.; Englehart, J S; Lane, Alfred T.

doi:10.1046/j.0926-9959.2001.00002.x

Cited by 92 publications

(85 citation statements)

References 18 publications

(19 reference statements)

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“…2 Since ZnO is nontoxic, 3 it is also used as a broadband UV-absorber in pharmaceutical and cosmetic applications [4][5][6][7] or as a diagnostic tool for cancers. 3 Therefore, the high-tech industry is interested in adopting facile and fast synthesis routes for diverse ZnO particles.…”

Section: Introductionmentioning

confidence: 99%

ZnO superstructures via oriented aggregation initiated in a block copolymer melt

Klaumünzer¹,

Distaso²,

Hübner

et al. 2014

CrystEngComm

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A fast and simple one pot synthesis of ZnO nano-and microparticles initiated and driven by an amino block copolymer O,O′-bis(2-aminopropyl)polypropylene glycol-block-polyethylene glycol-block-polypropylene glycol (Jeffamine®) is reported. The specific building mechanism of ZnO mesocrystals is investigated in detail using electron microscopy and diffraction methods. Mesocrystals with a complex superstructure are formed as a result of a consecutive and oriented multiple stage aggregation process: first a 0D → 1D aggregation process is observed, then a 1D → 3D aggregation process occurs in which secondary particles form cones and multiple cone symmetries. Dots, rods, cones, and multiple cones have been isolated within a time resolved study which clearly supports the growth model. To control the morphology of the product particles, the influence of relevant synthesis parameters including stirring and sonication of the intermediate were investigated. Extensive surface characterization of the resulting mesocrystals is presented using infrared and photoluminescence spectroscopies as well as thermogravimetric analysis. Even after multiple washing steps, the particles exhibit a Jeffamine® coated surface that allows for easy dispersion in both polar and nonpolar solvents. The obtained mesocrystals efficiently scatter in the whole range of visible light.

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Section: Introductionmentioning

confidence: 99%

ZnO superstructures via oriented aggregation initiated in a block copolymer melt

Klaumünzer¹,

Distaso²,

Hübner

et al. 2014

CrystEngComm

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“…A emulsão A/O foi preparada através da pesagem dos constituintes da fase oleosa composta por vitamina E (2,94-3,2%, p/v), dimeticona (0,98-1,1%, p/v), Dragosan® (1,96-6,0%, p/v), lanolina (5,3-10,0%, p/v), óleo de fígado de bacalhau (2,7-12,55%, p/v) e vaselina branca (19,(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21),4%, p/v) (7)(8)(9) . Estes componentes foram dissolvidos num banho de água a 65ºC e misturados lentamente.…”

Section: A) Produção Da Emulsão A/ounclassified

“…After cooling the temperature to 60°C, chamomile (0.49 -0.52%, w/v) and aloe vera extracts (4.9 -5.3%, w/v) were added (4)(5)(6)11,12) . In a pre-heated (60 °C) mortar, corn starch (14.7 -16.0 %, w/v), titanium oxide (1.5 -1.6%, w/v) and zinc oxide (14.7 -16.0%, w/v) were added (7,9,13) , after which the W/O emulsion was homogenized and packaged. Thirteen formulations were prepared according to Table 1.…”

Section: A) Production Of W/o Emulsionmentioning

confidence: 99%

“…A W/O emulsion was prepared by weighing the constituents of the oily phase containing vitamin E acetate (2.94 -3.2%, w/v), dimethicone (0.98 -1.1%, w/v), Dragosan® (1.96 -6.00%, w/v), lanolin (5.3 -10.0%, w/v), cod liver oil (2.7 -12.55%, w/v) and white petroleum (19.6 -21.4%, w/v) (7)(8)(9) . These components were melted in a water bath at 65 °C and slowly mixed.…”

Section: A) Production Of W/o Emulsionmentioning

confidence: 99%

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A novel topical association with zinc oxide, chamomile and aloe vera extracts - stability and safety studies

Reis

Antunes

Rijo

et al. 2015

BBR

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Biopharmaceutical Sciences│Ciências BiofarmacêuticasBiomed Biopharm Res. , 2015; (12) 2: , 251-264 251 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c aA novel topical association with zinc oxide, chamomile and aloe vera extractsstability and safety studies AbstractCurrently, natural products show an enormous potential for pharmaceutical and cosmetic industries. The goals of this study were to formulate and to characterise a novel combination of natural products. Formulations were 1) an oil-in-water emulsion, 2) a water-in-oil emulsion and 3) a cleansing solution. Zinc oxide was chosen as an active ingredient due to its healing properties, and chamomile and aloe vera extracts were chosen due to their antiseptic, anti-inflammatory and tissue regenerating properties. Organoleptic characteristics, pH, viscosity and in vitro efficacy for the most common bacteria and yeast of human skin were evaluated. Preliminary and accelerated stability studies and safety tests were also performed. All optimized products were stable, smooth in texture, effective against bacteria and yeast, and safe, justifying further studies. Results suggest that these novel products might be a promising source of natural compounds with soothing and regenerative properties for skin care.Keywords: Chamomilla recutita; Aloe vera; Zinc Oxide; Topical formulations; Skin. Resumo:Atualmente, os produtos naturais apresentam um enorme potencial para as indústrias farmacêuticas e cosméticas. Os objetivos deste estudo foram a formulação e a caracterização de três cosméticos contendo produtos naturais. As formulações foram: 1) emulsão óleo-em-água; 2) emulsão água-em-óleo e 3) solução de limpeza. O óxido de zinco foi escolhido como ingrediente ativo devido às suas propriedades regenerativas e os extratos de aloe vera e camomila devido às suas propriedades antissépticas, anti-inflamatórias e também regenerativas. Os parâmetros avaliados foram as características organoléticas, pH, viscosidade e a eficácia in vitro contra bactérias e fungos comuns em doenças de pele. Foram igualmente efetuados estudos preliminares e acelerados de estabilidade e segurança. Todos os produtos demonstraram estabilidade, textura suave, eficácia contra bactérias e fungos e segurança, justificando estudos adicionais. Os resultados obtidos sugerem que estes novos produtos poderão ser uma fonte promissora de produtos naturais com propriedades calmante e regenerativa para a pele.

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“…As most of the parent does not see the diaper dermatit as a disease, and most of the 0 -18 month old 0 -18 month old children are treated at homes the proper prevalence is unknown [4,5]. In different researches done in other countries the diaper dermatit prevalence is changes between 15.2% and 60.3% [1,6,7] In our country (Turkey) the prevalence is between 23.9% and 61.5% [8,9].…”

Section: Introductionmentioning

confidence: 99%

The effect of protective genital care protocol on preventing diaper dermatit development in 0 - 18 month old children using antibiotics

Baran¹,

Çimen²

2013

OJN

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Diaper dermatit is among the widely seen inflamatory skin diseases in neonatals and small 0 -18 month old children. Control of causative agents as well as providing good genital care may prevent or reduce the risk of the disease. The aim of this study is find out the effect of protective genital care on reducing the diaper dermatit development in 0 -18 months old inpatient 0 -18 month old children who are using antibiotic. The study was conducted as prospective halfexperimetal using control-experimental groups. Our samples comprise of 0 -18 month old children admitted at Dokuz Eylul University Practical and Research Hospital, pediatric clinic between January and May 2009, 41 0 -18 month old children as a control group were not under protective genital care, and 42 0 -18 month old children as an experimental group were under the protecion and using vaseline. The mothers of the experimental group 0 -18 month old children were given education. All 0 -18 month old children were followed-up 3 -7 days and the collected data were evaluated in computer using Pearson's chisquare, Fisher's exact chi-square and Yatest-corrected chi-square tests. The diaper dermatit development ratio was 34.1% in the control group and 7.1% in the experimental group (p < 0.05). The rash disease in most of the control group 0 -18 month old children developed in 2 -3 days earlier than those in experimental group which appeared after the fourth day of study. All the 0 -18 month old children with diaper dermatit in the experimental group were found to be with first grade diaper dermatit while those with diaper dermatit in the control group were found to be with second and third grade diaper dermatit. The Diaper dermatit development ratio between the experiment group who were given the protective genital care and vaseline was meaningfully low in comparison to the control group who were not given any care.And those who acquired diaper dermatit disease among experiment group 0 -18 month old children the disease appeared in late days and was rather mild. As the diaper dermatit was found to be more frequent in 0 -18 month old children on antibiotics, to prevent the occurence of the disease proper protective genital care, vaseline use whenever the diaper is changed and giving education to mothers on the subject concerned is advised.

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Skin benefits from continuous topical administration of a zinc oxide/petrolatum formulation by a novel disposable diaper

Abstract: The results demonstrated the clinical benefits associated with continuous topical administration of a zinc oxide/petrolatum-based formulation by this novel diaper.

Cited by 92 publications

References 18 publications

ZnO superstructures via oriented aggregation initiated in a block copolymer melt

ZnO superstructures via oriented aggregation initiated in a block copolymer melt

A novel topical association with zinc oxide, chamomile and aloe vera extracts - stability and safety studies

The effect of protective genital care protocol on preventing diaper dermatit development in 0 - 18 month old children using antibiotics

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