Skin Bank Bioproducts: The Basics

Tognetti, Linda; Ierardi, Francesca; Mariotti, G; Petruzzelli, Angela; Pompella, Gerarda; Fimiani, Michele; Rubegni, Pietro; Pianigiani, Elisa

doi:10.1007/978-3-030-45351-0_41

Cited by 1 publication

(10 citation statements)

References 29 publications

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“…Since burn damage causes a temporary depression of the immune system in the lesional area, viable tissue, either dermal and epidermal, has been traditionally preferred since the beginning of allografting 6,40,45,46 . The consensus among tissue banks that deep‐frozen/cryopreserved viable tissue grafts should be used for burns, lasted for decades 4,5 . This also because the transient immunodepression allowed the partial integration of meshed hypo‐cellulated dermal allografts into the wound bed 6,9,40,45,46 .…”

Section: Burnsmentioning

confidence: 99%

“…6,40,45,46 The consensus among tissue banks that deep-frozen/cryopreserved viable tissue grafts should be used for burns, lasted for decades. 4,5 This also because the transient immunodepression allowed the partial integration of meshed hypo-cellulated dermal allografts into the wound bed. 6,9,40,45,46 More recently, the introduction of hADMs has provided a non-immunogenic structure to be used in those patients.…”

Section: Burnsmentioning

confidence: 99%

“…A relevant quote of HHWs is defined “full‐thickness”, determined by an injury causing the loss of the whole dermal compartment. Since the human body is unable to spontaneously regenerate into the normal dermis in vivo, but produces a scar, 3‐6 the gold standard for permanent closure of a full‐thickness wound is the autologous grafting: however, this is not realizable in the majority of cases, due to the extension of the damaged skin area and the patient comorbidities 1‐6 . On the other hand, we are currently able to enhance an at least partial “dermal regeneration” by providing specific substrates that stimulate the wound bed.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5]7,8 Therefore, tissue engineering research recently focused its attention on optimizing the complete removal of the cellular component from animal or human dermal tissues. [1][2][3][4][5][6][7][8] A properly designed decellularization process allows to preserve the structural integrity of the tissue, ensuring the regeneration of an intact vasculature, resulting in human or biological acellular dermal matrices (ADMs). Given that, human acellular dermal matrices (hADMs) meet the criteria of an "ideal scaffold", defined as a substrate which is properly recognized by host cells and is fully incorporated by the host tissue after grafting.…”

mentioning

confidence: 99%

“…11 On the other hand, outside the European Community, hADMs can be commercialized as medical devices, can be produced and sold by Commercial Companies. 4,5,9,11 The present review aims to illustrate the main body of experience reported on the use of hADMs in the different surgical and clinical settings, and discuss the peculiar advantages reached with their use compared with the biologic, synthetic and semi-synthetic ADMs.…”

mentioning

confidence: 99%

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The use of human acellular dermal matrices in advanced wound healing and surgical procedures: State of the art

Tognetti

Pianigiani

Ierardi

et al. 2021

Dermatologic Therapy

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Wound closure after post-traumatic injuries and/or localized at peculiar body sites (head-and-neck, oral cavity, legs) are particularly challenging and can often be delayed due to local and systemic factors. In case of deep wounds and/or hard-to-heal wounds, grafting of dermal acellular matrices (ADM) is often needed. Though a great variety of synthetic and semisynthetic dermal and skin equivalents are available, viable human dermis, is still considered the most physiological alternative to replace the loss of autologous dermis, by acting as a physiological scaffold that add structural support to soft tissues. To date, human ADMs (hADMs) have been employed in the reconstruction of skin defects affecting almost all body sites, ranging from visceral sites to the skin and subcutaneous tissues. This review aims to investigate the use of hADM at different body sites and their peculiar advantages. A literature search was using the search terms "acellular dermal matrices", "dermal regeneration", "advances wound healing", "human acellular dermal matrices surgery". A total of 50 out of 150 papers was included. Based on the current body if evidence, hADMs appear to bring several advantages, such as: protection of deep structures (eg, tendons, bones, cartilage and nerves); stimulation of a functional new dermis (rather than a scar); reduction of wound closure time; control of pain and exudate. Finally, hADMs may represent the best treatment option for hard-to-heal wound not only in terms of efficacy and patient satisfaction bout also in terms of sanitary costs, especially across Europe, where hADMs cannot be commercialized as medical devices.

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Section: Burnsmentioning

confidence: 99%