“…Intrinsic risk factors are: age extremes, comorbidities (for example atopic dermatitis, epidermolysis bullosa, ectodermal dysplasia, psoriasis, diabetes, vascular diseases, infection, kidney failure, immunosuppression, rheumatoid arthritis, venous hypertension, peristomal varicose veins), dehydration, nutritional deficit, edema, exposure to free radicals, mental disorders (for example stress and anxiety), less pigmentation skin, reduced mobility, and female sex. Extrinsic risk factors are: extremes of humidity, prolonged use of medications (for example corticosteroids, chemotherapy, anti-inflammatories, anticoagulants), radiotherapy, exposure to ultraviolet radiation, repeated removal of adhesives, inappropriate use of adhesives, creams and devices, obesity, cachexia, smoking, excessive cold or heat, friction and pressure on the skin, use of products that increase the adhesion of adhesives, excessive bathing, use of inappropriate cleaning products, and history of injury ( Bryant, 1988 ; Cutting, 2008 ; Fumarola et al., 2020 ; Hill and Moureau, 2019 ; Hunt, 2016 ; Jones, 2017 ; LeBlanc and Baranoski, 2011 ; ( Liu et al., 2013 ); McNichol et al., 2013 ; McNichol and Bianchi, 2016 ; Morgan, 1981 ; Roberts, 2007 ).…”