Skin autofluorescence photo-bleaching and photo-memory

Lesins, Janis; Lihache, Alexey; Rudys, Romualdas; Bagdonas, Saulius; Spīgulis, Jānis

doi:10.1364/ecbo.2011.80920n

Cited by 5 publications

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“… Skin autofluorescence photobleaching at continuous 532nm laser irradiation (~85 mW/cm 2 ): ( a )—temporal changes of the emission spectrum [ 36 ]; ( b )—partial recovery of the autofluorescence intensity at two wavelengths after interrupted excitation [ 37 ]. …”

Section: Figurementioning

confidence: 99%

Multispectral, Fluorescent and Photoplethysmographic Imaging for Remote Skin Assessment

Spīgulis

2017

Sensors

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Optical tissue imaging has several advantages over the routine clinical imaging methods, including non-invasiveness (it does not change the structure of tissues), remote operation (it avoids infections) and the ability to quantify the tissue condition by means of specific image parameters. Dermatologists and other skin experts need compact (preferably pocket-size), self-sustaining and easy-to-use imaging devices. The operational principles and designs of ten portable in-vivo skin imaging prototypes developed at the Biophotonics Laboratory of Institute of Atomic Physics and Spectroscopy, University of Latvia during the recent five years are presented in this paper. Four groups of imaging devices are considered. Multi-spectral imagers offer possibilities for distant mapping of specific skin parameters, thus facilitating better diagnostics of skin malformations. Autofluorescence intensity and photobleaching rate imagers show a promising potential for skin tumor identification and margin delineation. Photoplethysmography video-imagers ensure remote detection of cutaneous blood pulsations and can provide real-time information on cardiovascular parameters and anesthesia efficiency. Multimodal skin imagers perform several of the abovementioned functions by taking a number of spectral and video images with the same image sensor. Design details of the developed prototypes and results of clinical tests illustrating their functionality are presented and discussed.

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Section: Figurementioning

confidence: 99%

Multispectral, Fluorescent and Photoplethysmographic Imaging for Remote Skin Assessment

Spīgulis

2017

Sensors

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“…a b Figure 8. Skin autofluorescence photobleaching at continuous 532nm laser irradiation (10-85 mW/cm 2 ): a -temporal changes of the emission spectrum [36], b -partial recovery of the autofluorescence intensity after interrupted excitation [37].…”

Section: Prototype Device For Skin Fluorescence Imaging With a Smartpmentioning

confidence: 99%

Multispectral, Fluorescent and Photoplethysmographic Imaging for Remote Skin Assessment

Spīgulis¹

2017

Preprint

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Optical tissue imaging has several advantages over the routine clinical imaging methods, including non-invasiveness (does not change the structure of tissues), remote operation (avoids infection) and ability to quantify the tissue condition by means of specific image parameters. Dermatologists and other skin experts need compact (preferably pocket-size), self-sustained and easy-to-use imaging devices. The operational principles and designs of ten portable in-vivo skin imaging prototypes developed at the Biophotonics Laboratory of Institute of Atomic Physics and Spectroscopy, University of Latvia during the recent five years are presented in this paper. Four groups of imaging devices are considered. Multi-spectral imagers offer possibilities for distant mapping of specific skin parameters, so facilitating better diagnostics of skin malformations. Autofluorescence intensity and photobleaching rate imagers show a promising potential for skin tumor identification and margin delineation. Photoplethysmography video-imagers ensure remote detection of cutaneous blood pulsations and can provide real-time information on cardiovascular parameters and anesthesia efficiency. Multimodal skin imagers perform several of the above-mentioned functions by taking a number of spectral and video images with the same image sensor. Design details of the developed prototypes and results of clinical tests illustrating their functionality are presented and discussed.

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“…Autofluorescence (AF) and diffuse reflectance (DR) imaging using light emitting diode (LED) illumination has been in use since the 2010s [25] and has previously been utilized to visualize different skin conditions [26][27][28]. A multispectral LED-based device prototype was successfully tested in the assessment of skin cancer and the detection of recurrence in post-operative scars [27,29].…”

Section: Introductionmentioning

confidence: 99%

Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum

et al. 2021

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Pseudoxanthoma elasticum (PXE) is a rare multisystemic autosomal recessive connective tissue disease. In most cases, skin manifestations of PXE are the first to develop, followed later by severe ocular and cardiovascular complications. In our present study, in addition to dermoscopy, we introduced novel techniques, autofluorescence (AF) and diffuse reflectance (DR) imaging for the assessment of affected skin sites of five PXE patients. PXE-affected skin areas in most skin sites showed a previously observed pattern upon dermoscopic examination. With the novel imaging, PXE-affected skin lesions displayed high AF intensity. During our measurements, significantly higher mean, minimum and maximum AF intensity values were found in areas of PXE-affected skin when compared to uninvolved skin. Conversely, images acquired with the use of 660 and 940 nm illumination showed no mentionable difference. Our results demonstrate that AF imaging may be used in the in vivo diagnostics and quantification of the severity of the skin lesions of PXE patients. In addition, it is a safe, fast and cost-effective diagnostic method. AF imaging may be also used to objectively monitor the efficacy of the possible novel therapeutic approaches of PXE in the future.

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Skin autofluorescence photo-bleaching and photo-memory

Cited by 5 publications

References 0 publications

Multispectral, Fluorescent and Photoplethysmographic Imaging for Remote Skin Assessment

Multispectral, Fluorescent and Photoplethysmographic Imaging for Remote Skin Assessment

Multispectral, Fluorescent and Photoplethysmographic Imaging for Remote Skin Assessment

Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum

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