Skin autofluorescence is associated with progression of kidney disease in type 2 diabetes: A prospective cohort study from the Hong Kong diabetes biobank

Lau, Eric S. H.; Luk, Andrea; Ozaki, Risa; Chow, Elaine; So, Tammy; Yeung, Theresa; Loo, Kit-Man; Lim, CL; Kong, Alice P.S.; So, Wing Yee; Jenkins, Alicia J.; Chan, Juliana C.N.; Ronald, C.

doi:10.1016/j.numecd.2021.10.007

Cited by 15 publications

(13 citation statements)

References 48 publications

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“…The Hong Kong Diabetes Biobank (HKDB) is a multicenter prospective cohort study coordinated by the Prince of Wales Hospital (PWH), the teaching hospital of the Chinese University of Hong Kong [ 23 – 25 ]. It is based on a similar design to the Hong Kong Diabetes Register (established at PWH since 1995), a quality-improvement program incorporating comprehensive and structured assessments of risk factors and diabetes complications and in which patients were consented for prospective follow-up and archiving of biospecimens for research purpose [ 26 ].…”

Section: Methodsmentioning

confidence: 99%

“…Initiated in 2014, HKDB enrolled participants from 11 diabetes centers at major public hospitals across Hong Kong using similar enrollment and assessment methods, aiming to establish a multicenter diabetes register and biobank for biomarker discovery. All participants were invited to take part in the study when attending a scheduled and standardized diabetes complications assessment and the recruitment methods, collection of anthropometric, lifestyle factors, biochemical investigations, and blood samples for research purpose have been detailed previously [ 23 – 25 ]. Once enrolled, participants will be followed till death.…”

Section: Methodsmentioning

confidence: 99%

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High-density lipoprotein subclasses and cardiovascular disease and mortality in type 2 diabetes: analysis from the Hong Kong Diabetes Biobank

Lau

Luk

Tam

et al. 2022

Cardiovasc Diabetol

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Objective High-density lipoproteins (HDL) comprise particles of different size, density and composition and their vasoprotective functions may differ. Diabetes modifies the composition and function of HDL. We assessed associations of HDL size-based subclasses with incident cardiovascular disease (CVD) and mortality and their prognostic utility. Research design and methods HDL subclasses by nuclear magnetic resonance spectroscopy were determined in sera from 1991 fasted adults with type 2 diabetes (T2D) consecutively recruited from March 2014 to February 2015 in Hong Kong. HDL was divided into small, medium, large and very large subclasses. Associations (per SD increment) with outcomes were evaluated using multivariate Cox proportional hazards models. C-statistic, integrated discrimination index (IDI), and categorial and continuous net reclassification improvement (NRI) were used to assess predictive value. Results Over median (IQR) 5.2 (5.0–5.4) years, 125 participants developed incident CVD and 90 participants died. Small HDL particles (HDL-P) were inversely associated with incident CVD [hazard ratio (HR) 0.65 (95% CI 0.52, 0.81)] and all-cause mortality [0.47 (0.38, 0.59)] (false discovery rate < 0.05). Very large HDL-P were positively associated with all-cause mortality [1.75 (1.19, 2.58)]. Small HDL-P improved prediction of mortality [C-statistic 0.034 (0.013, 0.055), IDI 0.052 (0.014, 0.103), categorical NRI 0.156 (0.006, 0.252), and continuous NRI 0.571 (0.246, 0.851)] and CVD [IDI 0.017 (0.003, 0.038) and continuous NRI 0.282 (0.088, 0.486)] over the RECODe model. Conclusion Small HDL-P were inversely associated with incident CVD and all-cause mortality and improved risk stratification for adverse outcomes in people with T2D. HDL-P may be used as markers for residual risk in people with T2D.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

High-density lipoprotein subclasses and cardiovascular disease and mortality in type 2 diabetes: analysis from the Hong Kong Diabetes Biobank

Lau

Luk

Tam

et al. 2022

Cardiovasc Diabetol

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“…Although glycated hemoglobin (HbA1c), an Amadori rearrangement product formed by hemoglobin binding to glucose in red blood cells, has been demonstrated to be a reliable prognostic marker in the general diabetic population, it may not be effective in diabetes patients with chronic renal impairment [ 82 ]. Table 3 gives an overview of human studies investigating the role of AGEs and sRAGE in DN [ 6 , 34 , 35 , 36 , 83 , 84 , 85 , 86 , 87 ].…”

Section: Diabetic Nephropathymentioning

confidence: 99%

“…After controlling for risk variables such as baseline eGFR and uACR, SAF was linked to kidney disease progression and yearly drop in eGFR. Reduced eGFR (12.9%) and increased uACR (25.8%) accounted for 38.7% of the effect of SAF on renal outcome [ 87 ].…”

Section: Diabetic Nephropathymentioning

confidence: 99%

The Role of Advanced Glycation End Products and Its Soluble Receptor in Kidney Diseases

Steenbeke

Speeckaert

Desmedt

et al. 2022

IJMS

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Patients with chronic kidney disease (CKD) are more prone to oxidative stress and chronic inflammation, which may lead to an increase in the synthesis of advanced glycation end products (AGEs). Because AGEs are mostly removed by healthy kidneys, AGE accumulation is a result of both increased production and decreased kidney clearance. On the other hand, AGEs may potentially hasten decreasing kidney function in CKD patients, and are independently related to all-cause mortality. They are one of the non-traditional risk factors that play a significant role in the underlying processes that lead to excessive cardiovascular disease in CKD patients. When AGEs interact with their cell-bound receptor (RAGE), cell dysfunction is initiated by activating nuclear factor kappa-B (NF-κB), increasing the production and release of inflammatory cytokines. Alterations in the AGE-RAGE system have been related to the development of several chronic kidney diseases. Soluble RAGE (sRAGE) is a decoy receptor that suppresses membrane-bound RAGE activation and AGE-RAGE-related toxicity. sRAGE, and more specifically, the AGE/sRAGE ratio, may be promising tools for predicting the prognosis of kidney diseases. In the present review, we discuss the potential role of AGEs and sRAGE as biomarkers in different kidney pathologies.

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“…Independent associations of SAF existed with CVE (hazard ratio 1.18/SD, 95% CI 1.02–1.37), coronary heart disease (hazard ratio 1.29/SD, 95% CI 1.02–1.63), and congestive heart failure (hazard ratio 1.53/SD, 95% CI 1.14-2.05). In another article about this same cohort, SAF was associated with progression of kidney disease (source for both studies: A prospective cohort study from the Hong Kong diabetes biobank), as reported by Jin et al [9 ▪ ].…”

Section: Relation Between Skin Autofluorescence and Microvascular And...mentioning

confidence: 82%

Skin autofluorescence as tool for cardiovascular and diabetes risk prediction

Smit

Zande

Mulder

2022

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of reviewAdvanced glycation endproducts (AGE) have an important role in the development of chronic complications in diabetes mellitus and in renal failure. Skin autofluorescence (SAF) is a simple noninvasive optical technique to estimate AGE levels in the dermis. SAF increases with age, but rises more rapidly in diabetes and renal failure, and is also associated with, and a predictor of their complications. Recent findingsIn recent large population studies, SAF is a strong predictor of development of type 2 diabetes (T2D), and in persons with known diabetes of its complications. SAF also predicts new cardiovascular disease (CVD) and mortality not only in individuals with known type 2 diabetes but also in the general population. SummarySAF is a simple, powerful and independent predictor for development of type 2 diabetes (T2D), and also for cardiovascular disease and mortality in both persons with diabetes, and in the general population.

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Skin autofluorescence is associated with progression of kidney disease in type 2 diabetes: A prospective cohort study from the Hong Kong diabetes biobank

Cited by 15 publications

References 48 publications

High-density lipoprotein subclasses and cardiovascular disease and mortality in type 2 diabetes: analysis from the Hong Kong Diabetes Biobank

High-density lipoprotein subclasses and cardiovascular disease and mortality in type 2 diabetes: analysis from the Hong Kong Diabetes Biobank

The Role of Advanced Glycation End Products and Its Soluble Receptor in Kidney Diseases

Skin autofluorescence as tool for cardiovascular and diabetes risk prediction

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