Skin autofluorescence, a measure of tissue accumulation of advanced glycation end products, is associated with subclinical atherosclerosis in coronary and carotid arteries

Pan, Jingxue; Bao, Xue; Gonçalves, Isabel; Jujić, Amra; Engström, Gunnar

doi:10.1016/j.atherosclerosis.2022.02.014

Cited by 6 publications

(4 citation statements)

References 46 publications

(78 reference statements)

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“…The method to measure skin autofluorescence AGE has been widely used in many studies [26–28]. sfAGE measures a mixture of several AGEs, and it has been documented by Almengló et al [28] to be advantageous and more convenient for practical reasons.…”

Section: Discussionmentioning

confidence: 99%

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Associations between birth parameters and skin autofluorescence advanced glycation end products and ankle–brachial index in young adulthood: the Malmö Offspring Study

Sharma

Sperling

Jujić

et al. 2023

Journal of Hypertension

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Background:Low birth weight (LBW), advanced glycation end-products (AGE), and ankle–brachial index (ABI) have all been independently associated with risk of cardiovascular disease. Evidence is lacking on the effect of LBW on adult AGE, a marker of glucose metabolism, and ABI, a marker of peripheral atherosclerosis. The objective was to study these associations in a population-based cohort.Methods:Data from the Malmö Offspring Study, Sweden, were used for 2012 participants (958 men, 1054 women) born between 1973 and 2000, linked to the Medical Birth Register. General linear regression analysis (with β coefficients and 95% confidence intervals) was applied for associations between birth weight and skin auto-fluorescence (sf)AGE as well as mean ABI (right/left), before and after adjusting for gestational age, sex, glucose, lipids, smoking, BMI and SBP.Results:The mean (SD) age of men was 29.3 (7.3) and of women 28.6 (7.3) years. There was an average 0.054 decrease in sfAGE value per 1 kg increase in birth weight (adjusted for gestational age and sex). Similarly, 1 kg increase in birth weight (adjusted for gestational age and confounders) was associated with an average 0.016 decrease in mean ABI.Conclusion:Birth weight, adjusted for gestational age and other confounding variables, is inversely associated with ABI in young adulthood, an age range when ABI may represent hemodynamic changes more than atherosclerosis, but for sfAGE, the association was attenuated upon further adjustment. These risk markers may, therefore, represent mediating pathways for early life factors affecting cardiovascular risk later in life.

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Section: Discussionmentioning

confidence: 99%

“…The method to measure skin autofluorescence AGE has been widely used in many studies [26][27][28]. sfAGE measures ABI is as a marker of subclinical atherosclerosis, especially in the elderly [29].…”

Section: Discussionmentioning

confidence: 99%

Associations between birth parameters and skin autofluorescence advanced glycation end products and ankle–brachial index in young adulthood: the Malmö Offspring Study

Sharma

Sperling

Jujić

et al. 2023

Journal of Hypertension

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“…Autofluorescence was calculated by automated off-line analysis. The mean of three values was recorded and used in the analysis [ 5 ].…”

Section: Methodsmentioning

confidence: 99%

“…Advanced glycation end products (AGEs) are potentially toxic proteins that become glycated after contact with sugars [ 3 ], and are established risk marker in diabetic vascular disease, and associated with the degree of diabetes complications, renal failure, and atherosclerosis [ 4 , 5 ]. By formation of crosslinking and modification of extracellular matrix proteins, AGEs modulate the mechanical properties of the target tissue, causing reduced elasticity and flexibility, thereby promoting arterial stiffness [ 6 ], as a marker of early vascular ageing (EVA).…”

Section: Introductionmentioning

confidence: 99%

Accumulation of advanced glycation end products in skin and increased vascular ageing in the general population: the Malmö Offspring Study

Jujic,

Engström,

Nilsson

et al. 2023

Journal of Hypertension

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Objectives: Advanced glycation end product (AGE) is an established risk marker for diabetic vascular disease, and associated with the degree of diabetes complications, renal failure, and atherosclerosis in middle-aged and older individuals. The relationship between AGEs and aortic stiffness has not been thoroughly examined in the younger general population. We aimed to evaluate the association between AGEs and aortic stiffness in the general population of young and middle-aged adults. Methods: We analysed cross-sectionally 2518 participants from a Swedish population-based cohort, the Malmö Offspring Study (mean age 41.8 ± 14.5 years, 52.2%). Advanced glycation end-products (AGEs) were measured by a well validated, noninvasive method using skin autofluorescence with AGE-Reader. Aortic stiffness was assessed by carotid–femoral pulse wave velocity (PWV) and augmentation index (Aix) was calibrated to a standard heart rate of 75 bpm at the arteria radialis using SphygmoCor. Multivariable linear regression was performed stratified by age to analyse the association between skin AGE and aortic stiffness. Results: Increased levels of AGEs were significantly associated with higher direct measurements of aortic stiffness (vascular ageing) in younger individuals (PWV β 0.55 m/s, P < 0.001) after adjustment for traditional cardiometabolic risk factors, however, not in older individuals (PWV β 0.23 m/s, P = 0.10). Indirect vascular ageing was also significantly associated with higher levels of AGEs in both younger (Aix β 7.78, P < 0.001) and older individuals (Aix β 3.69, P < 0.001). Conclusion: Higher levels of skin autofluorescence-AGEs are positively associated with increased vascular ageing in younger adults from the general population, independent of cardiometabolic risk factors.

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Clinical significance of skin autofluorescence for diabetic macroangiopathy and comparison with conventional markers of atherosclerosis: a cross-sectional and prospective study

et al. 2022

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Skin autofluorescence, a measure of tissue accumulation of advanced glycation end products, is associated with subclinical atherosclerosis in coronary and carotid arteries

Cited by 6 publications

References 46 publications

Associations between birth parameters and skin autofluorescence advanced glycation end products and ankle–brachial index in young adulthood: the Malmö Offspring Study

Associations between birth parameters and skin autofluorescence advanced glycation end products and ankle–brachial index in young adulthood: the Malmö Offspring Study

Accumulation of advanced glycation end products in skin and increased vascular ageing in the general population: the Malmö Offspring Study

Clinical significance of skin autofluorescence for diabetic macroangiopathy and comparison with conventional markers of atherosclerosis: a cross-sectional and prospective study

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