Skin as a site of metastasis

Aldret, Stephanie; Cotton, Lora

doi:10.1016/j.osfp.2011.09.005

Cited by 5 publications

(12 citation statements)

References 16 publications

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“…In the majority of cases, abundant cytoplasmic glycogen can be demonstrated by periodic acid Schiff staining, which is negative in blastemal elements. Cells are WT1 negative, but FLI 1 is invariably positive 11 . Ewing's/PNET may be the closest mimicker of a blastemal predominant WT, as in our case.…”

Section: Discussionsupporting

confidence: 59%

“…Immunocytochemically, the negativity for Desmin and PanCK will help rule out a DSRCT as WT‐1 will be positive in both Blastemal WT and DSRCT. Also, the diagnosis can be confirmed by demonstrating the EWS‐WT1 t(11;22)(q13;q12)translocation 11 …”

Section: Discussionmentioning

confidence: 96%

“…In such a case, the aspirate smears show uniformly dispersed cells with scanty deep blue cytoplasm and abundant mitotic figures and apoptotic bodies. Lymphoglandular bodies may be present in the background, which can be a useful diagnostic clue 11 …”

Section: Discussionmentioning

confidence: 99%

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Cutaneous metastasis in a case of Wilm's tumor diagnosed on cytology ‐ A rare case report

Paruvathavarthini

Stephen

et al. 2020

Diagnostic Cytopathology

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A 12‐year‐old male child presented with complaints of a slow growing swelling in the right parasternal region noticed since one month. On examination, the lump was 2 × 2 cm firm, mobile nontender located in the subcutaneous plane which was also confirmed radiologically. Fine needle aspiration cytology was attempted showed small to medium sized monotonous round cell morphology, nuclear molding and mitotic figures were frequent. Few cells exhibiting rosettoid arrangement. No definite epithelial or mesenchymal component was evident. No glio‐fibrillary matrix or lymphoglandular bodies were evident in the smears. Based on morphology, a small round cell tumor was considered with possibilities of Wilm's tumor and Ewing's family of tumor. Based on morphological differentials ICC was requested, tumor cells were positive for strong nuclear WT1 staining while CK and FLI1 were negative. The cytomorphology along with the ICC confirmed the diagnosis of metastatic wilm's tumor. Seven years back, patient had a history of nephrectomy, which on histopathology was reported as triphasic Wilms tumor with favorable histology. Generally Wilm's tumor recurs within 2 years of diagnosis. Late recurrence in Wilm's tumor is rare with only a handful of case reports. Common sites for metastasis include lung, liver, contralateral kidney. Cutaneous metastasis is very uncommon, early detection of which with helps in therapeutic and prognostic decisions. The interesting aspect of this article is cytological detection of cutaneous metastasis of late recurrence Wilm's tumor, which is extremely rare to occur.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 96%

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Cutaneous metastasis in a case of Wilm's tumor diagnosed on cytology ‐ A rare case report

Paruvathavarthini

Stephen

et al. 2020

Diagnostic Cytopathology

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“…Cutaneous metastasis from visceral cancers regardless of the histotype or the organ of primary malignancy usually represents a diffuse metastatic disease with a dismal prognosis [6] . Early detection of metastasis to the skin is essential to initiate appropriate treatment and recent advances in chemotherapeutic regimes have shown increased survival [7] .…”

Section: Discussionmentioning

confidence: 99%

“…The common sites of cutaneous/subcutaneous metastases are the scalp, abdomen, and chest, followed by the back and extremities [6] . In metastases from an unknown primary, the abdominal wall is the most preferred site [2] .…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Metastasis: A Study of 138 Cases Diagnosed by Fine-Needle Aspiration Cytology

Handa¹,

Kundu²,

Dimri

2016

Acta Cytologica

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Background: Cutaneous metastases can occur in a wide variety of internal malignancies and may be the first sign of a clinically silent visceral cancer. Study Design: A retrospective analysis was made of 138 cases diagnosed with cutaneous and subcutaneous metastasis on fine-needle aspiration cytology (FNAC). Primary tumors of the skin/subcutis were excluded. Results: Of 138 cases, the primary was known in 101 cases and unknown in 37 cases. The age of the patients ranged from 5 to 86 years, and 76 (55.1%) were male and 62 (44.9%) were female. Clinically, the most common lesion was a single nodule (n = 77, 55.8%). The chest wall was the predominant site (n = 53, 38.4%). In males and females, the most common primary sites were the lung (n = 16) and breast (n = 24), respectively. On cytology, the most common diagnosis was metastatic adenocarcinoma (n = 41, 29.7%). Of 37 cases with an unknown primary, FNAC helped to locate the primary site in 17 (45.9%) cases, while in 20 cases it remained undiagnosed. Conclusions: FNAC is a rapid and safe technique that can be used as a first line of investigation for confirmation of metastatic lesions of the skin. Critical evaluation of cytomorphological features along with relevant clinical details could help in the localization of an unknown primary site in some cases.

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Eribulin in Cutaneous Breast Cancer Metastasis Treatment: Clinical Activity and Symptom Control

et al. 2013

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Skin as a site of metastasis

Cited by 5 publications

References 16 publications

Cutaneous metastasis in a case of Wilm's tumor diagnosed on cytology ‐ A rare case report

Cutaneous metastasis in a case of Wilm's tumor diagnosed on cytology ‐ A rare case report

Cutaneous Metastasis: A Study of 138 Cases Diagnosed by Fine-Needle Aspiration Cytology

Eribulin in Cutaneous Breast Cancer Metastasis Treatment: Clinical Activity and Symptom Control

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