Skin Anti-Aging Efficacy of a Four-Botanical Blend Dietary Ingredient: A Randomized, Double Blind, Clinical Study

Abstract

Plant polyphenols have been found to be effective in preventing or reducing different skin alterations. A dietary approach based on these compounds could be a safe and effective method to slow down or prevent age-associated deterioration of skin appearance and function. In a previous study, a specific combination of four botanical extracts (pomegranate, sweet orange, herba Cistanche, and Centella asiatica) exhibited potential anti-aging effects in a dermal fibroblast cell model. The present study aims to clinically evaluate the safety and anti-aging efficacy of this new botanical ingredient (eternalyoung®). To this end, a 12-week randomized, double-blind, placebo-controlled study was carried out in 60 Caucasian women with evident signs of both chrono- and photoaging. Product efficacy was measured as follows: skin moisturization (corneometer), transepidermal water loss (tewameter), skin radiance, and color (spectrophotometer), skin elasticity and firmness (cutometer), skin roughness (image analysis), and skin thickness (ultrasound). Both intergroup and intragroup analysis proved that the daily intake of 225 mg of the active ingredient was enough to produce visible and structural improvements to the skin and to the signs of aging without any side effects. Statistically significant improvements compared to the placebo group were observed as early as 4 weeks regarding wrinkle depth, elasticity, firmness, skin thickness, skin moisturization, transepidermal water loss, and dark spots pigmentation. In addition, the subjects who consumed the blend reported better scores on the self-assessment questionnaires. Our results suggest that the intake of the test product can positively affect the appearance, barrier function, and skin density of aged skin after 12 weeks of treatment.

Skin Anti-Aging Efficacy of a Lactobacillus plantarum GT-17F Fermented Dendrobium officinale Ingredient: A Randomized, Double-Blind, Placebo-Controlled Clinical Study

“…Crucially, FDO outperformed its unfermented counterpart in enhancing skin elasticity and reducing wrinkles and other metrics. In addition to the detection of skin indicators by instruments and equipment, we also refer to the methods of other randomized, double-blind studies and collect questionnaires from the subjects in order to verify the subjective effects of the products [43,44], which further verified the excellent anti-aging effect of FDO. In essence, this study not only illuminates the potential of D. officinale and its fermented version for anti-aging skin care products but also lays the foundation for more in-depth and inclusive research in the future.…”

Valorization of Citrus peels: GC/MS‐based metabolites profiling, multivariate analysis, and antiaging potential

“…[ 24 ] The antioxidant properties of the phenolic compounds may help improve the skin barrier function. [ 25 ] Citrus essential oils are potentially anticipated to be employed in numerous pharmaceutical preparation such as skin‐whitening ingredients in confectioneries, soap and so on, perfumery, and cosmetology with citrus‐like scents. [ 26 ] Hydro‐distillation is the conventional utilized method applied for the investigation of its volatile constituents.…”

Artichoke Leaf Extract Effectiveness on the Skin Aging Exposome: Efficacy and Safety Results of a Split-Face Study

“…Among them, solar radiation and air pollution are exposomal factors that dramatically accelerate skin aging [3,26] by inducing oxidative stress and inflammaging [27][28][29]. As the average human life expectancy is increasing, supporting the skin during the aging process has become a growing concern [30]. This new concept called well-aging involves both lifestyle and the beauty routine and aims to support the natural beauty of the skin at all ages.…”