Skin and Subcutaneous Tissues

Raskin, Rose E.

doi:10.1016/b978-141604985-2.50008-6

Cited by 22 publications

(21 citation statements)

References 64 publications

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“…Before starting the study, the reliability of DQ stained smears in detecting MCs was investigated because the identification of MC granules with DQ may be poor 23 . Indeed, it is well known that metachromatic stains, such as MGG and Wright stains, as well as toluidine blue, are ideal for detecting MCs in cytological preparations, whereas nonmetachromatic dyes, such as DQ, may not stain MC granules 24 . On MGG‐stained preparations, MCs are recognized based on their morphology and presence of dark purple metachromatic granules.…”

Section: Methodsmentioning

confidence: 99%

Morphometrical approach for predicting regional lymph node micrometastatic load in canine mast cell tumours: preliminary results

Marconato

Marchetti

Francione

et al. 2008

Vet Comparative Oncology

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Canine cutaneous mast cell tumours (MCTs) have a variable biologic behaviour, and accurate staging is necessary to dictate therapy and predict outcome. Regional lymph node (RLN) involvement is a relevant prognostic factor. While obvious lymph node (LN) metastases are relatively easy to be diagnosed, micrometastatic disease recognition is challenging. The main aim of the study was to evaluate the number of mast cells (MCs) in the LNs of clinically healthy dogs (n = 4, group 1), dogs with inflammatory diseases (n = 31, group 2) and dogs with cutaneous MCT (n = 27, group 3), including animals with no RLN metastases (subgroup 3.1), those with occasional MCs in RLNs (3.2) and those with obvious RLN metastasis (3.3). MCs also were morphometrically evaluated for the following nuclear parameters: mean nuclear area (MNA), mean nuclear perimeter (MNP), largest to smallest diameter length (LS ratio), mean nuclear form factor and coefficient of variation of nuclear area. The average percentages of MCs were 0.0 and 0.01 in groups 1 and 2, respectively, and 0.07, 2.4 and 47.1 in subgroup 3.1, 3.2 and 3.3. MNA and MNP were significantly higher in subgroup 3.3 than in group 2 (P < 0.05). MNA and MNP in subgroup 3.2 suggested the presence of neoplastic MCs; this prediction of micrometastatic load correlated with outcome. Analysis of preliminary results shows that nuclear morphometry is useful to detect micrometastatic disease in RLN of dogs bearing cutaneous MCTs.

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Section: Methodsmentioning

confidence: 99%

Morphometrical approach for predicting regional lymph node micrometastatic load in canine mast cell tumours: preliminary results

Marconato

Marchetti

Francione

et al. 2008

Vet Comparative Oncology

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“…In dogs, CP is a typically benign tumor found in pinnae, lips, chin, and intraorally between the ages of 4 and 13 years (average 10 years) . Amyloid deposition has been sporadically reported and is often associated with a granulomatous inflammatory reaction and secondary ulceration, as in this case.…”

Section: Discussionmentioning

confidence: 73%

What is your diagnosis? Cutaneous ulcerated nodule in a geriatric dog

Santos

Canadas

Puente-Payo

et al. 2017

Veterinary Clinical Pathol

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“…Nonencapsulated forms can also be found. Organisms range from 4−15 to 8–40 μm, including the capsule, vary from round to fusiform, and contain basophilic internal cell bodies 1 . Narrow‐based budding is a hallmark of this organism.…”

Section: Discussionmentioning

confidence: 99%

“…Narrow‐based budding is a hallmark of this organism. Inflammation may or may not be present owing to the yeast's thick protective capsule 1 …”

Section: Discussionmentioning

confidence: 99%

What is your diagnosis? Urine sediment from a southern California cat with weight loss

Brandt

Blauvelt²

2010

Veterinary Clinical Pathol

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Skin and Subcutaneous Tissues

Cited by 22 publications

References 64 publications

Morphometrical approach for predicting regional lymph node micrometastatic load in canine mast cell tumours: preliminary results

Morphometrical approach for predicting regional lymph node micrometastatic load in canine mast cell tumours: preliminary results

What is your diagnosis? Cutaneous ulcerated nodule in a geriatric dog

What is your diagnosis? Urine sediment from a southern California cat with weight loss

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