Skin and soft tissue infection: microbiology and epidemiology

Dryden, Matthew

doi:10.1016/s0924-8579(09)70541-2

Cited by 150 publications

(144 citation statements)

References 31 publications

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“…Staphylococcus aureus is one of the most prevalent human pathogens, causing a broad variety of diseases ranging from mild skin and soft-tissue infections to infective endocarditis, osteomyelitis, bacteraemia and necrotizing pneumonia (Al-Talib et al, 2011;Dryden, 2009;Yamada et al, 2011). Since the first report of a drug-resistant S. aureus strain in 1961, these resilient bacteria have become a particular threat to human health.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010

Yan

et al. 2013

Journal of Medical Microbiology

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Staphylococcus aureus, including meticillin-sensitive and -resistant S. aureus (MSSA and MRSA, respectively), is associated with severe nosocomial human infections. This study aimed to investigate the molecular profile, including the dynamic changes and genotype/phenotype correlation, of S. aureus isolates recovered from different clinical specimens of inpatients with S. aureus infection over a 6-year span at a teaching hospital in Shanghai, China. Between 2005 and 2010, a random sample of 610 unique S. aureus isolates was collected from different clinical samples of inpatients with S. aureus infection for molecular and antibiotic susceptibility analysis. The results showed that, among the 610 S. aureus isolates, 20 sequence types (STs) determined by multi-locus sequence typing (primarily ST239, ST5, ST7, ST188 and ST398) and 52 spa types (primarily t002, t037, t030 and t601) were found. In total, 444 isolates (72.8 %) were MRSA and 166 (27.2 %) were MSSA. ST239-MRSA-III-spa t037 and ST5-MRSA-II-spa t002 were the predominant MRSA clones. From 2005 to 2010, spa t002, spa t037 and their corresponding STs (ST5 and ST239) were the most frequent clones among all of the S. aureus isolates and showed the most resistant phenotypes to various antibiotics. Generally, the different genotypes showed different drug resistance rates, but no isolates were resistant to vancomycin, teicoplanin or linezolid. The profiles of virulence and resistance genes differed by genetic background, with the ST239 and ST5 strains showing higher resistance rates to gentamicin, cefoxitin, ampicillin, cefazolin, erythromycin, clindamycin and levofloxacin than strains of other types. Moreover, the antiseptic resistance genes qacA/B were generally associated with these two types. The prevalence of STs was different among different clinical specimens and also changed by year. Recently (2009Recently ( -2010, the distribution of predominant MRSA clones decreased, whilst the prevalence of non-predominant MSSA clones increased, especially for the isolates causing bacteraemia. Continual monitoring of clinical isolates is necessary to develop and maintain an effective strategy against S. aureus infection in the hospital setting.

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Section: Introductionmentioning

confidence: 99%

Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010

Yan

et al. 2013

Journal of Medical Microbiology

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“…The few published multi-centre studies characterising SSTI pathogens have been limited to specific types of organisms [30], with almost all reports on SSTIs in diabetic patients limited to foot infections [31][32][33]. Few studies have addressed the interaction of specific pathogens with various clinical and economic outcomes [34].…”

Section: Introductionmentioning

confidence: 99%

Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost

Tabak²,

et al. 2010

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Aims/hypothesis Skin and soft tissue infections (SSTIs) cause substantial morbidity in persons with diabetes. There are few data on pathogens or risk factors associated with important outcomes in diabetic patients hospitalised with SSTIs. Methods Using a clinical research database from CareFusion, we identified 3,030 hospitalised diabetic patients with positive culture isolates and a diagnosis of SSTI in 97 US hospitals between 2003 and 2007. We classified the culture isolates and analysed their association with the anatomic location of infection, mortality, length of stay and hospital costs. Results The only culture isolate with a significantly increased prevalence was methicillin-resistant Staphylococcus aureus (MRSA); prevalence for infection of the foot was increased from 11.6 to 21.9% (p<0.0001) and for non-foot locations from 14.0% to 24.6% (p=0.006). Patients with non-foot (vs foot) infections were more severely ill at presentation and had higher mortality rates (2.2% vs 1.0%, p<0.05). Significant independent risk factors associated with higher mortality rates included having a polymicrobial culture with Pseudomonas aeruginosa (OR 3

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“…2 the presence of bacteria over the skin surface or even on an ulcer doesn't mean that this microbe is responsible for the pathology. Unless there are signs of inflammation over the skin surface, result of wound swab culture should be viewed with suspicion and all efforts should be undertaken to differentiate pathogen from a colonizer before hunting for the sensitivity pattern and commencing on a lengthy antibiotic regimen.…”

Section: Introductionmentioning

confidence: 99%

Skin and Soft Tissue Infections

Ekenna¹

2016

Cases in Clinical Infectious Disease Practice: Obtaining a Good History From the Patient Remains the Cornerstone of an Accurate

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Skin and soft tissue infection: microbiology and epidemiology

Cited by 150 publications

References 31 publications

Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010

Phenotypic and molecular characterization of Staphylococcus aureus recovered from different clinical specimens of inpatients at a teaching hospital in Shanghai between 2005 and 2010

Skin and soft tissue infections in hospitalised patients with diabetes: culture isolates and risk factors associated with mortality, length of stay and cost

Skin and Soft Tissue Infections

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