Skin ageing and oxidative stress in a narrow-age cohort of older adults

Allerhand, Michael; Ooi, E.; Starr, Robert J.; Alcorn, Michael; Penke, Lars; Drost, Ellen; MacNee, William; Deary, Ian J.; Starr, John M.

doi:10.1016/j.eurger.2011.04.009

Cited by 19 publications

(25 citation statements)

References 19 publications

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“…That is reasonable and in line with a previous study [34]. We observed higher skin ageing, wrinkle, and sagging scores in the aged groups, which supports the construct validity of the applied clinical scales [26–28]. We also reproduced an age-dependent increase in R max⁡ und R z [35, 36].…”

Section: Discussionsupporting

confidence: 93%

Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena

Trojahn

Dobos

Lichterfeld

et al. 2015

BioMed Research International

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Facial skin ageing is caused by intrinsic and extrinsic mechanisms. Intrinsic ageing is highly related to chronological age. Age related skin changes can be measured using clinical and biophysical methods. The aim of this study was to evaluate whether and how clinical characteristics and biophysical parameters are associated with each other with and without adjustment for chronological age. Twenty-four female subjects of three age groups were enrolled. Clinical assessments (global facial skin ageing, wrinkling, and sagging), and biophysical measurements (roughness, colour, skin elasticity, and barrier function) were conducted at both upper cheeks. Pearson's correlations and linear regression models adjusted for age were calculated. Most of the measured parameters were correlated with chronological age (e.g., association with wrinkle score, r = 0.901) and with each other (e.g., residual skin deformation and wrinkle score, r = 0.606). After statistical adjustment for age, only few associations remained (e.g., mean roughness (R z) and luminance (L *), β = −0.507, R 2 = 0.377). Chronological age as surrogate marker for intrinsic ageing has the most important influence on most facial skin ageing signs. Changes in skin elasticity, wrinkling, sagging, and yellowness seem to be caused by additional extrinsic ageing.

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Section: Discussionsupporting

confidence: 93%

Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena

Trojahn

Dobos

Lichterfeld

et al. 2015

BioMed Research International

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“…In this sample, facial skin aging has been found to be related to oxidative stress, a general health marker (29). One factor associated with both accelerated skin aging (30) and mortality (31,32) is smoking.…”

Section: Potential Mechanisms Linking Rated Age With Mortalitymentioning

confidence: 98%

Predicting Mortality From Human Faces

Dykiert

Bates

Gow

et al. 2012

Psychosomatic Medicine

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“…14 Studies have shown that ultraviolet radiation 16 and infrared radiation 17 reduce the concentration of carotenoids in the skin, presumably because the carotenoids are destroyed through their interaction with radiation-induced free radicals. Oxidative stress is associated with enhanced skin aging, 18 and conversely, skin with a high carotenoid concentration appears younger 14 and has fewer furrows and wrinkles than skin with a low carotenoid concentration. 19 Supplementation with beta-carotene (and increased dietary intake of fruit and vegetables) also produces an increase in the normal skin yellowness 20-22 -but not skin redness or luminance 21 -of Caucasian skin, and studies have shown that a somewhat yellower skin color is considered healthier and more attractive by both African and Caucasian observers.…”

Section: Introductionmentioning

confidence: 99%

Effect of beta-carotene supplementation on African skin

Coetzee

Perrett

2014

J. Biomed. Opt

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Abstract. The quantification of skin carotenoid levels has a range of applications in Caucasian populations, from serving as a versatile and noninvasive biomarker (e.g., of systemic carotenoid levels, carotenoid consumption, the antioxidative capacity of skin, and oxidative stress) to being used in appearance-based interventions. Yet, no study has investigated the quantitative effect of carotenoid supplementation on African skin. The aim of this study was to determine if beta-carotene supplementation produces a significant color change in three different regions of African skin. To do so we supplemented the diet of African participants with beta-carotene over an eight-week period. Reflectance spectrophotometry measurements were taken on a weekly basis for the duration of the supplementation study. Results show a significant increase in the carotenoid coloration of lightly pigmented skin (palm of the hand) and highly pigmented skin with low sun exposure (inner arm) after supplementation. The latter was no longer significant after Bonferroni correction. The carotenoid coloration of highly pigmented skin areas with high sun exposure did not increase significantly. Skin carotenoid measurements of the palm of the hand might, therefore, serve as a potential biomarker for systemic carotenoid concentrations in people of African descent.

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Skin ageing and oxidative stress in a narrow-age cohort of older adults

Cited by 19 publications

References 19 publications

Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena

Characterizing Facial Skin Ageing in Humans: Disentangling Extrinsic from Intrinsic Biological Phenomena

Predicting Mortality From Human Faces

Effect of beta-carotene supplementation on African skin

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