Skin adnexal neoplasms—part 1: An approach to tumours of the pilosebaceous unit

Alsaad, Khaled O.; Obaidat, Nidal A.; Ghazarian, Danny

doi:10.1136/jcp.2006.040337

Cited by 176 publications

(245 citation statements)

References 78 publications

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“…15 Sebaceous hyperplasia may be seen in MTS, but does not fulfill diagnostic criteria. 31 Sebaceous hyperplasia consists of a single enlarged sebaceous gland with 5 or more lobules of bland, immature sebocytes that open into a single dilated follicular infundibulum.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…In cutaneous tumors, sebaceous differentiation manifests as cells with coarsely vacuolated cytoplasm and starry nuclei (so-called mulberry cells). 15 Sebaceous cells are immunoreactive for epithelial membrane antigen.…”

Section: Pathologic Featuresmentioning

confidence: 99%

“…15 Sebaceous adenomas lack a central draining duct (in contrast to the more commonly encountered sebaceous hyperplasia). Muir-Torre syndrome-associated tumors are often nodulocystic and commonly occur on the trunk and extremities.…”

Section: Pathologic Featuresmentioning

confidence: 99%

“…16 Unlike benign sebaceous neoplasms, sebaceous carcinoma shows features of malignancy: it is asymmetrical with poor circumscription, and has an infiltrative growth pattern, a preponderance of pleomorphic basaloid cells arranged in solid sheets, marked cytologic atypia, high mitotic activity, and variable tumor necrosis (Figure 3). 15 The basaloid tumor mass may contain scattered sebocytes. Unlike in BCC, peripheral palisading and artefactual clefting are notably absent.…”

Section: Pathologic Featuresmentioning

confidence: 99%

“…17 Histologic variants of sebaceous carcinoma include the basaloid, spindle cell, squamoid, and dedifferentiated (pleomorphic) variants. 15 Basaloid sebaceous carcinoma consists of small basaloid cells in lobules with peripheral palisading and inconspicuous sebocytes. The spindle cell variant is composed predominantly of spindle cells with foci of squamous metaplasia.…”

Section: Pathologic Featuresmentioning

confidence: 99%

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Muir-Torre Syndrome

Bhaijee

Brown

2014

Archives of Pathology &Amp; Laboratory Medicine

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Muir-Torre syndrome (MTS) is a rare autosomal-dominant genodermatosis characterized by sebaceous neoplasms and one or more visceral malignancies. Sebaceous tumors include sebaceous adenoma and carcinoma, which may be solitary or multiple. Visceral malignancies most often arise in the colorectum and endometrium. Because a subset of patients with phenotypic MTS will have germline mutations in the DNA mismatch repair genes hMSH2 and hMLH1, MTS is considered a phenotypic subtype of Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer syndrome), in which inherited defects in DNA mismatch repair genes result in microsatellite instability. Pathologists have an important role in the early detection and initial diagnosis of MTS: identification of at-risk individuals allows appropriate screening and surveillance for visceral malignancies, thereby reducing morbidity and mortality. Herein, we describe the clinicopathologic features of MTS.

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Section: Differential Diagnosismentioning

confidence: 99%

Section: Pathologic Featuresmentioning

confidence: 99%

Section: Pathologic Featuresmentioning

confidence: 99%

Section: Pathologic Featuresmentioning

confidence: 99%

Section: Pathologic Featuresmentioning

confidence: 99%

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Muir-Torre Syndrome

Bhaijee

Brown

2014

Archives of Pathology &Amp; Laboratory Medicine

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Fine‐needle aspiration cytology in the diagnosis of malignant proliferating trichilemmal tumor: Report of a case and review of the literature

Kini

2009

Diagnostic Cytopathology

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Malignant proliferating trichilemmal tumor is a rare cutaneous neoplasm derived from the outer root sheath of the hair follicle. Fine-needle aspiration cytology is being increasingly used in the investigation of primary and metastatic cutaneous tumors. However, there are few reports on the cytology of trichilemmal tumors in the literature. We describe the cytological features of this uncommon adnexal tumor presenting as a scalp mass in a 58-year-old woman. In view of its aggressive biological behavior, it is crucial for cytologists to be aware of this rare lesion and distinguish it from primary cutaneous squamous-cell carcinoma. The differences on fine-needle aspiration cytology can be subtle and pose problems in diagnosis.

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Fine‐needle aspiration of scalp masses: A review of 30 cases

Doan

Ramani

Arbab

et al. 2022

Diagnostic Cytopathology

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Introduction: Scalp masses are often the initial presentation of a widely disseminated malignancy. Fine-needle aspiration (FNA) is an optimal method for obtaining an accurate tissue diagnosis, in these patients with initial presentation and those with a known malignancy. Materials and Methods:We reviewed all FNAs of skin and soft tissue lesions from the scalp at our institution over a period of 31 years . Relevant clinical information was obtained from the review of computerized patient record. The histologic type, presentation, previous diagnoses, and survival after the diagnosis were correlated.Results: Thirty patients with scalp masses were identified. All the patients were males with a median age of 61 years (27-81 years). The scalp masses ranged from 0.4 to 6 cm in size. Ten cases (33%) were benign, but the majority of cases (n = 20, 67%) were malignant. Of the malignant lesions sampled, 1 case was a primary squamouscell carcinoma (SCC), and the remaining 19 cases were metastatic tumors. Of these, 13 cases (68.4%) had a previously diagnosed malignancy. Most of the 19 metastatic lesions were adenocarcinomas or poorly differentiated carcinomas (n = 12, 63.2%), followed by melanoma (n = 4), SCC (n = 1), alveolar soft part sarcoma (n = 1) and large cell lymphoma (n = 1). The most common site of primary was the gastrointestinal tract (6/19, 31.5%) and lung (6/19, 31.5%). The average survival after the diagnosis of these scalp metastases was around 6.3 months, signifying a poor prognosis. Conclusion:In our patient population, most scalp masses were metastatic tumors. Metastasis to the scalp signals advanced disease and is associated with a very poor prognosis. FNA is an easy, safe, rapid, cost effective and precise modality for diagnosing these masses. It can also yield material for molecular testing for newer directed therapies, if needed.

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Skin adnexal neoplasms—part 1: An approach to tumours of the pilosebaceous unit

Cited by 176 publications

References 78 publications

Muir-Torre Syndrome

Muir-Torre Syndrome

Fine‐needle aspiration cytology in the diagnosis of malignant proliferating trichilemmal tumor: Report of a case and review of the literature

Fine‐needle aspiration of scalp masses: A review of 30 cases

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