Ski Acts as Therapeutic Target of Qingyihuaji Formula in the Treatment of SW1990 Pancreatic Cancer

Wang, Peng; Chen, Zhen; Meng, Zhi Qiang; Luo, Jian; Lin, Jun; Zhou, Zhen; Chen, Hao; Wang, Kun; Ye, Shen; Liu, Lu Ming

doi:10.1177/1534735409359179

Cited by 14 publications

(13 citation statements)

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“…A recent study suggested that EGCG lowers the concentration of curcumin needed to reduce proliferation and induce apoptosis in uterine leiomyosarcoma cells [252]. Traditional Chinese medicine formulas have also been subjected to extensive pharmacological testing [253,254]. However, much remains to be done in quantitative optimization of formulas as well as in selection of optimal natural product extracts or phytochemicals.…”

Section: Discussionmentioning

confidence: 99%

Designing a broad-spectrum integrative approach for cancer prevention and treatment

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Gyllenhaal

Lowe

et al. 2015

Seminars in Cancer Biology

233

188

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Targeted therapies and the consequent adoption of “personalized” oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity “broad-spectrum” therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested; many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment. Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to help us address disease relapse, which is a substantial and longstanding problem, so a proposed agenda for future research is offered.

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Section: Discussionmentioning

confidence: 99%

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Block

Gyllenhaal

Lowe

et al. 2015

Seminars in Cancer Biology

233

188

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“…Application of integrative TCM and Western medicine to treat pancreatic cancer has shown promising results. Our previous studies have shown that TCM could inhibit the tumor growth in vivo and in vitro by interfering in many mechanisms [28, 29]. As the rare resources of Taxol which is approved for the treatment of kinds of tumors, the conventional application of Taxus cuspidate, different from the Western medicines, is also used in cancer patients' treatment.…”

Section: Discussionmentioning

confidence: 99%

Antitumor Effect of Water Decoctions ofTaxusCuspidate on Pancreatic Cancer

Chen

2014

Evidence-Based Complementary and Alternative Medicine

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The Taxus cuspidate has been used as a traditional Chinese medicinal herb and considered to affect various physiological functions in the body for thousands of years. As we know that taxol isolated from the Taxus cuspidate has been approved for the treatment of ovarian cancer, it has also shown its antitumor abilities against other kinds of cancers. But the antitumor activity of other components which are free of paclitaxel and hydrophilic paclitaxel derivatives from Taxus cuspidate has not been fully understood. In this study, we investigated the effect of the water decoctions from the leaves of Taxus cuspidate on pancreatic cancer cell proliferation and the potential mechanism(s); though its antitumor activity and mechanism in vitro remain to be elucidated, the water soluble constituents from Taxus cuspidate could be used in clinical for cancer patients.

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“…The daily dosage for nude mice was 36 g/kg, once per day p.o., respectively, calculated according to the following human-mouse transfer formula: D b = D a × ( R b / R a )×( W b / W a )2/3, where D , R , and W represent dosage, shape coefficient, and body weight, respectively, and a and b represent human and mouse, respectively. Gemcitabine (Eli Lilly) was dissolved in sterile PBS, 25 mg/kg [14, 15], twice per week by intraperitoneal injection. Antibodies of rabbit anti-human Nanog were purchased from Abcam.…”

Section: Methodsmentioning

confidence: 99%

Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells

Gao

Pan

Song

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Qingyihuaji formula (QYHJ), confirmed efficacious in a series of clinical trials, has been applied to human pancreatic carcinoma treatment in Shanghai Cancer Center for years. Recent evidence highlighted that pluripotent stem cells transcription factor Nanog plays a pivotal role in carcinogenesis. However, there is little published information regarding the underlying clinical significance and mechanisms of transcription factor Nanog in pancreatic cancer. In this study, our results indicated that Nanog is overexpressed in human pancreatic cancer stem cells and downregulated by QYHJ, which may contribute to explain the clinical effectiveness of QYHJ and provide advanced pancreatic cancer patients with a new therapeutic option, supporting our hypothesis that the degradation pathway is another mechanism by which QYHJ affects Nanog expression.

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Ski Acts as Therapeutic Target of Qingyihuaji Formula in the Treatment of SW1990 Pancreatic Cancer

Cited by 14 publications

References 13 publications

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Antitumor Effect of Water Decoctions ofTaxusCuspidate on Pancreatic Cancer

Nanog Predicts Poor Prognosis in Human Pancreatic Cancer and Is Downregulated by QingyihuaJi Formula in Pancreatic Cancer Stem Cells

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