Abstract:During early human development, females randomly inactivate one of the two X chromosomes in a process called X chromosome inactivation. Since this process is usually random, most women are a balanced 50:50 mosaic of cells. While this is the situation in young females, mosaicism is usually lost in the elderly, particularly in the blood, a process referred to as skewing. We have previously shown, using primary cell populations, that skewing is highly predictable in vitro and results from hemizygous selection whe… Show more
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