Skene's Gland Adenocarcinoma Resembling Prostatic Adenocarcinoma

Pongtippan, Atcharaporn; Malpica, Anaís; Levenback, Charles; Deavers, Michael T.; Silva, Elvio G.

doi:10.1097/01.pgp.0000101144.79462.39

Cited by 59 publications

(29 citation statements)

References 28 publications

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“…Ectopic prostatic tissues in the uterine cervix and vagina, including benign and malignant patterns, has been recorded. 4,5,8,9 Adenocarcinomas of paraurethral Skene glands have been noted to display distinct similarities to analogous lesions in the male prostate. 15 However, Skene gland hyperplasia, the equivalent of the most common lesion in the male prostate, is very unusual.…”

Section: Discussionmentioning

confidence: 97%

“…However, there are reported examples in the uterine cervix and vagina. 4,5,8,9,15 McCluggage and Young reported glands with positivity for both prostate-specific antigen (PSA) and prostatic acid phosphatase (PrAP) in a distinct vaginal lesion, the tubulosquamous polyp. 7 In this article, we present morphologically and histogenetically variable lesions occurring in the lower female genital tract with features of prostatic differentiation.…”

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confidence: 98%

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Prostatic-type Tissue in the Lower Female Genital Tract: A Morphologic Spectrum, Including Vaginal Tubulosquamous Polyp, Adenomyomatous Hyperplasia of Paraurethral Skene Glands (Female Prostate), and Ectopic Lesion in the Vulva

Kazakov¹,

Stewart

Kacerovská³

et al. 2010

American Journal of Surgical Pathology

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The investigators report a series of prostatic-type lesions occurring in the lower female genital tract. The cases included a 4.5-cm mass representing hyperplasia of the glandular and stromal tissue of paraurethral Skene gland, a small ectopic prostatic lesion in the vulva, and 4 tubulosquamous vaginal polyps. All lesions were immunopositive for prostate-specific antigen and/or prostatic acid phosphatase. A brief discussion of the earlier published material is included.

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 98%

Prostatic-type Tissue in the Lower Female Genital Tract: A Morphologic Spectrum, Including Vaginal Tubulosquamous Polyp, Adenomyomatous Hyperplasia of Paraurethral Skene Glands (Female Prostate), and Ectopic Lesion in the Vulva

Kazakov¹,

Stewart

Kacerovská³

et al. 2010

American Journal of Surgical Pathology

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“…Occasional adenocarcinomas and adenoid cystic carcinomas derived from periurethral Skene's glands have also been reported (13,14). Primary urethral carcinomas are rare and most are transitional in type.…”

Section: Serous Carcinoma Of the Urethra Or Urethral Diverticulummentioning

confidence: 95%

Primary High-grade Serous Carcinoma Arising in the Urethra or Urethral Diverticulum

Flynn

Oxley²,

McCullagh³

et al. 2013

International Journal of Gynecological Pathology

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Serous carcinomas most commonly arise within the uterine corpus or ovary/fallopian tube, but there are 2 prior case reports of primary vaginal serous carcinoma. We report 2 examples of high-grade serous carcinoma arising within the urethra or a urethral diverticulum (1 case each). Both neoplasms exhibited the classic morphologic features of high-grade serous carcinoma, and a combination of clinical, radiologic, and pathologic examination excluded other possible sites of primary neoplasm.

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“…However, occasional prostatic adenocarcinomas, termed Skene's gland adenocarcinomas, have been reported 611 MISPLACED SKENE'S GLANDS in the vagina (24)(25)(26); these have been positive with prostatic markers and are believed to derive from Skene's glands. However, occasional prostatic adenocarcinomas, termed Skene's gland adenocarcinomas, have been reported 611 MISPLACED SKENE'S GLANDS in the vagina (24)(25)(26); these have been positive with prostatic markers and are believed to derive from Skene's glands.…”

Section: Misplaced Skene's Glandsmentioning

confidence: 99%

Misplaced Skeneʼs Glands

Kelly

McBride

Kennedy

et al. 2011

International Journal of Gynecological Pathology

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So-called ectopic prostatic tissue in the cervix and vaginal tubulosquamous polyps are rare morphologically similar lesions that may show positive immunohistochemical staining with prostatic markers. It has been suggested that they are related to paraurethral Skene's glands that are the female equivalent of prostatic glands in the male. We report a large series of lesions in women aged 23 to 81 years, found within the cervix (n=24), vagina (n=10), and vulva (n=2), which we believe to be a part of a spectrum of lesions derived from Skene's glands, either eutopic or more commonly misplaced during embryonic development. In all cervical cases, the lesion was predominantly situated in the ectocervix and was an incidental finding in specimens procured for a variety of reasons. In the vagina, the lesions usually presented themselves as polyps or cysts, although occasionally they were an incidental finding. The 2 vulval cases were incidental findings in punch biopsies. The basic morphological features were of epithelial elements of both glandular and squamous type; in some cases, the glandular elements formed a double cell layer. Uncommon findings included the presence of sebaceous glands in 2 cases (1 cervix, 1 vagina), basaloid formations resembling hair follicle structures in 4 (2 cervix, 2 vagina), and a microglandular proliferation resembling nephrogenic adenoma in 1 vaginal case. Prostate-specific antigen was positive in 13 of 26 cases and prostatic acid phosphatase in 16 of 26 tested. Six cases were negative with both markers. We propose that these benign lesions in the cervix, vagina, and vulva are derived from eutopic or misplaced Skene's glands.

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Skene's Gland Adenocarcinoma Resembling Prostatic Adenocarcinoma

Cited by 59 publications

References 28 publications

Prostatic-type Tissue in the Lower Female Genital Tract: A Morphologic Spectrum, Including Vaginal Tubulosquamous Polyp, Adenomyomatous Hyperplasia of Paraurethral Skene Glands (Female Prostate), and Ectopic Lesion in the Vulva

Prostatic-type Tissue in the Lower Female Genital Tract: A Morphologic Spectrum, Including Vaginal Tubulosquamous Polyp, Adenomyomatous Hyperplasia of Paraurethral Skene Glands (Female Prostate), and Ectopic Lesion in the Vulva

Primary High-grade Serous Carcinoma Arising in the Urethra or Urethral Diverticulum

Misplaced Skeneʼs Glands

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