Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence

Golding, Jon P.; Calderbank, Emma; Partridge, Terence A.; Beauchamp, Jonathan R.

doi:10.1016/j.yexcr.2006.10.019

Cited by 59 publications

(41 citation statements)

References 70 publications

(5 reference statements)

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“…This possibility is supported by the phenotypes observed in embryos overexpressing the inhibitor of apoptosis, DIAP1, as well as in mutants of different inducers of apoptosis. Of interest, a similar anti-apoptotic effect of the EGF pathway on activated satellite cells has been recently reported (Golding et al, 2007). These results provide additional evidence that Drosophila AMPs behave like vertebrate satellite cells and indicate that gaining insight into the genetic control of AMPs specification, proliferation, and survival may help in our understanding of muscle stem cell biology in general.…”

Section: Drosophila An Emerging Model To Study Muscle Stem Cellssupporting

confidence: 71%

Muscle stem cells and model systems for their investigation

Figeac

Daczewska

Marcelle

et al. 2007

Developmental Dynamics

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Section: Drosophila An Emerging Model To Study Muscle Stem Cellssupporting

confidence: 71%

Muscle stem cells and model systems for their investigation

Figeac

Daczewska

Marcelle

et al. 2007

Developmental Dynamics

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“…6). It also turns out that the anti-apoptotic role of the EGFR pathway in Drosophila AMPs described here is conserved across evolution, as EGF signalling also promotes survival of vertebrate satellite cells (Golding et al, 2007).…”

Section: Egf Signalling Is Required For Specification and Maintenancementioning

confidence: 71%

Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway

et al. 2010

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SUMMARYIn Drosophila, a population of muscle-committed stem-like cells called adult muscle precursors (AMPs) keeps an undifferentiated and quiescent state during embryonic life. The embryonic AMPs are at the origin of all adult fly muscles and, as we demonstrate here, they express repressors of myogenic differentiation and targets of the Notch pathway known to be involved in muscle cell stemness. By targeting GFP to the AMP cell membranes, we show that AMPs are tightly associated with the peripheral nervous system and with a subset of differentiated muscles. They send long cellular processes running along the peripheral nerves and, by the end of embryogenesis, form a network of interconnected cells. Based on evidence from laser ablation experiments, the main role of these cellular extensions is to maintain correct spatial positioning of AMPs. To gain insights into mechanisms that lead to AMP cell specification, we performed a gain-of-function screen with a special focus on lateral AMPs expressing the homeobox gene ladybird. Our data show that the rhomboid-triggered EGF signalling pathway controls both the specification and the subsequent maintenance of AMP cells. This finding is supported by the identification of EGF-secreting cells in the lateral domain and the EGF-dependent regulatory modules that drive expression of the ladybird gene in lateral AMPs. Taken together, our results reveal an unsuspected capacity of embryonic AMPs to form a cell network, and shed light on the mechanisms governing their specification and maintenance.

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“…Proteoglycans reside on the surface of satellite cells and function as receptors to bind a suite of secreted, yet inactive growth factor precursors. These precursors, including HGF (521), basic fibroblast growth factor (bFGF) (141), epidermal growth factor (EGF) (193), insulin-like growth factor isoforms (IGF-I, IGF-II) (323) and various Wnt glycoproteins (65,293), originate from either satellite cells, myofibers, interstitial cells, or serum. In resting muscle, the sequestering of inactive growth factors exists as a local reservoir, to facilitate a rapid response to muscle injury.…”

Section: Ecm and Associated Factorsmentioning

confidence: 99%

Satellite Cells and the Muscle Stem Cell Niche

Yin

Price

Rudnicki

2013

Physiological Reviews

1,720

1,808

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LYin H, Price F, Rudnicki MA. Satellite Cells and the Muscle Stem Cell Niche. Physiol Rev 93: 23-67, 2013; doi:10.1152/physrev.00043.2011.-Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated process involving the activation of various cellular and molecular responses. As skeletal muscle stem cells, satellite cells play an indispensible role in this process. The self-renewing proliferation of satellite cells not only maintains the stem cell population but also provides numerous myogenic cells, which proliferate, differentiate, fuse, and lead to new myofiber formation and reconstitution of a functional contractile apparatus. The complex behavior of satellite cells during skeletal muscle regeneration is tightly regulated through the dynamic interplay between intrinsic factors within satellite cells and extrinsic factors constituting the muscle stem cell niche/microenvironment. For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved our understanding of skeletal muscle biology. Here, we review some recent advances, with focuses on functions of satellite cells and their niche during the process of skeletal muscle regeneration.

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Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence

Abstract: (2007

Cited by 59 publications

References 70 publications

Muscle stem cells and model systems for their investigation

Muscle stem cells and model systems for their investigation

Drosophila adult muscle precursors form a network of interconnected cells and are specified by the rhomboid-triggered EGF pathway

Satellite Cells and the Muscle Stem Cell Niche

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