Skeletal muscle satellite stem cells at different postmortem intervals

Ceausu, Mihai; Hostiuc, Sorin; Dermengiu, Dan

doi:10.4323/rjlm.2016.23

Cited by 3 publications

(5 citation statements)

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“…Their distribution along the muscular fiber. In agreement with our suggestion Ceausu et al, 2016 found the same results in post mortum examination of skeletal muscles [28].…”

Section: Cd117/c-kitsupporting

confidence: 93%

The Possible Role of Nanocurcumin in Rat Model of Statin Induced Myopathy: Histological and Immune Histochemical Study

Mohamed

Abdelhaleem

Shaaban

et al. 2022

JAMMR

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Background: Statins are the most commonly used drugs for reducing hypercholesterolemia. Unfortunately, statins induced myopathy is a common side effect of statins. Usually represented by fatigue, muscle pain, muscle tenderness, muscle weakness and nocturnal cramping. Curcumin has been proved as anti –inflammatory agent in the inflammatory conditions. Aim: This research aimed to study the protective effect of nanocurcumin on the histological changes produced by atorvastatin in the skeletal muscles. Material and Methods: A thirty albino rats (2-3 months old) were used in the present study. The rats were randomly divided into four groups. Group I: (five rats) and was used as a control group (control) , they were given 2 ml carboxy methyl cellulous (0.5%)orally through orogastric tube daily for 4 weeks. Group II: (five rats) They were given nanocurcumin in a dose of 15ml \kg b.w orally through orogastric tube daily for 4weeks. Group III: (ten rats) They were be given atorvastatin in a dose of 40 ml \kg b.w orally through orogastric tube daily for 4 weeks and divided into two subgroups. Group III a (animal model): scarified 24h after the last dose. Group III b (recovery group): scarified 2weeks after the last dose. Group IV: (ten rats) they were given atorvastatin in a dose of 40 ml \kg b.w orally through orogastric for 4 weeks followed by nanocurcumin in a dose of 15mg \kg b.w orally daily for 4weeks. Results: Degenerative and apoptotic changes were observed in the skeletal muscles in the atorvastatin treated groups, these changes could be attenuated by administration of nanocurcumin. Conclusion: Apoptosis is a mechanism of atorvastatin induced myopathy. Nanocurcumin particles could attenuate this process and attenuated the toxicity of the drug. After stoppage of atorvastatin some of histopathological changes could be recovered.

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“…Their distribution along the muscular fiber. In agreement with our suggestion Ceausu et al, 2016 found the same results in post mortum examination of skeletal muscles [28].…”

Section: Cd117/c-kitsupporting

confidence: 93%

The Possible Role of Nanocurcumin in Rat Model of Statin Induced Myopathy: Histological and Immune Histochemical Study

Mohamed

Abdelhaleem

Shaaban

et al. 2022

JAMMR

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“…The number of cases for each article varied, with a minimum of four cases described by Ceausu et al [ 41 ] and a maximum number of 500 described by Wehner et al [ 38 ]. The cause of death varied, with most cases related to sudden cardiac death, traumatic brain injury, and neoplastic disease.…”

Section: Resultsmentioning

confidence: 99%

“…The samples used to estimate the PMI came from different organs, such as brain [ 38 , 39 , 42 ], thyroid [ 35 , 36 ], pancreas [ 34 , 37 , 38 ], gingival tissue [ 14 , 27 ], skin [ 44 ], heart [ 33 , 43 ], large intestine [ 45 ], female genital system [ 46 ], bone marrow [ 40 ], skeletal muscle [ 41 ], as well as lung and liver [ 42 ]. For these tissues, the various authors used different markers, without any overlap or repetition ( Figure 2 ).…”

Section: Resultsmentioning

confidence: 99%

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New Trends in Immunohistochemical Methods to Estimate the Time since Death: A Review

et al. 2022

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The identification of a reliable and accurate post-mortem interval (PMI) is a major challenge in the field of forensic sciences and criminal investigation. Several laboratory techniques have recently been developed that offer a better contribution to the estimation of PMI, in addition to the traditional physical or physico-chemical (body cooling, lividity, radiocarbon dating, rigor mortis), chemical (autolysis), microbiological (putrefaction), entomological, as well as botanical parameters. Molecular biology (degradation pattern of macromolecules such as proteins, DNA, RNA), biochemical analysis of biological fluids (such as blood, cerebrospinal fluid, and vitreous humor), and immunohistochemistry are some of the most recent technological innovations. A systematic review of the literature was performed with the aim of presenting an up-to-date overview on the correlation between the immunohistochemical (IHC) expression of specific antigenic markers at different PMIs. The systematic review was performed according to PRISMA guidelines. Scopus and PubMed were used as search engines from January 1, 1998 to March 1, 2022 to evaluate the effectiveness of immunohistochemistry in estimating PMI. The following keywords were used: (immunohistochemical) OR (immunohistochemistry) AND (time since death) OR (post-mortem interval) OR (PMI). A total of 6571 articles were collected. Ultimately, 16 studies were included in this review. The results of this systematic review highlighted that IHC techniques, in association with traditional methods, add, in Bayesian terms, additional information to define a more accurate time of death and PMI. However, current IHC results are numerically limited and more data and studies are desirable in the near future.

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“…They follow a migratory path from the base of the crypt toward the villi. In skeletal muscle they were identified up to 17 days in humans and up to 14 days in animal experimental models (mice) post-mortem (14) and they were also demonstrated in human cadavers up to six days after the estimated time of death (15). Stem cells exist not only in skeletal muscle, but also in the myocardium.…”

Section: Discussionmentioning

confidence: 95%

Dormant cardiac stem cells: A promising tool in cardiac regeneration

et al. 2020

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Stem cells represent an old niche with various new potential therapeutics. Besides drug treatment, reperfusion procedures and surgical revascularization, stem cell therapy could be a good option in ischemic cardiac diseases. A study was performed on a small group of cases who died of cardiac arrhythmia secondary to scarring myocardial infarctions. Tissue cardiac samples were taken from these cases (from the anterior and lateral wall of the left ventricle), for microscopy examination, in order to investigate the presence of cardiac stem cells (CSC). Multiple series of histological sections were also performed and examined, along with immunohistochemical analysis (IHC). The cells were identified in close contact with the residual ischemic cardiomyocytes, in the proximity of the myocardial collagenous scar, in old myocardial infarctions. They were activated by hypoxic ischemia and were influenced by the capillary microvascular density and the interstitial micro-environment conditions. In chronic intermittent ischemia they seem to turn themselves from dormant quiescent cells into activated progenitor committed cells.

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Skeletal muscle satellite stem cells at different postmortem intervals

Cited by 3 publications

References 0 publications

The Possible Role of Nanocurcumin in Rat Model of Statin Induced Myopathy: Histological and Immune Histochemical Study

The Possible Role of Nanocurcumin in Rat Model of Statin Induced Myopathy: Histological and Immune Histochemical Study

New Trends in Immunohistochemical Methods to Estimate the Time since Death: A Review

Dormant cardiac stem cells: A promising tool in cardiac regeneration

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