Skeletal Muscle Regenerative Potential of Human MuStem Cells following Transplantation into Injured Mice Muscle

Lorant, Judith; Saury, Charlotte; Schleder, Cindy; Robriquet, Florence; Lieubeau, Blandine; Négroni, Elisa; Leroux, Isabelle; Chabrand, Lucie; Viau, Sabrina; Babarit, Candice; Ledevin, Mireille; Dubreil, Laurence; Hamel, Antoine; Magot, Armelle; Thorin, Chantal; Guével, Laëtitia; Delorme, Bruno; Péreón, Yann; Butler‐Browne, Gillian; Mouly, Vincent; Rouger, Karl

doi:10.1016/j.ymthe.2017.10.013

Cited by 29 publications

(39 citation statements)

References 131 publications

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“…Among these are muscle‐derived stem cells (MDSCs) and CD133+ mesoangioblasts that closely resemble pericytes . MDSCs are not terminally committed to the myogenic lineage and can differentiate into the mesodermal lineages as evidenced by their myogenic, osteogenic, and chondrogenic potential . Transplantation of MDSCs into severe muscle injury models has improved muscle repair and reduced fibrosis, with some of the observed effects being attributed to their secretome .…”

Section: Advances In Treatment Of Local Muscle Injuriesmentioning

confidence: 99%

Cell therapy to improve regeneration of skeletal muscle injuries

Qazi

Duda

Ort

et al. 2019

J cachexia sarcopenia muscle

124

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Diseases that jeopardize the musculoskeletal system and cause chronic impairment are prevalent throughout the Western world. In Germany alone, ~1.8 million patients suffer from these diseases annually, and medical expenses have been reported to reach 34.2bn Euros. Although musculoskeletal disorders are seldom fatal, they compromise quality of life and diminish functional capacity. For example, musculoskeletal disorders incur an annual loss of over 0.8 million workforce years to the German economy. Among these diseases, traumatic skeletal muscle injuries are especially problematic because they can occur owing to a variety of causes and are very challenging to treat. In contrast to chronic muscle diseases such as dystrophy, sarcopenia, or cachexia, traumatic muscle injuries inflict damage to localized muscle groups. Although minor muscle trauma heals without severe consequences, no reliable clinical strategy exists to prevent excessive fibrosis or fatty degeneration, both of which occur after severe traumatic injury and contribute to muscle degeneration and dysfunction. Of the many proposed strategies, cell‐based approaches have shown the most promising results in numerous pre‐clinical studies and have demonstrated success in the handful of clinical trials performed so far. A number of myogenic and non‐myogenic cell types benefit muscle healing, either by directly participating in new tissue formation or by stimulating the endogenous processes of muscle repair. These cell types operate via distinct modes of action, and they demonstrate varying levels of feasibility for muscle regeneration depending, to an extent, on the muscle injury model used. While in some models the injury naturally resolves over time, other models have been developed to recapitulate the peculiarities of real‐life injuries and therefore mimic the structural and functional impairment observed in humans. Existing limitations of cell therapy approaches include issues related to autologous harvesting, expansion and sorting protocols, optimal dosage, and viability after transplantation. Several clinical trials have been performed to treat skeletal muscle injuries using myogenic progenitor cells or multipotent stromal cells, with promising outcomes. Recent improvements in our understanding of cell behaviour and the mechanistic basis for their modes of action have led to a new paradigm in cell therapies where physical, chemical, and signalling cues presented through biomaterials can instruct cells and enhance their regenerative capacity. Altogether, these studies and experiences provide a positive outlook on future opportunities towards innovative cell‐based solutions for treating traumatic muscle injuries—a so far unmet clinical need.

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Section: Advances In Treatment Of Local Muscle Injuriesmentioning

confidence: 99%

Cell therapy to improve regeneration of skeletal muscle injuries

Qazi

Duda

Ort

et al. 2019

J cachexia sarcopenia muscle

124

View full text Add to dashboard Cite

show abstract

“…To support these findings, Lorant et al found that when injecting perivascular stem cells into cryoinjured muscles of scid mice the cells integrated into host tissue and contributed to the production of structural proteins associated with differentiated myofibers. 92 In contrast, when Meng et al delivered muscle-derived pericytes intra-arterially to mice, they found that they did not contribute to the regeneration of muscle. 93 These authors believed the discrepancy in results were due to the differences in experimental techniques, animal models, and outcome measurements.…”

Section: Pericytesmentioning

confidence: 95%

“…Further, this study also showed that when delivered systemically the pericytes can cross the vessel wall to colonize the injured muscle. To support these findings, Lorant et al found that when injecting perivascular stem cells into cryoinjured muscles of scid mice the cells integrated into host tissue and contributed to the production of structural proteins associated with differentiated myofibers . In contrast, when Meng et al delivered muscle‐derived pericytes intra‐arterially to mice, they found that they did not contribute to the regeneration of muscle .…”

Section: Stem Cells For Skeletal Muscle Regenerationmentioning

confidence: 99%

Biomaterial and stem cell‐based strategies for skeletal muscle regeneration

Dunn

Talovic

Patel

et al. 2019

Journal Orthopaedic Research

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Adult skeletal muscle can regenerate effectively after mild physical or chemical insult. Muscle trauma or disease can overwhelm this innate capacity for regeneration and result in heightened inflammation and fibrotic tissue deposition resulting in loss of structure and function. Recent studies have focused on biomaterial and stem cell‐based therapies to promote skeletal muscle regeneration following injury and disease. Many stem cell populations besides satellite cells are implicated in muscle regeneration. These stem cells include but are not limited to mesenchymal stem cells, adipose‐derived stem cells, hematopoietic stem cells, pericytes, fibroadipogenic progenitors, side population cells, and CD133+ stem cells. However, several challenges associated with their isolation, availability, delivery, survival, engraftment, and differentiation have been reported in recent studies. While acellular scaffolds offer a relatively safe and potentially off‐the‐shelf solution to cell‐based therapies, they are often unable to stimulate host cell migration and activity to a level that would result in clinically meaningful regeneration of traumatized muscle. Combining stem cells and biomaterials may offer a viable therapeutic strategy that may overcome the limitations associated with these therapies when they are used in isolation. In this article, we review the stem cell populations that can stimulate muscle regeneration in vitro and in vivo. We also discuss the regenerative potential of combination therapies that utilize both stem cell and biomaterials for the treatment of skeletal muscle injury and disease. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1246–1262, 2019.

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“…34 Other approaches include the use of muscle-derived stem cells (MDSCs). They have been used in animal models of severe muscle injury 35,36 and muscular dystrophy, but there are no clinical studies. MDSCs are multipotent and have osteogenic and chondrogenic as well as myogenic potential, and they may be useful in injuries affecting different tissues such as the myotendinous junction.…”

Section: Cellular Therapiesmentioning

confidence: 99%

Biological Basis of Treatments of Acute Muscle Injuries: A Short Review

Beggs¹

2020

Semin Musculoskelet Radiol

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Muscle strains occur frequently in recreational and professional sports. This article considers various treatment options in a biological context and reviews evidence of their efficacy. Treatments reviewed include the PRICE principle (Protection, Rest, Ice, Compression, Elevation), early mobilization, physical therapy, hematoma aspiration, platelet-rich plasma injections, use of nonsteroidal anti-inflammatory drugs, corticosteroids, and local anesthetics, cellular therapies, and surgery.

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Skeletal Muscle Regenerative Potential of Human MuStem Cells following Transplantation into Injured Mice Muscle

Cited by 29 publications

References 131 publications

Cell therapy to improve regeneration of skeletal muscle injuries

Cell therapy to improve regeneration of skeletal muscle injuries

Biomaterial and stem cell‐based strategies for skeletal muscle regeneration

Biological Basis of Treatments of Acute Muscle Injuries: A Short Review

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