Skeletal muscle regeneration after injury: An overview

Bodine, Sue C.

doi:10.1016/s0892-1997(05)80319-4

Cited by 56 publications

(70 citation statements)

References 57 publications

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“…Although muscle can regenerate, recurrent muscle injuries could affect muscle performance. Skeletal muscle regeneration is well documented, and several studies have shown that regeneration takes place after contusion 3, 4, 5, 6. Contusions are the most common type of muscle injury.…”

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confidence: 99%

Muscle injury in rats induces upregulation of inflammatory cytokines in injured muscle and calcitonin gene–related peptide in dorsal root ganglia innervating the injured muscle

et al. 2016

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Introduction: In this study we evaluated the relationships among the behavioral changes after muscle injury, histological changes, changes in inflammatory cytokines in the injured muscle, and changes in the sensory nervous system innervating the muscle in rats. Methods: We established a model of muscle injury in rats using a dropped weight. Behavior was assessed using the CatWalk system. Subsequently, bilateral gastrocnemius muscles and dorsal root ganglia (DRGs) were resected. Muscles were stained with hematoxylin and eosin, and inflammatory cytokines in injured muscles were assayed. DRGs were immunostained for calcitonin gene–related peptide (CGRP). Results: Changes of behavior and upregulation of inflammatory cytokines in injured muscles subsided within 2 days of injury. Repaired tissue was observed 3 weeks after injury. However, upregulation of CGRP in DRG neurons continued for 2 weeks after injury. Conclusion: These findings may explain in part the pathological mechanism of persistent muscle pain. Muscle Nerve 54: 776–782, 2016

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confidence: 99%

Muscle injury in rats induces upregulation of inflammatory cytokines in injured muscle and calcitonin gene–related peptide in dorsal root ganglia innervating the injured muscle

et al. 2016

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“…Skeletal muscle regeneration has been well documented (1) and several studies have shown that skeletal muscles regenerate after contusion (2)(3)(4)(5).…”

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Regenerated rat skeletal muscle after periodic contusions

Minamoto

Bunho

Salvini

2001

Braz J Med Biol Res

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In the present study we evaluated the morphological aspect and changes in the area and incidence of muscle fiber types of long-term regenerated rat tibialis anterior (TA) muscle previously submitted to periodic contusions. Animals received eight consecutive traumas: one trauma per week, for eight weeks, and were evaluated one (N = 8) and four (N = 9) months after the last contusion. Serial cross-sections were evaluated by toluidine blue staining, acid phosphatase and myosin ATPase reactions. The weight of injured muscles was decreased compared to the contralateral intact one (one month: 0.77 ± 0.15 vs 0.91 ± 0.09 g, P = 0.03; four months: 0.79 ± 0.14 vs 1.02 ± 0.07 g, P = 0.0007, respectively) and showed abundant presence of split fibers and fibers with centralized nuclei, mainly in the deep portion. Damaged muscles presented a higher incidence of undifferentiated fibers when compared to the intact one (one month: 3.4 ± 2.1 vs 0.5 ± 0.3%, P = 0.006; four months: 2.3 ± 1.6 vs 0.3 ± 0.3%, P = 0.007, respectively). Injured TA evaluated one month later showed a decreased area of muscle fibers when compared to the intact one (P = 0.003). Thus, we conclude that: a) muscle fibers were damaged mainly in the deep portion, probably because they were compressed against the tibia; b) periodic contusions in the TA muscle did not change the percentage of type I and II muscle fibers; c) periodically injured TA muscles took four months to reach a muscle fiber area similar to that of the intact muscle.

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“…Muscle fibers injured by strain undergo robust regeneration via the activation of satellite cells [195,196]. Since the nuclei are located peripherally in the myocyte, it is easy to identify fibers that have been injured because regenerating/regenerated muscle fibers have centralized nuclei, which persist for at least 4 months [197].…”

Section: Discussionmentioning

confidence: 99%

Stretching adversely modulates locomotor capacity following spinal cord injury via activation of nociceptive afferents.

Keller¹

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Skeletal muscle regeneration after injury: An overview

Cited by 56 publications

References 57 publications

Muscle injury in rats induces upregulation of inflammatory cytokines in injured muscle and calcitonin gene–related peptide in dorsal root ganglia innervating the injured muscle

Muscle injury in rats induces upregulation of inflammatory cytokines in injured muscle and calcitonin gene–related peptide in dorsal root ganglia innervating the injured muscle

Regenerated rat skeletal muscle after periodic contusions

Stretching adversely modulates locomotor capacity following spinal cord injury via activation of nociceptive afferents.

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