Skeletal muscle RBM3 expression is associated with extended lifespan in Ames Dwarf and calorie restricted mice

Associations between RNA-Binding Motif Protein 3, Fibroblast Growth Factor 21, and Clinical Outcome in Patients with Stroke

“…Although global protein synthesis is inhibited under hypothermia, the expression of a subgroup of mediators known as cold-shock proteins (CSPs) is acutely upregulated following cold exposure [8]. In line with previous in vivo experimental studies [9][10][11][12], we have recently reported that the RNA-binding motif protein 3 (RBM3), a member of CSPs, mediates the good prognosis of ischemic stroke patients with mild body temperatures [13]. Pharmacological induction of RBM3 represents a potential means of neuroprotection for stroke in the absence of hypothermia [14]; however, a drug or agonist that directly targets RBM3 expression or activity has not been developed [14].…”

“…In line with our previous study [13], this new analysis reinforces the hypothesis that RBM3 acts as a promising protective target mediating the good outcome of patients with mild body temperature. These findings are not new, and the protective role of RBM3 has been widely explored and demonstrated in various scenarios, including brain injury, cancer, heart ischemia, and muscle hypertrophy, as a therapeutic target [8][9][10][11][12]. In the absence of a specific agonist, the upstream induction of RBM3 has been evaluated for its potential for use as therapy.…”

RBM3 is an outstanding cold shock protein with multiple physiological functions beyond hypothermia

“…High expression of RBM3 in skeletal muscle suggests that RBM3 exerts a compensatory protective effect to prevent muscle loss in aged rats (Dupont‐Versteegden et al, 2008; Hettinger et al, 2021). Overexpression of RBM3 induces hypertrophy of myotubes and muscle fibers and improves atrophy in rats (Van Pelt et al, 2018).…”

“…High expression of RBM3 in skeletal muscle suggests that RBM3 exerts a compensatory protective effect to prevent muscle loss in aged rats (Dupont-Versteegden et al, 2008;Hettinger et al, 2021).…”

“…RBM3 promotes overall transcription and translation in a variety of ways, enabling cells to respond quickly to environmental signals (Dresios et al, 2005; Smart et al, 2007). RBM3 acts as a stress response protein and participates in multiple cellular physiological processes under various stress conditions such as cold stress, endoplasmic reticulum stress, hypoxia, radiation, excitatory toxins, emaciation, and certain disease states (Feng et al, 2021; Hettinger et al, 2021; Ryan et al, 2005; Shi et al, 2019; X. Zhu et al, 2016, 2019; Zhuang et al, 2017). Furthermore, RBM3 has excellent cytoprotective effects under stress conditions.…”