Skeletal muscle molecular responses to resistance training and dietary supplementation in COPD

Constantin, Despina; Menon, Manoj K.; Houchen–Wolloff, Linzy; Morgan, Michael; Singh, Sally; Greenhaff, Paul L.; Steiner, Michael

doi:10.1136/thoraxjnl-2012-202764

Cited by 68 publications

(99 citation statements)

References 28 publications

(19 reference statements)

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“…Three trials have tested the effect of creatine supplementation during exercise training in COPD with no consistent positive effect, as confirmed by a subsequent systematic review and meta-analysis [105]. In a group of overall non-wasted COPD patients, protein and carbohydrate supplementation after resistance exercise did not augment functional or molecular exercise responses [106]. The question whether nutritional support can augment the performance outcomes of exercise training and pulmonary rehabilitation remains largely unanswered.…”

Section: Nutrition As Ergogenic Aidmentioning

confidence: 99%

Nutritional assessment and therapy in COPD: a European Respiratory Society statement

et al. 2014

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Nutrition and metabolism have been the topic of extensive scientific research in chronic obstructive pulmonary disease (COPD) but clinical awareness of the impact dietary habits, nutritional status and nutritional interventions may have on COPD incidence, progression and outcome is limited. A multidisciplinary Task Force was created by the European Respiratory Society to deliver a summary of the evidence and description of current practice in nutritional assessment and therapy in COPD, and to provide directions for future research. Task Force members conducted focused reviews of the literature on relevant topics, advised by a methodologist. It is well established that nutritional status, and in particular abnormal body composition, is an important independent determinant of COPD outcome. The Task Force identified different metabolic phenotypes of COPD as a basis for nutritional risk profile assessment that is useful in clinical trial design and patient counselling. Nutritional intervention is probably effective in undernourished patients and probably most when combined with an exercise programme. Providing evidence of costeffectiveness of nutritional intervention is required to support reimbursement and thus increase access to nutritional intervention. Overall, the evidence indicates that a well-balanced diet is beneficial to all COPD patients, not only for its potential pulmonary benefits, but also for its proven benefits in metabolic and cardiovascular risk. @ERSpublications Metabolism and nutrition: shifting paradigms in COPD management

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Section: Nutrition As Ergogenic Aidmentioning

confidence: 99%

Nutritional assessment and therapy in COPD: a European Respiratory Society statement

et al. 2014

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“…Interestingly, exercise targets these factors, and exercise training results in elevated levels of basal autophagy 103. However, exercise leads to an increase in muscle mass and strength in COPD patients 98. Moreover, autophagy is required for muscle adaptations to training 103, 104.…”

Section: New Insights In the Pathophysiology Of Muscle Wasting In Chrmentioning

confidence: 99%

“…Although exercise induces oxidative stress, which is even accentuated in COPD patients,105 exercise also triggers myogenesis 106. In COPD, this myogenic response to exercise seems intact, although it is specifically impaired in cachectic COPD 40, 98. Exercise‐induced satellite cell activation is mediated by IGF signalling 107.…”

Section: New Insights In the Pathophysiology Of Muscle Wasting In Chrmentioning

confidence: 99%

Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

Sanders¹,

Kneppers²,

Bool³

et al. 2015

Journal of Cachexia, Sarcopenia and Muscle

115

101

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Cachexia and muscle wasting are well recognized as common and partly reversible features of chronic obstructive pulmonary disease (COPD), adversely affecting disease progression and prognosis. This argues for integration of weight and muscle maintenance in patient care. In this review, recent insights are presented in the diagnosis of muscle wasting in COPD, the pathophysiology of muscle wasting, and putative mechanisms involved in a disturbed energy balance as cachexia driver. We discuss the therapeutic implications of these new insights for optimizing and personalizing management of COPD‐induced cachexia.

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“…В этих исследованиях изучался эффект добавления креатина в рацион больных ХОБЛ в период фи зических тренировок, однако стойкого положитель ного результата не получено, что было отмечено в последующем систематическом обзоре и мета анализе [105]. У больных ХОБЛ без дефицита МТ в целом при добавлении белков и углеводов после резистивной нагрузки не наблюдалось усиления функционального и молекулярного ответа [106]. Вопрос, может ли нутритивная поддержка усилить функциональный результат физической тренировки и легочной реабилитации, остается открытым.…”

Section: клинические рекомендацииunclassified

Evaluation of nutritional status and nutritional therapy in chronic obstructive pulmonary disease

Редакционная¹

2016

Pulʹmonologiâ (Mosk.)

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Skeletal muscle molecular responses to resistance training and dietary supplementation in COPD

Cited by 68 publications

References 28 publications

Nutritional assessment and therapy in COPD: a European Respiratory Society statement

Nutritional assessment and therapy in COPD: a European Respiratory Society statement

Cachexia in chronic obstructive pulmonary disease: new insights and therapeutic perspective

Evaluation of nutritional status and nutritional therapy in chronic obstructive pulmonary disease

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