Skeletal Muscle in Healthy Subjects versus Those with<i>GNE</i>-Related Myopathy: Evaluation with Shear-Wave US—A Pilot Study

Carpenter, Elizabeth L.; Lau, Heather; Kolodny, Edwin H.; Adler, Ronald S.

doi:10.1148/radiol.2015142212

Cited by 56 publications

(57 citation statements)

References 12 publications

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“…Moreover, in a relaxed unloaded muscle, the shear wave velocity is slower in the longitudinal plane than in the transverse, but as the muscle is loaded, the velocity in the longitudinal plane increases and exceeds the transverse [29]. Nevertheless, our results are in agreement with those reported for the rectus femoris muscle by Carpenter et al [30]. We found that both systems were affected by anisotropy in the transverse and oblique planes to the same extent, as velocities increased and became less stable.…”

Section: Discussionsupporting

confidence: 93%

An investigation into the variability between different shear wave elastography systems in muscle

et al. 2017

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Aims: The reliability and agreement between shear wave elastography (SWE) systems using different acquisition methods in muscles is not yet established. The objectives were to determine the reliability of a new SWE system on normal resting muscles using different acquisition methods and to compare its performance to an established state-of-the-art system.Material and methods: Small, medium and large ROI sizes in addition to longitudinal, oblique and transverse orientations over five different locations within the rectus femoris muscle were tested using the new system. Results were compared to the established system to test for inter-system reproducibility.Results: Lowest within-subject coefficient of variance (4.3%) andshear wave velocity (1.83 m/s) were associated with the medium ROI and longitudinal orientation from the lateral location. This combination resulted in a strong internal agreement of intra-class correlation of 0.76 (0.57–0.89) for the new system and an almost perfect agreement of 0.92 (0.82–0.97) for the established. Inter-system reproducibility for the best combination was 0.71 (0.48–1) with a mean velocity difference ±95% limits of agreement of 0.07±0.49 m/s.Conclusions: Altering SWE acquisition methods can produce variable results. The new system produced reliable results that are comparable with but not as reliable as the established.

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Section: Discussionsupporting

confidence: 93%

An investigation into the variability between different shear wave elastography systems in muscle

et al. 2017

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“…Histologically, IM shows perivascular and/or perimysial and/or endomysial infiltration of inflammatory cells, often associated with perifascicular atrophy or microinfarcts. 22 The results of our study are in agreement with those of previous studies, which have shown that inflammatory lesions of the pancreas, bowel and uterus have relatively high SR. 20,23,24 Although the target organs were different in our study, there were similar histologic features. Chronic pancreatitis is characterized by pancreatic infiltration of inflammatory cells.…”

Section: Discussionsupporting

confidence: 48%

“…12,[16][17][18][19] Although IM have been previously studied using conventional ultrasonography and MRI, there are only a few studies in the literature that have attempted to use SSE in IM. 12,20 Furthermore, there are no published data available for the pathologic correlation of myositis including muscle stiffness.…”

Section: Introductionmentioning

confidence: 99%

Strain sonoelastography of inflammatory myopathies: comparison with clinical examination, magnetic resonance imaging and pathologic findings

Song¹,

Lee²,

Yoo³

et al. 2016

BJR

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were assessed with SSE after MRI. The ratio of strain in the target muscle (A) and a nearby normal muscle (B), defined as the strain index value (SR) (B/A), was calculated automatically. Elastograms were assigned an elasticity score according to the degree and distribution of strain induced by manual compression. Ultrasonography and MRI were analyzed in conjunction with clinical information, biochemical data, final clinical diagnosis and grading of pathology. Correlations between SR and qualitative analyses of MRI and ultrasonography, elasticity score, biochemical data and final clinical diagnosis were analyzed using Pearson's correlation coefficient.Results: The SR of the target muscles was high in patients with IM (mean 3.14; range, 0.95-5.93 6 1.42). The correlations between SR and pathologic grading and elasticity score were statistically significant (p , 0.05). There was no significant agreement between SR and other clinical and radiologic parameters. Conclusion: Muscle hardness, as semi-quantitatively measured by SSE, was increased in cases of IM. The correlation between the SR and the pathologic grading suggests that SSE could be an important tool in not only the diagnosis of but also in measuring the degree of muscular inflammation. Advances in knowledge: This work describes a correlation between tissue elasticity and pathology in IM.

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“…During the past few years, several studies have been published on SWE of human tendons (5-17) and muscles (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), with promising results. The majority of these studies are experimental (5,6,(9)(10)(11)(12)(13)(14)(16)(17)(18)(19)(20)(21)(22)(23)(24)27,29,(31)(32)(33) with a smaller number of clinical studies (7,8,15,26,28,30,34,35).…”

Section: Swe Of Tendons and Musclesmentioning

confidence: 99%

“…Promising results have been published in the recent literature on the utility of SWE in the evaluation of several traumatic and pathologic conditions of various musculoskeletal soft tissues, including tendons (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), muscles (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), nerves (30)(31)(32), and ligaments (33)(34)(35).…”

Section: Introductionmentioning

confidence: 99%

Shear-Wave Elastography: Basic Physics and Musculoskeletal Applications

et al. 2017

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In the past 2 decades, sonoelastography has been progressively used as a tool to help evaluate soft-tissue elasticity and add to information obtained with conventional gray-scale and Doppler ultrasonographic techniques. Recently introduced on clinical scanners, shearwave elastography (SWE) is considered to be more objective, quantitative, and reproducible than compression sonoelastography with increasing applications to the musculoskeletal system. SWE uses an acoustic radiation force pulse sequence to generate shear waves, which propagate perpendicular to the ultrasound beam, causing transient displacements. The distribution of shear-wave velocities at each pixel is directly related to the shear modulus, an absolute measure of the tissue's elastic properties. Shear-wave images are automatically coregistered with standard B-mode images to provide quantitative color elastograms with anatomic specificity. Shear waves propagate faster through stiffer contracted tissue, as well as along the long axis of tendon and muscle. SWE has a promising role in determining the severity of disease and treatment followup of various musculoskeletal tissues including tendons, muscles, nerves, and ligaments. This article describes the basic ultrasound physics of SWE and its applications in the evaluation of various traumatic and pathologic conditions of the musculoskeletal system.

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Skeletal Muscle in Healthy Subjects versus Those withGNE-Related Myopathy: Evaluation with Shear-Wave US—A Pilot Study

Abstract: SWV parametric imaging may provide a useful quantitative adjunct in the assessment of disease activity in patients with GNE-related myopathy. There is diminished SWV and muscle anisotropy in GNE-related myopathy.

Cited by 56 publications

References 12 publications

An investigation into the variability between different shear wave elastography systems in muscle

An investigation into the variability between different shear wave elastography systems in muscle

Strain sonoelastography of inflammatory myopathies: comparison with clinical examination, magnetic resonance imaging and pathologic findings

Shear-Wave Elastography: Basic Physics and Musculoskeletal Applications

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