Skeletal muscle IL-6 regulates muscle substrate utilization and adipose tissue metabolism during recovery from an acute bout of exercise

Knudsen, Janne Lehmann; Gudiksen, Anders; Bertholdt, Lærke; Overby, Peter; Villesen, Ida; Schwartz, Camilla Victoria Lindgren; Pilegaard, Henriette

doi:10.1371/journal.pone.0189301

Cited by 28 publications

(28 citation statements)

References 42 publications

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“…Insulin has previously been shown to inhibit hepatic autophagy [ 26 ], and it could be speculated that the increase in autophagy markers in the resting and recovery groups was a result of food intake and hence elevated plasma insulin levels. However, data from our group has demonstrated that insulin does not increase until 10 h into recovery after an exercise bout [ 22 ]. This is in accordance with the present observation that food intake was markedly increased 10 h into recovery.…”

Section: Discussionmentioning

confidence: 99%

PGC-1α in exercise and fasting-induced regulation of hepatic UPR in mice

Kristensen

Olsen

Jessen

et al. 2018

Pflugers Arch - Eur J Physiol

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The aim of the present study was to test the hypothesis that PGC-1α is involved in the regulation of hepatic UPR and autophagy in response to both exercise and fasting in mice. Liver-specific PGC-1α knockout (LKO) mice and their floxed littermates (lox/lox) were used in two experimental parts. Liver and plasma were obtained from (1) fed and 18 h fasted mice and (2) immediately after, 2, 6, and 10 h after 1-h treadmill running as well as from resting mice, where one resting group was euthanized at time points corresponding to 0 and 2 h and another corresponding to 6 and 10 h of recovery. Hepatic eIF2α phosphorylation and sXBP1 mRNA content increased immediately after exercise and IRE1α phosphorylation as well as cleaved ATF6 protein content was higher 2 h into recovery than at rest in both genotypes. Fasting reduced hepatic IRE1α phosphorylation and protein content as well as PERK protein and sXBP1 mRNA content similarly in lox/lox and LKO mice. In addition, the hepatic LC3II/LC3I protein ratio increased immediately after exercise and with fasting in both genotypes, while fasting decreased p62 protein content in lox/lox mice. Liver-specific PGC-1α knockout did not affect these responses, but the LC3II/LC3I protein ratio was higher in LKO than lox/lox mice in both rest groups. In conclusion, the present study provides evidence for pathway-specific exercise-induced activation and fasting-induced downregulation of the UPR as well as exercise and fasting-induced regulation of autophagy in mouse liver. In addition, overall PGC-1α does not seem to be required for the fasting and exercise-induced regulation of UPR and autophagy, but may be involved in regulating basal hepatic autophagy.

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Section: Discussionmentioning

confidence: 99%

PGC-1α in exercise and fasting-induced regulation of hepatic UPR in mice

Kristensen

Olsen

Jessen

et al. 2018

Pflugers Arch - Eur J Physiol

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“…On the contrary, the mechanism of action of myokines can also require their release in the circulation to be delivered to their target tissue(s). Examples of such mechanisms include the stimulation of fatty acid oxidation and glucose uptake into white adipose tissue by IL-6 during exercise recovery (Knudsen et al, 2017) and the positive effect of IL-13 on both rat and human pancreatic β-cell survival (Rutti et al, 2016). This underscores the different mechanisms of action of myokines depending on their release locally in skeletal muscle [muscle protein and messenger RNA (mRNA)] and in the circulation (plasma or serum protein).…”

Section: Introductionmentioning

confidence: 99%

Plasma Myokine Concentrations After Acute Exercise in Non-obese and Obese Sedentary Women

et al. 2020

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Exercise and physical activity levels influence myokine release from skeletal muscle and contribute to circulating concentrations. Indeed, many myokines, including interleukin (IL)-6, IL-15, secreted protein acidic rich in cysteine (SPARC), and fibroblast growth factor (FGF) 21 are higher in the circulation after an exercise bout. Since these peptides modulate muscle metabolism and can also be targeted toward other tissues to induce adaptations to energy demand, they are of great interest regarding metabolic diseases. Therefore, we set out to compare, in six women with obesity (BMI ≥30 kg/m 2 ) and five healthy women (BMI 22-29.9 kg/m 2 ), the effect of an acute bout of moderate-intensity, continuous cycling exercise (60 min, 60% VO 2 peak) on the release of myokines (IL-6, IL-8, IL-10, IL-13, IL-15, SPARC, and FGF21) in plasma for a 24-h time course. We found that plasma IL-8 and SPARC levels were reduced in the group of women with obesity, whereas plasma IL-13 concentrations were elevated in comparison to nonobese women both before and after the exercise bout. We also found that plasma FGF21 concentration during the 24 h following the bout of exercise was regulated differently in the non-obese in comparison to obese women. Plasma concentrations of FGF21, IL-6, IL-8, IL-15, and IL-18 were regulated by acute exercise. Our results confirm the results of others concerning exercise regulation of circulating myokines while providing insight into the time course of myokine release in circulation after an acute exercise bout and the differences in circulating myokines after exercise in women with or without obesity.

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“…Previous studies have reported that adipose tissue is the main source of inflammatory mediators, especially IL-6. 22 Moreover, they pointed out the importance of IL-6 in this coexistence, further proving that the two diseases were interrelated.…”

Section: Discussionmentioning

confidence: 96%

<p>The Synchronous Presence of Multiple Myelomas and Other Primary Malignant Tumors: Case Series with Literature Review</p>

Liu

Song

et al. 2020

CMAR

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The synchronous presence of multiple myeloma (MM) and other primary malignant tumors (PMTs) were rarely reported. This study aimed to analyze several cases of MM and other PMTs in order to improve clinicians' understanding of multiple myeloma (MM) with sMPMTs. Methods: This study was a retrospective trial. We retrospectively analyzed six cases of the synchronous presence of MM and other PMTs and reviewed the literature to summarize the clinical features and treatment. Results: The results showed that five cases of immunoglobulin G (IgG) and one case of kappa light chain; D-S stage: six case of stage III; ISS stage: one case of stage I, two cases of stage II, and three cases of stage III; one case each of gastric cancer (pT2N0MO, stage I), breast cancer (pT1bN0M0, stage I), lung cancer (pT1N0M0, stage I), cervical cancer (stage IB2), thyroid cancer (pT1N0M0, stage I), and diffuse large B-cell lymphoma (Ann-Arbor stage II); three of five patients underwent surgery alone, one patient underwent surgery first and then received chemotherapy at the time of pleural metastasis and the other patient only received radiotherapy; two patients were still alive, three died of progression of MM, and one died of lung cancer. The median survival time was 33.5 months (95% CI, 14.17 to 59.5months). Conclusion: The relationship between synchronous MM and other PMTs remains unknown. Clinicians should improve their understanding of MM with sMPMTs by carrying out multidisciplinary collaboration and a patient-oriented approach to optimize treatment and prolong the survival rates of patients.

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Skeletal muscle IL-6 regulates muscle substrate utilization and adipose tissue metabolism during recovery from an acute bout of exercise

Cited by 28 publications

References 42 publications

PGC-1α in exercise and fasting-induced regulation of hepatic UPR in mice

PGC-1α in exercise and fasting-induced regulation of hepatic UPR in mice

Plasma Myokine Concentrations After Acute Exercise in Non-obese and Obese Sedentary Women

<p>The Synchronous Presence of Multiple Myelomas and Other Primary Malignant Tumors: Case Series with Literature Review</p>

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