Skeletal muscle-gut axis: emerging mechanisms of sarcopenia for intestinal and extra intestinal diseases

Sire, Roberto de; Rizzatti, Gianenrico; Ingravalle, Fabio; Pizzoferrato, Marco; Petito, Valentina; Lopetuso, Loris Riccardo; Graziani, C.; Sire, Alessandro de; Mentella, Maria Chiara; Mele, Maria Cristina; Gasbarrini, Antonio; Scaldaferri, Franco

doi:10.23736/s1121-421x.18.02511-4

Cited by 62 publications

(57 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Besides, most phyloytpes in Allobaculum and Blautia can produce short-chain fatty acids (SCFAs), which were reported to enter the systemic circulation and be absorbed by muscle cells, and work in alleviating inflammation and promoting insulin sensitivity [37][38][39]. Besides, SCFA promotes the release of glucagon-like eptide-1, which increases GLUT4 gene expression and glucose uptake in skeletal muscle [40]. Tea water extracts attenuated HFD-induced metabolism disorders and modulated gut microbiota in mice with increased abundance of Ruminococcaceae [41].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antidiabetic Effect of Casein Glycomacropeptide Hydrolysates on High-Fat Diet and STZ-Induced Diabetic Mice via Regulating Insulin Signaling in Skeletal Muscle and Modulating Gut Microbiota

et al. 2020

View full text Add to dashboard Cite

This study evaluated the effects and the underlying mechanisms of casein glycomacropeptide hydrolysate (GHP) on high-fat diet-fed and streptozotocin-induced type 2 diabetes (T2D) in C57BL/6J mice. Results showed that 8-week GHP supplementation significantly decreased fasting blood glucose levels, restored insulin production, improved glucose tolerance and insulin tolerance, and alleviated dyslipidemia in T2D mice. In addition, GHP supplementation reduced the concentration of lipopolysaccharides (LPSs) and pro-inflammatory cytokines in serum, which led to reduced systematic inflammation. Furthermore, GHP supplementation increased muscle glycogen content in diabetic mice, which was probably due to the regulation of glycogen synthase kinase 3 beta and glycogen synthase. GHP regulated the insulin receptor substrate-1/phosphatidylinositol 3-kinase/protein kinase B pathway in skeletal muscle, which promoted glucose transporter 4 (GLUT4) translocation. Moreover, GHP modulated the overall structure and diversity of gut microbiota in T2D mice. GHP increased the Bacteroidetes/Firmicutes ratio and the abundance of S24-7, Ruminiclostridium, Blautia and Allobaculum, which might contribute to its antidiabetic effect. Taken together, our findings demonstrate that the antidiabetic effect of GHP may be associated with the recovery of skeletal muscle insulin sensitivity and the regulation of gut microbiota.

show abstract

Section: Discussionmentioning

confidence: 99%

“…LPS inhibits insulin gene expression in a TLR-4 dependent way and via NF-κB signaling in human pancreatic islets [43]. Low muscle glycogen levels were accompanied by increased IL-6 which could induce insulin resistance [40]. Therefore, modulating gut microbiota is an effective way to restore insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic Effect of Casein Glycomacropeptide Hydrolysates on High-Fat Diet and STZ-Induced Diabetic Mice via Regulating Insulin Signaling in Skeletal Muscle and Modulating Gut Microbiota

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It is important to note that with the exception of (Walsh et al, 2015), the studies referenced in this mini-review have been performed in young mice and humans. Studies aimed at investigation of the gut-muscle axis in older adults are limited, as discussed in previous reviews (de Sire et al, 2018;Grosicki et al, 2018;Ni Lochlainn et al, 2018;Picca et al, 2018;Ticinesi et al, 2019). Recent findings from our group add to elucidation of the gut-muscle axis in older adults.…”

Section: Role Of the Gut Microbiome And Short-chain Fatty Acids On Phmentioning

confidence: 96%

“…A role for the gut microbiome on the maintenance of whole body lean mass, skeletal muscle mass, and physical functioning (defined as the gut-muscle axis) has been proposed by several independent research groups (de Sire et al, 2018;Grosicki et al, 2018;Ni Lochlainn et al, 2018;Picca et al, 2018;Ticinesi et al, 2019). A negative role for the gut microbiome on the maintenance of whole body lean mass was first suggested based on a pioneering study by (Backhed et al, 2004).…”

Section: Role Of the Gut Microbiome On Whole Body Lean Massmentioning

confidence: 99%

The Role of the Gut Microbiome on Skeletal Muscle Mass and Physical Function: 2019 Update

Lustgarten

2019

Front. Physiol.

View full text Add to dashboard Cite

Within the past year, several studies have reported a positive role for the gut microbiome on the maintenance of skeletal muscle mass, evidence that contrasts previous reports of a negative role for the gut microbiome on the maintenance of whole body lean mass. The purpose of this mini-review is to clarify these seemingly discordant findings, and to review recently published studies that further elucidate the gut-muscle axis.

show abstract

“…Then, suppression of MAPK and FoxO signaling pathways are important mechanisms for ameliorating in ammation and provoking apoptosis in RA patients [42] . Finally, pathways responsible for reducing reactive oxygen species [43] are of vital importance of anti-RA treatment focused on excessive in ammation. These enriched pathways unravel a network characteristic of GERA against RA as a multi-component, multitarget and multi-pathway pattern.…”

Section: Network Pharmacology Unraveled Crucial Anti-ra Targets Of Geramentioning

confidence: 99%

The Anti-RA Activities of a Couplet Medicinals, Gastrodia Elata and Radix Aconitic Lateralis preparata, Explored by Untargeted Metabolomics and Network Pharmacology.

Yang¹,

Shen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background The couplet Medicinals, Gastrodia Elata and Radix Aconitic Lateralis preparata (GERA), is an established formula extensively used in Chinese medicine for treating rheumatoid arthritis (RA). However, the anti-RA mechanisms of GERA are still unclear. This paper aims to explore the anti-RA mechanisms of GERA by a combined strategy of untargeted metabolomics and network pharmacology. Methods Three water extracts were prepared as propotions: Gastrodia Elata compared with Radix Aconitic Lateralis (w/w): 1:1, 3:2, or 2:3. The untargeted metabolomics were executed with UPLC-MS. The metabolites were annotated and identified by Human metabolome database (HMDB) and Lipid maps database. Finally, key genes and pathways related to anti-RA activities of GERA were mined by network pharmacology. Results The untargeted metabolomics profile displayed that four differentially expressed metabolites were involved in isoflavonoid biosynthesis and biosynthesis of unsaturated fatty acids (p < 0.05). Among these differential metabolites, the essential ingredients of GERA were linoleic acid, daidzein, and daidzin. The principal targets of anti-RA activities of GERA were IL-6, TNF, VEGFA, TP53, CASP3 and PTGS2. Thirty anti-RA targets of GERA were majorly belonged to pathways response for anti-inflammation, endothelial function and apoptosis, suggesting the fundamental process of RA treatment. Conclusion The anti-RA activities of GERA were based on the inhibition of inflammation and regulation of endothelial function and apoptosis.

show abstract

Skeletal muscle-gut axis: emerging mechanisms of sarcopenia for intestinal and extra intestinal diseases

Cited by 62 publications

References 104 publications

Antidiabetic Effect of Casein Glycomacropeptide Hydrolysates on High-Fat Diet and STZ-Induced Diabetic Mice via Regulating Insulin Signaling in Skeletal Muscle and Modulating Gut Microbiota

Antidiabetic Effect of Casein Glycomacropeptide Hydrolysates on High-Fat Diet and STZ-Induced Diabetic Mice via Regulating Insulin Signaling in Skeletal Muscle and Modulating Gut Microbiota

The Role of the Gut Microbiome on Skeletal Muscle Mass and Physical Function: 2019 Update

The Anti-RA Activities of a Couplet Medicinals, Gastrodia Elata and Radix Aconitic Lateralis preparata, Explored by Untargeted Metabolomics and Network Pharmacology.

Contact Info

Product

Resources

About