Skeletal Muscle Fatigue

Kent‐Braun, Jane A.; Fitts, Robert H.; Christie, Anita

doi:10.1002/cphy.c110029

Cited by 169 publications

(167 citation statements)

References 382 publications

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“…Although a sex difference in fatigability was not apparent during the dynamic task, men experienced greater relative reductions in maximal force than women at the end of the dynamic task with the knee extensor muscles. Fatigue of maximal force is due to fewer high force cross-bridges and/or less force per cross-bridge, but reductions in maximal velocity contractions is related to the speed of cross-bridge cycling and calcium kinetics in the fibre [see (Kent-Braun et al, 2012) for review]. Greater insight into sex differences in the rate limiting mechanisms of dynamic contractions could be gained from experiments that fatigue human single fibres during shortening contractions in vitro .…”

Section: Sex Differences In Muscle Fatigue Are Task Specificmentioning

confidence: 99%

“…When contractions are sustained or repeated, however, as they are during exercise, rehabilitation and many daily activities, the relative reduction in force and power can differ between men and women when performed at the same relative intensity of contraction. This activity-induced reduction in force or power is known as muscle fatigue (Gandevia, 2001, Enoka and Duchateau, 2008, Kent-Braun et al, 2012) or fatigability (Kluger et al, 2013). In this review the terminology is used interchangeably.…”

Section: Introductionmentioning

confidence: 99%

“…(Gandevia, 2001, Enoka and Duchateau, 2008, Kent-Braun et al, 2012)], there is still a tremendous lack of knowledge and appreciation of sex-based differences in fatigability and the prevailing mechanisms under different task conditions. This is, in part, because of the historical and current bias of studying proportionally more males than females in both human and animal-based physiology (Anonymous, 2010, Kim et al., 2010, Zucker and Beery, 2010, Beery and Zucker, 2011, Cahill, 2012, Miller, 2012) and the presumption that sex differences in fatigability do not exist.…”

Section: Introductionmentioning

confidence: 99%

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Sex differences in human fatigability: mechanisms and insight to physiological responses

2014

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Sex-related differences in physiology and anatomy are responsible for profound differences in neuromuscular performance and fatigability between men and women. Women are usually less fatigable than men for similar intensity isometric fatiguing contractions. This sex difference in fatigability, however, is task specific because different neuromuscular sites will be stressed when the requirements of the task are altered, and the stress on these sites can differ for men and women. Task variables that can alter the sex difference in fatigue include the type, intensity and speed of contraction, the muscle group assessed, and the environmental conditions. Physiological mechanisms that are responsible for sex-based differences in fatigability may include activation of the motor neuron pool from cortical and subcortical regions, synaptic inputs to the motor neuron pool via activation of metabolically-sensitive small afferent fibres in the muscle, muscle perfusion, and skeletal muscle metabolism and fibre type properties. Non-physiological factors such as the sex bias of studying more males than females in human and animal experiments can also mask a true understanding of the magnitude and mechanisms of sex-based differences in physiology and fatigability. Despite recent developments, there is a tremendous lack of understanding of sex differences in neuromuscular function and fatigability, the prevailing mechanisms and the functional consequences. This review emphasises the need to understand sex-based differences in fatigability in order to shed light on the benefits and limitations that fatigability can exert for men and women during daily tasks, exercise performance, training and rehabilitation in both health and disease.

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Section: Sex Differences In Muscle Fatigue Are Task Specificmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sex differences in human fatigability: mechanisms and insight to physiological responses

2014

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“…Changes in the electrical excitability of muscle, both acquired and inherited, are established causes of compromised muscle function in humans. A reduction of muscle fiber excitability may cause symptomatic weakness, as experienced commonly with fatigue during strenuous exercise (120). More severe derangements of fiber excitability are the primary cause of several inherited disorders of skeletal muscle and are the focus of this review.…”

Section: Disorders Of Skeletal Muscle Excitabilitymentioning

confidence: 99%

Channelopathies of Skeletal Muscle Excitability

Cannon

2015

Comprehensive Physiology

170

176

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Familial disorders of skeletal muscle excitability were initially described early in the last century and are now known to be caused by mutations of voltage-gated ion channels. The clinical manifestations are often striking, with an inability to relax after voluntary contraction (myotonia) or transient attacks of severe weakness (periodic paralysis). An essential feature of these disorders is fluctuation of symptoms that are strongly impacted by environmental triggers such as exercise, temperature, or serum K+ levels. These phenomena have intrigued physiologists for decades, and in the past 25 years the molecular lesions underlying these disorders have been identified and mechanistic studies are providing insights for therapeutic strategies of disease modification. These familial disorders of muscle fiber excitability are “channelopathies” caused by mutations of a chloride channel (ClC-1), sodium channel (NaV1.4), calcium channel (CaV1.1) and several potassium channels (Kir2.1, Kir2.6, Kir3.4). This review provides a synthesis of the mechanistic connections between functional defects of mutant ion channels, their impact on muscle excitability, how these changes cause clinical phenotypes, and approaches toward therapeutics.

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“…In addition, contractile fatigability was not quantified using standard methods such as reduction in motor responses elicited with peripheral nerve stimulation. 8 Therefore, the influence of chronic exposure to endurance training on peripheral and central fatigue both for standardized amount of work and at task failure in comparison with untrained individuals needs to be specifically investigated.…”

Section: Introductionmentioning

confidence: 99%

Original Research: Central and peripheral quadriceps fatigue in young and middle-aged untrained and endurance-trained men: A comparative study

Bachasson

Decorte

Wuyam

et al. 2016

Exp Biol Med (Maywood)

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This study aimed to compare quadriceps function (i.e. strength, endurance, central, and peripheral fatigue) of young (Young-UnTr) and middle-aged (MidAge-UnTr) untrained men and young endurance-trained men (Young-Tr). Twenty-four male subjects (eight Young-UnTr (26 AE 4 yr), eight Young-Tr (29 AE 3 yr), and eight MidAge-UnTr (56 AE 4 yr) performed a maximal cycling test to assess their fitness level. On a separate visit, subjects performed sets of 10 intermittent (5-s on/5-s off) isometric contractions starting at 10% maximum voluntary contraction (MVC), with 10% MVC increments from one set to another until exhaustion. Electrophysiological and mechanical (e.g. twitch) evoked responses elicited with magnetic femoral nerve stimulation in the relaxed muscle and during MVC (i.e. estimation of voluntary activation using the interpolated twitch technique) were measured at baseline and after each set to assess peripheral and central fatigue, respectively. Endurance (¼ total number of contractions) was also evaluated. Young-UnTr exhibited larger reductions in evoked quadriceps mechanical responses than MidAge-UnTr and Young-Tr after identical standardized muscle loading (e.g. after the 50% MVC set, reduction in single potentiated twitch was À36 AE 9%, À21AE16%, and À2 AE 4%, respectively). At both 50% MVC set and exhaustion, MidAge-UnTr exhibited similar reduction in maximal voluntary activation and displayed similar endurance compared to Young-UnTr. Young-Tr exhibited greater endurance than Young-UnTr without significant changes in maximal voluntary activation throughout the test. This study provides robust comparative data regarding the influence of chronic exposure to endurance training and middle-aged on central and peripheral quadriceps fatigability and endurance. Endurance-trained subjects showed smaller level of peripheral fatigue and displayed no significant central fatigue, even at exhaustion and despite greater endurance performance. Our findings also demonstrate that men in the sixth decade exhibit significant alterations in quadriceps function typically observed in much older subjects. These data emphasize the need for developing normative data for both central and peripheral quadriceps fatigability.

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Skeletal Muscle Fatigue

Cited by 169 publications

References 382 publications

Sex differences in human fatigability: mechanisms and insight to physiological responses

Sex differences in human fatigability: mechanisms and insight to physiological responses

Channelopathies of Skeletal Muscle Excitability

Original Research: Central and peripheral quadriceps fatigue in young and middle-aged untrained and endurance-trained men: A comparative study

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