Skeletal Muscle Adaptation in Response to Supervised Exercise Training for Intermittent Claudication

Beckitt, T.A.; Day, Jude; Morgan, M.; Lamont, PM

doi:10.1016/j.ejvs.2012.07.002

Cited by 15 publications

(18 citation statements)

References 36 publications

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“…Studies show that this type of WE prescription increases pain-free walking distance over time via improvements in skeletal muscle perfusion and/or oxygenation (3,36). However, its effect on systemic cardiovascular function and blood pressure (BP) responses has received little attention despite a body of literature reporting postexercise hypotension (PEH) effects in other populations with hypertension (6,10,14,22,23,29,30,(32)(33)(34).…”

mentioning

confidence: 99%

Post-Walking Exercise Hypotension in Patients with Intermittent Claudication

Cucato

Chehuen

Ritti‐Dias

et al. 2015

Medicine &Amp; Science in Sports &Amp; Exercise

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mentioning

confidence: 99%

Post-Walking Exercise Hypotension in Patients with Intermittent Claudication

Cucato

Chehuen

Ritti‐Dias

et al. 2015

Medicine &Amp; Science in Sports &Amp; Exercise

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“…41 Multiple methods were employed to assess muscle size, with consistency between three studies adopting a computed tomography scanning procedure. 31,34,36 The symptomatic limb was significantly smaller than the asymptomatic limb in calf circumference and cross-sectional area 13 ; however, wide 95% CIs indicate a heterogeneous group (Table III, A). Those with PAD-IC were found to have significantly smaller calf…”

Section: Resultsmentioning

confidence: 95%

“…Of the 13 studies reporting changes to fiber type, size, or capillarity (Table IV, A-D), 12,13,[15][16][17][18][19][20]23,24,27,36,42 5 studies made comparisons to an asymptomatic limb, 13,16,17,19,20 5 made comparisons to a control group, 12,13,17,27,42 and 4 investigated the effects of an intervention. 20,23,24,26 Reported measures included fiber type proportions (nine studies), fiber size (eight studies), and measures relating to capillarity (three studies).…”

Section: Journal Of Vascular Surgerymentioning

confidence: 99%

A systematic review of muscle morphology and function in intermittent claudication

Harwood

King

Totty

et al. 2017

Journal of Vascular Surgery

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Previous literature has found clear evidence that strength (of the calf and thigh musculature) and calf characteristics are related to mortality and functional declines. However, this review has demonstrated the vast array of muscle groups assessed and multiple methods employed to determine strength; therefore, it is unclear exactly what measure of "strength" is impaired. Furthermore, the underlying morphologic causes of potential changes in strength are unclear. This information is essential for designing optimal exercise interventions. The data acquired during this systematic review are heterogeneous, with a substantial lack of high-quality intervention-based studies. Future research should endeavor to establish standardized testing procedures and to implement randomized controlled trials for targeted therapeutic interventions.

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“…Several PAD studies have reported that the benefit obtained from walking exercise may be due to an improvement in skeletal muscle adaptation and metabolism as well as the oxidative capacity of the active muscles. 38,39 A number of studies have shown that exercise rehabilitation for IC does not improve blood flow to the leg 40,41 although several studies have reported modest improvements. 30,42 Other possible mechanisms for the improvement in walking ability include an improvement in walking economy (rate of oxygen consumption in relation to distance completed), 43,44 increased angiogenesis, 45 a decrease in blood viscosity, 46 improvement in endothelial function, 47 a decrease in atherosclerosis and an increase in pain tolerance.…”

Section: Introductionmentioning

confidence: 99%

Community walking programs for treatment of peripheral artery disease

Mays

Rogers

Hiatt

et al. 2013

Journal of Vascular Surgery

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Background Supervised walking programs offered at medical facilities for patients with peripheral artery disease (PAD) and intermittent claudication (IC), while effective, are often not utilized due to barriers including lack of reimbursement and the need to travel to specialized locations for the training intervention. Walking programs for PAD patients that occur in community settings, such as those outside of supervised settings, may be a viable treatment option, as they are convenient and potentially bypass the need for supervised walking. This review evaluated the various methodologies and outcomes of community walking programs for PAD. Methods A literature review using appropriate search terms was conducted within PubMed/Medline and the Cochrane databases to identify studies in the English language employing community walking programs to treat PAD patients with IC. Search results were reviewed, and relevant articles were identified that form the basis of this review. The primary outcome was peak walking performance on the treadmill. Results Randomized controlled trials (n=10) examining peak walking outcomes in 558 PAD patients demonstrated that supervised exercise programs were more effective than community walking studies that consisted of general recommendations for patients with IC to walk at home. Recent community trials that incorporated more advice and feedback for PAD patients in general resulted in similar outcomes with no differences in peak walking time compared to supervised walking exercise groups. Conclusions Unstructured recommendations for patients with symptomatic PAD to exercise in the community are not efficacious. Community walking programs with more feedback and monitoring offer improvements in walking performance for patients with claudication and may bypass some obstacles associated with facility-based exercise programs.

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Skeletal Muscle Adaptation in Response to Supervised Exercise Training for Intermittent Claudication

Abstract: Supervised exercise training for claudication results in an increase in the proportion of MHC type I expression within the symptomatic gastrocnemius muscle.

Cited by 15 publications

References 36 publications

Post-Walking Exercise Hypotension in Patients with Intermittent Claudication

Post-Walking Exercise Hypotension in Patients with Intermittent Claudication

A systematic review of muscle morphology and function in intermittent claudication

Community walking programs for treatment of peripheral artery disease

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