Skeletal metastases: what is the future role for nuclear medicine?

Cook, Gary

doi:10.1007/s00259-009-1240-8

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…A possible direction for increased accuracy in whole-body screening for skeletal metastases may include the addition of diffusion-weighted imaging sequences. Future technical innovation may include the development of hybrid scanners 76 or integrative postprocessing software for the amalgamation of both nuclear medicine and MRI modalities.…”

Section: Resultsmentioning

confidence: 99%

“…Different patterns of FDG uptake have been reported among osteoblastic, osteolytic, or mixed lesions indicating that sclerotic lesions are less FDG-avid. 76 Future investigation is still required regarding the postchemotherapeutic characterization of osseous metastases with FDG PET because in treated patients no hypermetabolism may be identified. 77 In 2007, Schmidt et al directly compared WBMRI to PET-CT in the evaluation of bone metastases in 30 patients with a variety of primary malignancies.…”

Section: Positron Emission Tomography/positron Emission Tomography-comentioning

confidence: 99%

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Whole-Body Magnetic Resonance Imaging: Assessment of Skeletal Metastases

Moynagh¹,

Colleran²,

Tavernaraki³

et al. 2010

Semin Musculoskelet Radiol

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Section: Resultsmentioning

confidence: 99%

Section: Positron Emission Tomography/positron Emission Tomography-comentioning

confidence: 99%

Whole-Body Magnetic Resonance Imaging: Assessment of Skeletal Metastases

Moynagh¹,

Colleran²,

Tavernaraki³

et al. 2010

Semin Musculoskelet Radiol

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“…Our findings are in line with those of numerous authors who showed the diagnostic accuracy of the SPECT/CT technique to be near 100%. [33][34][35][36] conclusions The applied credibility criteria for the assessment of a solitary hot spot in the spine allow for the direction of diagnosis mainly towards the lesions of noncancerous nature.…”

Section: -15mentioning

confidence: 99%

Reliability of different radioisotopic techniques in diagnosing solitary hot spots in the spine of patients with malignant neoplasm

Górska-Chrząstek¹,

Kovacevicz-Kuśmierek²,

Chrząstek³

et al. 2013

Polish Archives of Internal Medicine

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IntroductIonThe skeletal system together with parenchymal organs, such as the liver and lungs, are the most common sites of metastases. In prostate and breast cancer, bone metastases can be observed in 47% to 85% of the patients, while in the lung, urinary bladder, and kidney cancer, they are present in 30% to 45% of the cases. The most common site of bone metastases is the lumbosacral segment of the spine. 1,2The early diagnosis of metastases to the skeletal system in patients with malignant tumors is particularly important for further therapeutic management. An accurate diagnosis of solitary hot spots in the spine is crucial in patients who are referred for bone scintigraphy. AbstrActIntroductIon Early diagnosis of spinal metastases is of key importance in further therapeutic management.

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“…Cependant, cette technique est peu sensible pour le diagnostic de l'atteinte intramédullaire précoce, pour la détection des métastases purement lytiques, ou pour différencier atteinte active et processus de cicatrisation, les deux induisant une accélération du turnover osseux. Enfin, cette technique n'est pas spécifique de malignité, un accroissement du renouvellement osseux pouvant s'observer dans de nombreuses autres situations (infection, traumatisme, affection métabolique ou dégénérative), ce qui justifie alors le recours à la tomodensitométrie (scanner), les deux informations étant désormais disponibles simultanément sur les machines hybrides [11,15,21,38]. L'introduction de la technologie TEP a constitué une avancée majeure, permettant un gain substantiel en termes de qualité d'image (contraste, résolution, visualisation tridimensionnelle) et de précision topographique [9,30].…”

Section: Introductionunclassified

Role of positron emission tomography with fluorine 18 in the assessment of bony metastases

Even-Sapir

Foult

2010

Oncologie

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18F-fluoride is a positronemitting bone-seeking agent, the uptake of which reflects blood flow and remodeling of bone. Taking advantage of the favorable pharmacokinetic properties of the tracer combined with the high performance of PET technology, 18F-fluoride PET is a highly sensitive imaging modality for detection of benign and malignant osseous abnormalities. 18F-fluoride not only detects osteoblastic lesions but also detects lytic and early marrow-based metastases, by identifying their accompanying reactive osteoblastic changes, even when minimal. The instant fusion of 18F-fluoride data with morphological data of CT using hybrid PET/CT systems improves the specificity of 18F-fluoride PET in cancer patients, accurately differentiating between benign and malignant sites of uptake. 18F-fluoride PET and PET/CT is, however, not widely used in clinical practice. The limited availability of 18F-fluoride PET and PET/CT systems is a major factor. However, it has been stated by some experts that 18F-fluoride PET/CT is expected to replace 99m-Tc-MDP bone scintigraphy or act as a solving problem technology in specific clinical scenarios.Keywords: F18-Fluoride -PET/ CT -Bone metastasis -Osteoblastic lesions -Bone scintigraphy Résumé : Le fluor-18 (18F) est un radioélément ayant une forte affinité pour les tissus osseux, émet-teur de positons, dont la fixation reflète le flux sanguin et le remodelage osseux. Combinant les propriétés pharmacocinétiques favorables de ce traceur et les hautes performances de la technologie TEP, la 18F-TEP est une technique d'imagerie hautement sensible pour la détection des lésions osseuses bénignes et malignes. Le 18F permet de détecter non seulement les lésions ostéoblastiques, mais aussi les lésions lytiques et les métastases médullaires préco-ces, en identifiant les changements ostéoblastiques réactifs qui les accompagnent, même lorsqu'ils sont minimes. La fusion instantanée des données du 18F et des données morphologiques de la TDM, au moyen de systèmes hybrides TEP/TDM, améliore la spécificité de la 18F-TEP chez les patients atteints de cancer, en permettant de distinguer avec préci-sion les sites de fixation bénins des sites malins. La 18F-TEP et la TEP/TDM ne sont toutefois pas largement utilisées dans la pratique clinique. Cela est principalement dû à la faible disponibilité du 18F et des systèmes TEP/TDM. Cependant, certains experts affirment que la 18F-TEP/TDM devrait remplacer la scintigraphie osseuse au 99mTc-MDP ou constituer une technologie permettant la résolu-tion de problèmes, dans des situations cliniques spécifiques.

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Skeletal metastases: what is the future role for nuclear medicine?

Cited by 7 publications

References 29 publications

Whole-Body Magnetic Resonance Imaging: Assessment of Skeletal Metastases

Whole-Body Magnetic Resonance Imaging: Assessment of Skeletal Metastases

Reliability of different radioisotopic techniques in diagnosing solitary hot spots in the spine of patients with malignant neoplasm

Role of positron emission tomography with fluorine 18 in the assessment of bony metastases

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