Skeletal maturity leads to a reduction in the strain magnitudes induced within the bone: A murine tibia study

Razi, Hajar; Birkhold, Annette; Zaslansky, Paul; Weinkamer, Richard; Duda, Georg N.; Willie, Bettina M.; Checa, Sara

doi:10.1016/j.actbio.2014.11.021

Cited by 75 publications

(86 citation statements)

References 39 publications

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“…However, as suggested by previous studies [50], strains may match at the site of the strain gauge, but this does not ensure that strain levels are similar in both age groups throughout the entire tibiae. In a previous study, we have shown that in young and adult animals, although strains match at the strain gauge site, at the anterior and posterior regions strains induced within young animals are higher than in adult mice [50,72].…”

Section: Discussionmentioning

confidence: 85%

Skeletal maturation substantially affects elastic tissue properties in the endosteal and periosteal regions of loaded mice tibiae

et al. 2015

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Section: Discussionmentioning

confidence: 85%

Skeletal maturation substantially affects elastic tissue properties in the endosteal and periosteal regions of loaded mice tibiae

et al. 2015

Self Cite

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“…Using novel image registration techniques and FE models, Razi et al [52] showed that load-induced strain magnitudes at the cortical middiaphysis were significantly reduced with aging (20 % lower in adult versus young mice, 15 % lower in aged versus adult mice) due to alterations of whole bone morphology. This shift was also observed in trabecular bone.…”

Section: Anabolic Strain Threshold: Refinement Of the Mechanostatmentioning

confidence: 98%

Bone Homeostasis and Repair: Forced Into Shape

Castillo

Leucht

2015

Curr Rheumatol Rep

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Mechanical loading is a potent anabolic regulator of bone mass, and the first line of defense for bone loss is weight-bearing exercise. Likewise, protected weight bearing is the first prescribed physical therapy following orthopedic reconstructive surgery. In both cases, enhancement of new bone formation is the goal. Our understanding of the physical cues, mechanisms of force sensation, and the subsequent cellular response will help identify novel physical and therapeutic treatments for age- and disuse-related bone loss, delayed- and nonunion fractures, and significant bony defects. This review highlights important new insights into the principles and mechanisms governing mechanical adaptation of the skeleton during homeostasis and repair and ends with a summary of clinical implications stemming from our current understanding of how bone adapts to biophysical force.

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“…Due to the curvature of the bone, the tibial mid-diaphysis is loaded in bending and compression, as described elsewhere [51]. Formation sites in the loaded limbs were mainly localized at anterior (tension) and posterior regions (compression), whereas resorption could be visualized as a "band" between these two regions.…”

Section: Totalmentioning

confidence: 99%

Monitoring in vivo (re)modeling: A computational approach using 4D microCT data to quantify bone surface movements

Birkhold

Razi

Weinkamer

et al. 2015

Bone

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Skeletal maturity leads to a reduction in the strain magnitudes induced within the bone: A murine tibia study

Cited by 75 publications

References 39 publications

Skeletal maturation substantially affects elastic tissue properties in the endosteal and periosteal regions of loaded mice tibiae

Skeletal maturation substantially affects elastic tissue properties in the endosteal and periosteal regions of loaded mice tibiae

Bone Homeostasis and Repair: Forced Into Shape

Monitoring in vivo (re)modeling: A computational approach using 4D microCT data to quantify bone surface movements

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