Skeletal manifestations of granulocytic sarcoma (chloroma)

Hermann, George; Feldman, Frieda; Abdelwahab, Ibrahim Fikry; Klein, Michael J.

doi:10.1007/bf00194248

Cited by 23 publications

(9 citation statements)

References 11 publications

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“…GS occurs in about 5 percent of acute myeloid leukemia (AML) cases and may be the initial manifestation of the disease [2,3]. Diagnosis is particularly difficult if bone marrow is not available for cytological analysis (dry tap) [4,5]. The poorly differentiated nature of cells, which may resemble those of large cell lymphoma [3,[6][7][8], constitutes a problem to pathologists.…”

Section: Introductionmentioning

confidence: 99%

Osteolytic lesions as a presenting sign of acute myeloid leukemia

et al. 2000

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Osteolytic lesions rarely occur in acute myeloid leukemia (AML). We reported an atypical form of the disease, with marrow fibrosis and osteolytic lesions, in a 17-year-old patient, whose main symptom was lumbar pain. Diagnosis of AML was established by bone marrow and lymph node histological analysis. Computed tomography (CT) scan and 99mTc-MDP bone scintyscan revealed osteolytic lesions. After remission-induction, bone marrow aspirate and biopsy showed no evidence of leukemic infiltration, nevertheless bone abnormalities persisted on 99mTc-MDP bone scintyscan, suggesting residual disease. Suspect bone areas were irradiated with symptomatic improvement and 99mTc-MDP bone scintyscan showed the appearance of more condensed bone compared with the pre-radiotherapy pattern. Twelve months later he was readmitted to the hospital due to relapse of AML and died of sepsis within a few weeks. This report illustrates the usefulness of histological studies to establish diagnosis of AML in atypical cases, as well as the importance of CT scan and bone scintigraphy scan for the identification of osteolytic lesions. It also provides additional data as evidence that although osteolytic lesions indicate an adverse prognosis in AML, local irradiation results symptomatic relief.

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Section: Introductionmentioning

confidence: 99%

Osteolytic lesions as a presenting sign of acute myeloid leukemia

et al. 2000

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“…Lytic lesions are typically found to be solid collections of leukemic cells, i.e. solitary myeloid sarcoma or chloroma [14]. Though common in multiple myeloma and malignancy, only four other published cases of pathologically benign lytic lesions in patients with myelofibrosis were found (in English speaking literature).…”

Section: Discussionmentioning

confidence: 99%

Multi-focal Lytic Lesions in a Patient with Myelofibrosis: A Case Report

Burnham

Johnson

Lomasney

et al. 2020

Cureus

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Myelofibrosis is a rare disorder that is classified as one of the myeloproliferative disorders. This particular disorder results in the abnormal proliferation of hematopoietic stem cells in the bone marrow. In some cases, such as ours, pathologic fractures can occur due to skeletal manifestations. We report on a rare finding of rapidly progressive lytic lesions in multiple regions throughout the body. This presentation of myelofibrosis behaving in a metastatic-like fashion has not been previously described.

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“…Sıklıkla akut ve kronik miyeloid lösemiler olmak üzere diğer miyeloproliferatif hastalıklara eşlik eder. [2][3][4][5][6][7][8] Daha nadir olarak miyeloid sarkom, herhangi bir hematolojik hastalık olmadan da görülebilmektedir. Bu durum da primer, izole veya lösemik olmayan miyeloid sarkom olarak adlandırılmaktadır.…”

Section: Discussionunclassified

“…Akut miyeloid lösemi, kronik miyeloid lösemi, miyelodisplastik sendrom, hipereosinofilik sendrom, polisitemia vera gibi hematolojik patolojilerde görülebilen oldukça nadir bir tümördür. [2][3][4][5][6][7][8][9][10][11] En sık orbita ve paranazal sinüslerde görülmekle birlikte gastrointestinal sistem, plevra, kalp, bronşlar ve santral sinir sisteminde de görülebilir. Ekstremitelerde oldukça nadir görülür.…”

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