Skeletal Fluorosis: An Unusual Manifestation of Computer Cleaner Inhalant Abuse

Abstract

Skeletal fluorosis is a metabolic bone disease caused by accumulation of fluoride and is generally associated with chronic exposure to fluoride-contaminated groundwater, a phenomenon endemic to developing countries. Whereas elevated water fluoride concentrations do not constitute a public health issue in the United States, emergence of skeletal fluorosis as a sequela of chronic recreational exposures has been described. In this case report, our 33-yearold male patient with a history of major depressive disorder and substance abuse was hospitalized for hyperkalemia and acute kidney injury discovered on routine bloodwork due to concomitant nonsteroidal anti-inflammatory drugs (NSAID) and antihypertensive use. Upon hospital admission, he was found to be anemic with a significantly elevated alkaline phosphatase. Given a history of low back pain in the setting of these laboratory abnormalities, lower spine and pelvic imaging revealed diffusely increased bone density and sclerosis. Hematologic evaluation ensued to include a peripheral smear and bone marrow biopsy. Given the patient's history of computer cleaner inhalant abuse, serum and urinary fluoride levels were obtained. Serum fluoride returned within normal limits though urinary fluoride was increased. Bone marrow histopathology revealed prominent diffuse sclerosis which in conjunction with urinary fluoride levels and computer cleaner inhalant abuse history supported the diagnosis of skeletal fluorosis. Skeletal fluorosis in the United States is rare and presents with non-specific findings requiring a high index of suspicion based on a detailed patient history for expedient diagnosis.

Skeletal Fluorosis: A Case of Inhalant Abuse Leading to a Diagnosis of Colon Cancer

“… 4 - 6 In the United States, skeletal fluorosis is rare and has been reported to develop via uncommon means of toxicity including toothpaste ingestion, excessive tea consumption, voriconazole treatment, and inhalant abuse. 6 - 10 …”

“…[4][5][6] In the United States, skeletal fluorosis is rare and has been reported to develop via uncommon means of toxicity including toothpaste ingestion, excessive tea consumption, voriconazole treatment, and inhalant abuse. [6][7][8][9][10] Diagnosis, particularly in the United States, can prove to be difficult because the condition is not commonly seen by clinicians. In addition, the differential for the presentation can be broad and includes metabolic disorders, malignancy, and hematologic disorders.…”

Skeletal Fluorosis in a Patient With Computer Cleaner Inhalant Abuse

“…Skeletal fluorosis can be caused by excessive consumption of fluoride from fluoride-contaminated water or foods. Such a condition is endemic in developing areas of countries such as India and China [1][2]. Overingestion of fluoride may alter bone development, remodeling, and metabolism by increasing osteoblast activity and periostitis, leading to back pain, bone tenderness, joint immobility or deformity, and arthralgias [1][2][3][4].…”

“…Such a condition is endemic in developing areas of countries such as India and China [1][2]. Overingestion of fluoride may alter bone development, remodeling, and metabolism by increasing osteoblast activity and periostitis, leading to back pain, bone tenderness, joint immobility or deformity, and arthralgias [1][2][3][4]. Complications include pathologic bone fractures, osteoporosis, and osteomalacia [1][2][3].…”

“…Overingestion of fluoride may alter bone development, remodeling, and metabolism by increasing osteoblast activity and periostitis, leading to back pain, bone tenderness, joint immobility or deformity, and arthralgias [1][2][3][4]. Complications include pathologic bone fractures, osteoporosis, and osteomalacia [1][2][3]. Few case reports have presented rare cases of skeletal fluorosis in the United States from recreational substance misuse, such as computer cleaner inhalants, fluoride-containing air dust cleaner, and surreptitious excessive toothpaste consumption [1][2][3][5][6].…”