Skeletal Demineralization and Growth Retardation in Inflammatory Bowel Disease

Genant, Harry K.; Mall, Jay C.; Wagonfeld, James B.; Horst, Jean Vander; Lanzi, Lawrence H.

doi:10.1097/00004424-197611000-00007

Cited by 50 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cortical bone mineral content, although not trabecular, correlates with body mass index in patients with IBD (159) and dietary intakes of manganese, magnesium, copper, zinc, and vitamin K (although the presence of actual micronutrient deficiencies was not evaluated) (160). Growth failure related to both retarded skeletal maturation and linear rowth in children has also been associated with the use of corticosteroids in children with IBD, although this may also be related to the underlying disease (161)(162)(163).…”

Section: Malnutrition and Micronutrient Deficienciesmentioning

confidence: 99%

Bones and Crohn's: Problems and solutions

Buchman

2007

Inflamm Bowel Dis

View full text Add to dashboard Cite

Inflammatory bowel disease may manifest in various extra intestinal manifestations. Osteopenia and various arthropathies may be debilitating. These may be related to the disease itself, patient genetics, lifestyle, or disease treatment. Calcium and vitamin D malabsorption, vitamin K deficiency, malnutrition, corticosteroid and other immunosuppressive medications, smoking, lack of exercise and postmenopausal state may all play important roles. Treatment may be undertaken to correct nutrient deficiencies, inhibit bone resorption and increase bone formation.

show abstract

Section: Malnutrition and Micronutrient Deficienciesmentioning

confidence: 99%

Bones and Crohn's: Problems and solutions

Buchman

2007

Inflamm Bowel Dis

View full text Add to dashboard Cite

show abstract

“…C ROHN'S DISEASE HAS BEEN ASSOClated with malabsorption of a variety of n u trients ( 1-4) and with growth failure (5)(6)(7)(8)(9). Vitamin D absorption and serum vitamin D levels have been reported to be abnormal in patients with inflammatory bowel disease ( I 0), although not all studies have shown this (10)(11)(12)(13)(14)(15)(16)(17).…”

mentioning

confidence: 99%

Disorders of Mineral and Bone Metabolism in Patients with Crohn's Disease

Westarp¹,

Thomson²,

Overton³

et al. 1987

Canadian Journal of Gastroenterology

View full text Add to dashboard Cite

Crohn's disease is known to produce malabsorption of calcium and vitamin D which affect the skeleton. A variety of techniques were used to assess the prevalence of mineral and bone abnormalities in 53 consecutive patients with Crohn's disease. Twenty healthy controls were compared with 28 men and 25 women with Crohn's disease. In males, the mean corrected serum calcium concentration was elevated, the mean winter plasma 25-hydroxyvitamin D was low, as was the bone volume on biopsy and the fractional absorption of {7Ca. In females, the corrected serum calcium was also higher than in contro ls, as was the serum alkaline phosphatase activity. The female patients had significant decreases in both summer and winter plasma vitamin D leve ls, metacarpa l cortica l thickness and fractional absorption of 47 Ca. The disturbances in bone and mineral metabolism were generally mild and were not associated with use of glucocorticosteroids but were more severe in patients with a history of bowel resection. Thus, patients with C ro hn's disease are at risk of developing metabolic bone disease and consideration should be given for an assessment of the skeleton in patients with Crohn's disease. especially in women and in patients with previous ilea! resection. A battery of tests may be needed to exclude the diagnosis of metabo lic bo ne disease but a 25-hydroxyvitamin D assay and hand x·rays using industrial grade film are recommended as a valuable preliminary assessment.Can) Gastroe nterol 1987;1(1):l l-17 (23) and th e published normal population was used as the control groups with whom the Bone metabolism In Crohn's disease TABLE4 patients, fractional calcium absorption from the gut was measured using a rad ioisotope method similar to that described by Chanard et al (33). The protocol was as follows: on day 1 of the test the subject received 1.0 µCi47CaZ+ as calcium chloride in travenously after an 8 h fast. fuur hours later, while still fasting, the radioactivity in the concralaceral fo rearm was measured usi ng a low background, two crystal gamma ray spectrometer. On day 3 of the study, fo llowing another 8 h fast, residual activity in the forearm was measured immediately before the subject received an oral dose of 4 µCi47CaH together with 180 mg elemental calcium (as 10% gl uconate). Four hours following this oral dose, while still fasting, the forear m radioactiv ity was again measured. Fractional calcium absorption was calculated as fo llows:Plasma 25-hydroxyvitamin D and percentage fractional calcium absorption T he gamma ray spectrometer system, specially constructed for these measurements, was carefully calibrated and arm positioning devices were used to assure consistent repeat m easurements of fo rearm radioactivity. The radiation background of the gamma ray spectrometer system was low and stable a nd was screened against radioactivity from pans of the subject's body other than the measu red forearm . For normal subjects. the error in the measurement (including Table 2 Vol. 1 No. 1. October 1987 cou n ti...

show abstract

“…Genant compared cortical thickness of the metacarpal in subjects with IBD with that of a normal reference series and found that values were at least one standard deviation below the normal means in most subjects [14]. Assessment of spine density by x-ray in these subjects showed a similar demineralization.…”

Section: Inflammatory Bowel Disease (Ibd)mentioning

confidence: 90%

Osteoporosis and aging: gastrointestinal aspects.

Dawson‐Hughes¹

1986

Journal of the American College of Nutrition

View full text Add to dashboard Cite

Skeletal Demineralization and Growth Retardation in Inflammatory Bowel Disease

Cited by 50 publications

References 0 publications

Bones and Crohn's: Problems and solutions

Bones and Crohn's: Problems and solutions

Disorders of Mineral and Bone Metabolism in Patients with Crohn's Disease

Osteoporosis and aging: gastrointestinal aspects.

Contact Info

Product

Resources

About