Skeletal 90Sr as a marker of migration activity of murine rodents in the zone of the Eastern Ural Radioactive Trace

Starichenko, V.I.; Lyubashevskiy, N. M.; Modorov, M. V.; Chibiryak, M. V.

doi:10.1134/s1067413614030126

Cited by 9 publications

(5 citation statements)

References 5 publications

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“…While analyzing the radiation exposure of the animals, it should be taken into account that the doses are affected by a migration, which is discussed e.g. in [19]. Different levels of contamination would causes uneven daily 90 Sr intake that would change the pattern of dose cumulating.…”

Section: Discussionmentioning

confidence: 99%

“…Measured skeletal Sr activity concentration that determines the dose rate on the last day before trapping may be used as a marker of migration. According to [19] in the most contaminated area, 10% of mice and voles are migrants.…”

Section: Discussionmentioning

confidence: 99%

“…90 Sr activity in the long bones was measured using conventional method of ashed bone radiometry [7,19]. Starichenko et al [19] published a review of the data on skeletal 90 Sr activity in mice and voles inhabiting territories of EURT with different levels of surface contamination. A total of 1042 animals were used for the study.…”

Section: Methodsmentioning

confidence: 99%

“…At the same time, about 70% of animals had changes in blood count, structure and function of the cells and chromosomes (increased frequency of chromosomal aberrations and micronuclei), symptoms of immunosuppression and other non-lethal pathologies [12,18,19]. That's why their adaptation can not be considered as perfect.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of radiation exposure of murine rodents at the EURT territories

et al. 2014

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The study provides data on contemporary levels of radiation exposure of organs and tissues of murine rodents (several species of mice and voles) inhabiting the East-Ural Radioactive Trace. The estimation procedure involves the most advanced approach based on application of appropriate voxel phantom and biokinetic model. Input data for dose assessment are the results of measurements of skeletal 90Sr activity concentration. Maximal internal dose to skeleton, accumulated during 45 days, is 303 mGy. Median internal dose rates on the last day before trapping were 0.83, 0.092 and 0.023 mGy/day for animals trapped at the sites with initial (1957) 90Sr surface contamination >37 MBq/m2, 18.5–37 MBq/m2 and 0.074–18.5 MBq/m2 respectively. Taking to account internal and external exposures, upper boundary of the ICRP Derived Consideration Reference Level (DCRL) is exceeded on the territory with maximal level of the initial 90Sr surface contamination. On the territory with 18.5–37 MBq/m2, whole body mean dose rates to murine rodents exceed the lower boundary of DCRL. On the areas with lower level of surface contamination, even the 90-th percentile of dose rate is below the DCRL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of radiation exposure of murine rodents at the EURT territories

et al. 2014

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“…The data on radiation effects should be supported by radiation dosimetry. Internal BM exposure due to 90 Sr incorporation can be based on the information about skeleton contamination (Starichenko 2004;Starichenko et al 2014). In Shishkina et al (2021a) the data on 90 Sr skeleton contamination of herb field mouse (Sylvaemus uralensis) obtained during long-term (2003 -2012 years) study were summarized.…”

Section: Dosimetry Of Rodents Exposed At the East Urals Radioactive T...mentioning

confidence: 99%

Bone marrow dosimetry for mice: exposure from bone-seeking 89,90Sr

Shishkina

Shuiskaya

Sharagin

2022

Radiat Environ Biophys

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Studies of radiobiological effects in murine rodents exposed to internal radiation in the wild or in laboratory experiments require a dosimetric support. The main problem of bone marrow (BM) dosimetry for boneseeking β-emitters is dosimetric modeling due to the fact that the bone is a heterogeneous structure with complex microarchitecture. To date, there are several approaches to calculating the absorbed dose in BM, which mostly use rough geometric approximations. Recently, in the framework of studies of people exposed to 90 Sr in the Urals, a new approach (SPSD) has been developed. The aim of current study was to pilot test the possibility of extension of the SPSD-approach elaborated for humans to mice. The computational phantoms of femur bones of laboratory animals (C57BL/6, C57BL/6J, BALB/c, BALB/cJ) aged 5-8 weeks (growing) and >8 weeks (adults) were created. The dose factors to convert the 89,90 Sr activity concentrations in a bone tissue into units of the dose rate absorbed in the bone marrow were estimated as follows: DFSr-90(BMTBV+CBV) is equal to 1.75±0.42 and 2.57±0.93 (μGy day -1 ) per (Bq g -1 ) for growing and adults, respectively; DFSr-89(BMTBV+CBV) is equal to 1.08±0.27 and 1.66±0.67 (μGy day -1 ) per (Bq g -1 ) for growing and adults, respectively. These results are about 2.5 times lower than skeleton-average DF, calculated assuming the homogenous bone, where source and target coincide. The study demonstrates the possibility of application of the SPSD-approach elaborated for humans to non-human mammals.

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Hematological indicators in pygmy wood mouse Apodemus uralensis (Muridae, Rodentia) populations as markers of the environmental radiation exposure: East Urals radioactive trace (Russia)

Orekhova

2018

Environ Sci Pollut Res

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The hematological effects of chronic radiation exposure in males of the pygmy wood mouse (Apodemus uralensis Pall., 1811) from the East Urals radioactive trace (EURT) area were assessed, taking into account population abundance and reproductive status (immature, ripening, and mature yearlings). For this purpose, we analyzed the morpho-functional characteristics of erythrocytes (red cell indices [MCV, MCH, MCHC], red cell count, activity of antioxidant enzymes [GSH-Px, CAT], lipid peroxidation, glycolysis, osmotic resistance, methaemoglobin content) and blood plasma components (free hemoglobin, total lipids, total cholesterol, and glucose) in the background territory and the EURT area; these areas have a density of soil contamination with Sr of 12,851 and 198 kBq × m, respectively (four and two order of magnitude higher than the background value). The data indicate the "hyperfunctional" state of the erythrocyte, aimed at activation of the gas transport function of blood in the radioactive environment. This, as a consequence, determines the insufficiency of energy supply of the cell defense system necessary to maintain the structural integrity of the membrane. Intensification of membrane lipid peroxidation, reduction of osmotic resistance and GSH-Px activity in red cells, an increase in the degree of intravascular hemolysis, and tendency towards erythropenia indicate the processes of accelerated aging of erythrocytes and their more pronounced destruction in the circulatory bed. The level of the hematological response increased with increasing radiation burden and was more pronounced with a large population size. The interaction effect of "overpopulation" and "radioactive pollution" was observed to a lesser degree for ripening males, and was very small for sexually mature animals. Immature males from the EURT head part with internal whole-body radiation doses of 0.0045-0.35 mGy/day can be considered as the most sensitive group to the factors synergy, including radiation damage and overabundance population.

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Skeletal 90Sr as a marker of migration activity of murine rodents in the zone of the Eastern Ural Radioactive Trace

Cited by 9 publications

References 5 publications

Assessment of radiation exposure of murine rodents at the EURT territories

Assessment of radiation exposure of murine rodents at the EURT territories

Bone marrow dosimetry for mice: exposure from bone-seeking 89,90Sr

Hematological indicators in pygmy wood mouse Apodemus uralensis (Muridae, Rodentia) populations as markers of the environmental radiation exposure: East Urals radioactive trace (Russia)

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