Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38

Kurata, Kouichi; Kawahara, Hideaki; Nishimura, Kohji; Jisaka, Mitsuo; Yokota, Kazushige; Shimizu, Hidehisa

doi:10.1016/j.bbrc.2019.01.122

Cited by 48 publications

(29 citation statements)

References 34 publications

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“…105 Several studies have revealed that microbiota-dependent tryptophan metabolites, such as indole, serve an important role in maintaining intestinal homeostasis through AHR activation. 106,107 These observations suggest tryptophan metabolites and AHR activation potential are involved in the etiology or progression of IBD, thus providing a promising target of therapeutic or nutritional intervention for IBD treatment.…”

Section: Ahr and Inflammatory Bowel Diseasementioning

confidence: 99%

The aryl hydrocarbon receptor as a mediator of host-microbiota interplay

Dong

Perdew

2020

Gut Microbes

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Section: Ahr and Inflammatory Bowel Diseasementioning

confidence: 99%

The aryl hydrocarbon receptor as a mediator of host-microbiota interplay

Dong

Perdew

2020

Gut Microbes

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“…However, IPA is not an efficient AhR ligand [39]. Indole metabolite, skatole (3-methylindole) is an efficient ligand for AhR, but also demonstrates AhR-independent activation of p38 in intestinal epithelial cells [58]. Tryptamine mediates ionic flux in the intestines directly, via a 5-HT 4 receptor (5-HT 4 R), a G-protein-coupled receptor (GPCR) [59].…”

Section: Indole and Its Microbial Metabolites As Promiscuous Ligands For A Given Receptor And Across Receptor Systemsmentioning

confidence: 99%

Drug Mimicry: Promiscuous Receptors PXR and AhR, and Microbial Metabolite Interactions in the Intestine

Dvořák

Sokol

Mani

2020

Trends in Pharmacological Sciences

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“…Skatole is an aryl hydrocarbon receptor agonist, which induces the expression of aryl hydrocarbon receptor regulatory genes, such as CYP1A2. Indole affect intestinal permeability and host immunity 27 . Skatole were shown to be pneumotoxic to humans and associated with hepatic encephalopathy and saccharo-butyric putrefaction 7 – 10 .…”

Section: Discussionmentioning

confidence: 99%

Chicken-eaters and pork-eaters have different gut microbiota and tryptophan metabolites

Shi

Zhao

Fan

et al. 2021

Sci Rep

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This study was aimed to evaluate the differences in the composition of gut microbiota, tryptophan metabolites and short-chain fatty acids in feces between volunteers who frequently ate chicken and who frequently ate pork. Twenty male chicken-eaters and 20 male pork-eaters of 18 and 30 years old were recruited to collect feces samples for analyses of gut microbiota composition, short-chain fatty acids and tryptophan metabolites. Chicken-eaters had more diverse gut microbiota and higher abundance of Prevotella 9, Dialister, Faecalibacterium, Megamonas, and Prevotella 2. However, pork-eaters had higher relative abundance of Bacteroides, Faecalibacterium, Roseburia, Dialister, and Ruminococcus 2. In addition, chicken-eaters had high contents of skatole and indole in feces than pork-eaters, as well as higher contents of total short chain fatty acids, in particular for acetic acid, propionic acid, and branched chain fatty acids. The Spearman’s correlation analysis revealed that the abundance of Prevotella 2 and Prevotella 9 was positively correlated with levels of fecal skatole, indole and short-chain fatty acids. Thus, intake of chicken diet may increase the risk of skatole- and indole-induced diseases by altering gut microbiota.

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Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38

Cited by 48 publications

References 34 publications

The aryl hydrocarbon receptor as a mediator of host-microbiota interplay

The aryl hydrocarbon receptor as a mediator of host-microbiota interplay

Drug Mimicry: Promiscuous Receptors PXR and AhR, and Microbial Metabolite Interactions in the Intestine

Chicken-eaters and pork-eaters have different gut microbiota and tryptophan metabolites

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