SKAP2 acts downstream of CD11b/CD18 and regulates neutrophil effector function
Panagiota Bouti,
Bart J. A. M. Klein,
Paul J. H. Verkuijlen
et al.
Abstract:BackgroundThe importance of CD11b/CD18 expression in neutrophil effector functions is well known. Beyond KINDLIN3 and TALIN1, which are involved in the induction of the high-affinity binding CD11b/CD18 conformation, the signaling pathways that orchestrate this response remain incompletely understood.MethodWe performed an unbiased screening method for protein selection by biotin identification (BioID) and investigated the KINDLIN3 interactome. We used liquid chromatography with tandem mass spectrometry as a pow… Show more
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