Sjögren Syndrome in Primary Salivary Gland Lymphoma

Travaglino, Antonio; Giordano, Claudia; Pace, Mirella; Varricchio, Silvia; Picardi, Marco; Pane, Fabrizio; Staibano, Stefania; Mascolo, Massimo

doi:10.1093/ajcp/aqaa005

Cited by 16 publications

(6 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reason for this female predominance may be influenced by the higher rate of SS among women and the known association of salivary gland MALT lymphoma and SS. In salivary gland MALT lymphoma, the prevalence of SS is 33.3% in our study and 29.5%~78% 19,20,22,23 in literature. Multiple salivary glands are involved in eight of 24 patients with SS in our cohort, a similar result reported by Anacak et al 22 …”

Section: Discussionsupporting

confidence: 44%

“…The development of MALT lymphoma is correlated with chronic inflammatory or autoimmune disorders. SS, which is reported in 29.5%–78% cases and 33.3% (24/72) in our cohort, is strongly associated with salivary gland MALT lymphoma 19–23 . Apart from the microbial virulent factors, patients with salivary MALT lymphoma were found to harbor molecular changes including MALT1 translocation, trisomy 3, and trisomy 18, and from the aforementioned aberrations, trisomy 3 was the most commonly detected aberration 11,20 .…”

Section: Discussionmentioning

confidence: 48%

See 1 more Smart Citation

Clinicopathological aspects of primary mucosa‐associated lymphoid tissue lymphoma of the salivary gland: A retrospective single‐center analysis of 72 cases

Zhang

Xia

et al. 2021

J Oral Pathology Medicine

View full text Add to dashboard Cite

Background Salivary gland extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue lymphoma (MALT lymphoma) is uncommon and has not been studied extensively. We aimed to investigate the features of clinicopathological and molecular changes of salivary MALT lymphoma. Methods Seventy‐two cases of primary salivary MALT lymphoma that had clinicopathological information available were utilized in this study. MALT1 gene translocation, trisomy 3, and trisomy 18 were detected by interphase fluorescence in situ hybridization (FISH). The data were analyzed using SPSS 17.0 software package. Results The ratio of male to female was 1:2.8, and the median age was 57.0 years. 12.5% (9/72) of the patients presented with multiple swellings. Among the others with solitary mass, the parotid gland was involved most frequently (47/63,74.6%), followed by the palate (7/63, 11.1%). 34.7% of patients had an autoimmune disease, with Sjögren syndrome (SS) being the most common. Among the 70 cases successfully performed, it was identified that trisomy 3 was the most frequent molecular change (41/70, 58.6%), followed by trisomy 18 (7/70, 10%) and MALT1 translocation (5/70, 7.1%). The tumor tissue tended to exhibit trisomy 3 in patients without SS (p = 0.038). The 5‐year overall survival was 94.1%, and the 5‐year disease‐free survival was 85.3% (mean follow‐up time: 104.7 months). The patients without SS and trisomy 18 had a prolonged recurrence‐free survival (p = 0.015, p = 0.001 respectively). Conclusion Salivary gland MALT lymphoma is associated with autoimmune diseases, and trisomy 3 is the most common genetic change. Trisomy 18 can be used to predict the possibility of tumor relapse.

show abstract

Section: Discussionsupporting

confidence: 44%

Section: Discussionmentioning

confidence: 48%

Clinicopathological aspects of primary mucosa‐associated lymphoid tissue lymphoma of the salivary gland: A retrospective single‐center analysis of 72 cases

Zhang

Xia

et al. 2021

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…We found that Hashimoto thyroiditis and Chlamydia infection were associated with MZL in primary lymphoma of the thyroid and the ocular adnexa, respectively [24,37]. Furthermore, Sjögren syndrome appeared to be almost exclusively associated with MZL in primary salivary gland lymphoma [38]. In our current study, the infectious agent assessed (i.e.…”

Section: Discussionmentioning

confidence: 67%

Borrelia burgdorferi in primary cutaneous lymphomas: a systematic review and meta‐analysis

Travaglino

Varricchio

Pace

et al. 2020

J Deutsche Derma Gesell

Self Cite

View full text Add to dashboard Cite

Background: The association between Borrelia burgdorferi and primary cutaneous lymphoma is still unclear. This systematic review and meta-analysis aims to define the association of Borrelia burgdorferi with primary cutaneous lymphoma and its different entities. Methods: Electronic databases were searched for all studies that assessed the presence of Borrelia burgdorferi DNA in specimens of primary cutaneous lymphoma. The association between Borrelia and primary cutaneous lymphomas was assessed with an odds ratio (significant p < 0.05); cutaneous specimens with no lymphoproliferative disorders were used as controls. A secondary analysis was performed to assess the prevalence of Borrelia infection in different lymphoma entities. Results: Ten studies with 506 primary cutaneous lymphomas and 201 controls were included. The prevalence of Borrelia DNA positivity was highly heterogeneous among studies from different regions. Borrelia DNA positivity was significantly associated with primary cutaneous lymphomas (odds ratio = 10.88; p < 0.00001). The prevalence of Borrelia DNA positivity was similar among different entities (marginal zone: 7.3 %; follicular: 8.1 %; diffuse large B-cell: 7.5 %; mycosis fungoides: 8 %). Conclusions: Borrelia burgdorferi is significantly associated with primary cutaneous lymphomas, with no differences among the several lymphoma entities (both B-cell and T-cell), but with strong geographical differences. Molecular testing for Borrelia would be justified in patients with primary cutaneous lymphoma from endemic areas. Borrelia burgdorferi in primary cutaneous lymphomas: a systematic review and meta-analysis : Supporting information for this article is available on the WWW under

show abstract

“…A previous retrospective study has suggested that MALT lymphoma is a significant yet minor portion of pSS in salivary gland lymphoma (12), indicating that MALT lymphoma is one possible rather than the inevitable ending of pSS. Our study determines that even in one individual, the expression profiles in the salivary glands suffering from pSS exhibit heterogenous outcomes as time goes on (Figure 1B).…”

Section: Discussionmentioning

confidence: 98%

Characterization of comprehensive dynamic epigenetic changes during human primary Sjögren’s syndrome progression

Cao¹,

Shi²,

Chen³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Background: Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease characterized by reduced exocrine gland (principally the salivary and lacrimal glands) activity caused by chronic lymphocytic infiltration. Although pSS has been closely associated with an increased risk of mucosa-associated lymphoid tissue (MALT) lymphoma, the dynamic epigenetic changes in the gland cells that accompany the pathogenesis are not entirely understood.Methods: In this study, we harvested tissue samples from the labial gland with (LG_pSS) or without pSS (LG_NC) before MALT development, as well as the parotid gland with tumor tissues (PG_MALT) and paracancerous tissues (PG_NC) of two pSS patients with MALT lymphoma, and conducted RNA-seq and ChIP-seq for tri-methylated histone 3 lysine 4, 9, 27, 36, and 79 (H3K4/9/27/36/79me3).Results: Transcriptome landscapes indicated two outcomes of pSS progression with or without MALT lymphoma represented by distinct populations of differentially expressed genes and their functions. Furthermore, the epigenetic atlas of genome-wide H3K4/9/27/36/79me3 was in different stages for various samples, indicating that the variance of H3K4me3 was the earliest event, followed by selective alterations of H3K9/27/36/79me3. These four epigenetic modifications determine the final outcome of pSS progression. Conclusions:Our results not only advance the understanding of the dynamics of pSS progression and highlight the importance of epigenetic alterations in regulating transcription during this pathological process, but also identify potential therapeutic targets for pSS treatment and lymphoma intervention.

show abstract

Sjögren Syndrome in Primary Salivary Gland Lymphoma

Cited by 16 publications

References 48 publications

Clinicopathological aspects of primary mucosa‐associated lymphoid tissue lymphoma of the salivary gland: A retrospective single‐center analysis of 72 cases

Clinicopathological aspects of primary mucosa‐associated lymphoid tissue lymphoma of the salivary gland: A retrospective single‐center analysis of 72 cases

Borrelia burgdorferi in primary cutaneous lymphomas: a systematic review and meta‐analysis

Characterization of comprehensive dynamic epigenetic changes during human primary Sjögren’s syndrome progression

Contact Info

Product

Resources

About