Sjögren Syndrome and Pregnancy: A Literature Review

Gupta, Sanjeev; Gupta, Nikhil

doi:10.7812/tpp/16-047

Cited by 47 publications

(47 citation statements)

References 26 publications

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“…The authors suggest that this clinical correlation may be due to impaired placental vasculature remodeling in the setting of elevated IFNα concentrations. The high risk pregnancy for individuals with autoimmune disease extends beyond SLE and APS: rheumatoid arthritis is associated with low birth weight, mothers with systemic sclerosis have higher rates of preterm delivery and IUGR, and those with Sjogren’s disease have higher rates of miscarriage, preterm delivery, and low birth weight (Gupta and Gupta, 2017; Ostensen and Clowse, 2013).…”

Section: Introductionmentioning

confidence: 99%

Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development

2018

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Successful pregnancy requires carefully-coordinated communications between the mother and fetus. Immune cells and cytokine signaling pathways participate as mediators of these communications to promote healthy pregnancy. At the same time, certain infections or inflammatory conditions in pregnant mothers cause severe disease and have detrimental impacts on the developing fetus. In this review, we examine evidence for the role of maternal and fetal immune responses affecting pregnancy and fetal development, both under homeostasis and following infection. We discuss immune responses that are necessary to promote healthy pregnancy and those that lead to congenital disorders and pregnancy complications, with a particular emphasis on the role of interferons and cytokines. Understanding the contributions of the immune system in pregnancy and fetal development provides important insights into the pathogenesis underlying maternal and fetal diseases and sheds insights on possible targets for therapy.

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Section: Introductionmentioning

confidence: 99%

Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development

2018

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“… 4 pSS is a common autoimmune rheumatic condition, second only in frequency to rheumatoid arthritis, with a prevalence between 0.1% and 4.8% in various populations. 5 pSS has a negative influence on health-related quality of life (HR-QoL) 6 and is associated with high health care costs, 7 pain, 8 fatigue, 9 work disability, 10 and anxiety/depression. 11 Moreover, dry mouth in pSS may lead to oral uncomfortableness, trouble talking, impaired swallowing, tooth decay, and continual oral infections.…”

Section: Introductionmentioning

confidence: 99%

The impact of disease activity and psychological status on quality of life for Chinese patients with primary Sjögren’s syndrome

Cui

Xia

et al. 2018

PPA

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ObjectiveThe primary purpose of the present study was to survey the quality of life (QoL) in primary Sjögren’s syndrome (pSS) and to analyze the relationships between disease activity, anxiety/depression, fatigue, pain, age, oral disorders, impaired swallowing, sicca symptoms, and QoL.Patients and methodsA survey was conducted on 185 pSS patients and 168 healthy individuals using the Short Form 36 health survey for QoL. Disease activity was assessed using the European League Against Rheumatism Sjögren’s Syndrome Disease Activity Index. We examined these data using independent samples t-tests, Mann–Whitney U test, chi squared analysis, and linear regression.ResultsThe result for each domain in Short Form 36 health survey was lower in pSS patients than in healthy controls, especially the score in the dimension of role physical function. In the bivariate analysis, age, pain, fatigue, disease activity, disease complication, anxiety/depression, oral disorders, and impaired swallowing correlated with QoL. Also, in the linear regression model, pain, fatigue, disease activity, impaired swallowing, and anxiety/depression remained the main predictors of QoL.ConclusionpSS patients had a considerably impaired QoL compared to the controls, and pSS could negatively affect the QoL of patients. Measuring QoL should be considered as a vital part of the comprehensive evaluation of the health status of pSS patients, which could contribute some valuable clues in improving the management of disease and treatment decisions.

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“…These antibodies cross the placenta beginning at approximately 12 weeks of gestation and react with a fetal heart. When severe, this may be lethal, otherwise it can result in degeneration and endocardial fibroelastosis, disrupting conduction and leading to CHB [19], which is considered a major issue of fetal outcome. In fact, if left untreated, fetal and neonatal mortality due to CHB may develop [20].…”

Section: Pregnancymentioning

confidence: 99%

Lung complications of Sjogren syndrome

et al. 2020

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Primary Sjogren syndrome (pSS) is a systemic autoimmune disease characterised by lymphocytic infiltration of exocrine glands and by a number of systemic manifestations, including those regarding the lung. Pulmonary involvement in pSS includes interstitial lung disease (ILD) and airway disease, together with lymphoproliferative disorders.Patients with pSS-ILD report impaired health-related quality of life and a higher risk of death, suggesting the importance of early diagnosis and treatment of this type of pulmonary involvement. In contrast, airway disease usually has little effect on respiratory function and is rarely the cause of death in these patients.More rare disorders can be also identified, such as pleural effusion, cysts or bullae.Up to date, available data do not allow us to establish an evidence-based treatment strategy in pSS-ILD. No data are available regarding which patients should be treated, the timing to start therapy and better therapeutic options. The lack of knowledge about the natural history and prognosis of pSS-ILD is the main limitation to the development of clinical trials or shared recommendations on this topic. However, a recent trial showed the efficacy of the antifibrotic drug nintedanib in slowing progression of various ILDs, including those in pSS patients.

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Sjögren Syndrome and Pregnancy: A Literature Review

Cited by 47 publications

References 26 publications

Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development

Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development

The impact of disease activity and psychological status on quality of life for Chinese patients with primary Sjögren’s syndrome

Lung complications of Sjogren syndrome

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Sjögren Syndrome and Pregnancy: A Literature Review

Cited by 47 publications

References 26 publications

Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development

Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development

The impact of disease activity and psychological status on quality of life for Chinese patients with primary Sj&ouml;gren&rsquo;s syndrome

Lung complications of Sjogren syndrome

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The impact of disease activity and psychological status on quality of life for Chinese patients with primary Sjögren’s syndrome