Sjogren’s Syndrome: Recent Updates

Skarlis, Charalampos; Raftopoulou, Sylvia; Mavragani, Clio P.

doi:10.3390/jcm11020399

Cited by 10 publications

(8 citation statements)

References 32 publications

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“…Lymphomas are the most serious complication of pSS, with a consistent impact on the mortality rate of pSS patients. 82 , 83 Non-Hodgkin’s lymphoma (NHL) of mucosa-associated lymphoid tissue (MALT) is the usual histotype involving the major SGs in these patients. 66 The risk of NHL in patients with pSS is estimated to be increased 4 to 40-fold, resulting in the occurrence of NHL in about 5% of patients.…”

Section: Lymphomamentioning

confidence: 99%

Salivary Gland Ultrasound in Primary Sjögren’s Syndrome: Current and Future Perspectives

Lorenzon¹,

Spina²,

Franco³

et al. 2022

OARRR

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Salivary gland ultrasound (SGUS) is the imaging modality of choice for the assessment of parotid and submandibular gland parenchyma. Being highly effective, non-invasive and easy to perform, SGUS has become increasingly popular among specialists in assessing salivary gland (SG) abnormalities, including those commonly found in primary Sjögren’s syndrome (pSS). SGUS may be useful in the assessment of pSS and its complications, the most serious being the development of non-Hodgkin’s lymphoma (NHL). SGUS may also be useful in the characterization and differential diagnosis of diffuse and focal abnormalities commonly associated with pSS, and may act as a guide for core-needle biopsy (CNB), an established, safe, and feasible technique, which provides enough viable tissue for the diagnosis and assessment of lymphoproliferative diseases of the SG. The combination of SGUS with other tools, such as sonoelastography and artificial intelligence (AI), could further improve the usefulness of SGUS in the management of pSS. In this perspective, we summarize current and future applications of SGUS in pSS.

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Section: Lymphomamentioning

confidence: 99%

Salivary Gland Ultrasound in Primary Sjögren’s Syndrome: Current and Future Perspectives

Lorenzon¹,

Spina²,

Franco³

et al. 2022

OARRR

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“…Sjögren's syndrome (SS) is a long-course, inflammatory, immune-mediated, clinical condition caused by lymphocyte exocrine gland invasion [1]. Exocrine glands involved are the lacrimal and salivary glands with complaints of dryness of the eyes (xerophthalmia) and mouth (xerostomia) [2,3].…”

Section: Introductionmentioning

confidence: 99%

Sjögren’s Syndrome: An Incidental Radiologic Finding in a Patient with Aural Symptoms

Nwankwo¹,

Ajayi²,

Ayinde³

et al. 2023

Act Sci Otal

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Sjögren's syndrome, an immune-mediated disorder of the exocrine glands (lacrimal and salivary) affects acinar cell serous production leading to complaints of dryness of the eyes and mouth. Radiological imaging has been used as a non-invasive modality for the diagnosis of this condition. This is a case report of incidental diagnosis of Sjögren's syndrome in a 49-year-old female with left aural fullness and recurrent tinnitus. Incidental findings of scattered micro-calcifications and heterogeneity were seen in both parotid glands on computed tomography imaging and innumerable microcysts of low signal intensity on T1 and high signal intensity on T2/STIR, on magnetic resonance imaging of the temporal bone. These findings are pathognomonic for Sjögren's syndrome.The meticulous review of computed tomography and magnetic resonance images help to detect silent lesions and the awareness of audio-vestibular involvement in Sjögren's syndrome can lead to prompt diagnosis and the monitoring of disease progression.

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“…The pathological changes are due to the periductal lymphocytic infiltration and the consecutive progressive loss of the exocrine glands’ secretory function [ 1 , 2 ]. Patients with pSS have an increased risk (up to 40-fold higher than in the general population) of developing non-Hodgkin’s lymphoma, the main cause of pSS-related mortality [ 3 ]. Therefore, it is of paramount importance to choose the optimal imaging technique that allows us not only to diagnose this disease, but also to evaluate its stage and activity in order to start treatment as early as possible [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Value of MRI-Based Radiomic Analysis of Lacrimal Glands in Patients with Sjögren’s Syndrome

Muntean

Badarinza

Ștefan

et al. 2022

IJMS

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This study aimed to assess the effectiveness of MRI-based texture features of the lacrimal glands (LG) in augmenting the imaging differentiation between primary Sjögren’s Syndrome (pSS) affected LG and healthy LG, as well as to emphasize the possible importance of radiomics in pSS early-imaging diagnosis. The MRI examinations of 23 patients diagnosed with pSS and 23 healthy controls were retrospectively included. Texture features of both LG were extracted from a coronal post-contrast T1-weighted sequence, using a dedicated software. The ability of texture features to discriminate between healthy and pSS lacrimal glands was performed through univariate, multivariate, and receiver operating characteristics analysis. Two quantitative textural analysis features, RunLengthNonUniformityNormalized (RLNonUN) and Maximum2DDiameterColumn (Max2DDC), were independent predictors of pSS-affected glands (p < 0.001). Their combined ability was able to identify pSS LG with 91.67% sensitivity and 83.33% specificity. MRI-based texture features have the potential to function as quantitative additional criteria that could increase the diagnostic accuracy of pSS-affected LG.

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Sjogren’s Syndrome: Recent Updates

Abstract: Primary Sjögren’s syndrome (SS) is a chronic systemic autoimmune disorder affecting primarily perimenopausal women [...]

Cited by 10 publications

References 32 publications

Salivary Gland Ultrasound in Primary Sjögren’s Syndrome: Current and Future Perspectives

Salivary Gland Ultrasound in Primary Sjögren’s Syndrome: Current and Future Perspectives

Sjögren’s Syndrome: An Incidental Radiologic Finding in a Patient with Aural Symptoms

The Diagnostic Value of MRI-Based Radiomic Analysis of Lacrimal Glands in Patients with Sjögren’s Syndrome

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