Sjögren’s Syndrome Presenting as Recalcitrant Generalized Pruritus

Feuerman, E.J.

doi:10.1159/000254034

Cited by 14 publications

(2 citation statements)

References 18 publications

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“…Decreased sweating has been observed in SS patients, although pilocarpine stimulation tests have shown variable results. 1,3,[8][9][10] In a recent study, Katayama et al 11 reported statistically significant reductions in sweat volume in SS patients when compared with normal controls. On the other hand, in a series of 62 patients, Bloch et al did not observe histopathological lesions in the eccrine glands.…”

Section: Discussionmentioning

confidence: 99%

Lymphocytic autoimmune hidradenitis, cutaneous leucocytoclastic vasculitis and primary Sjögren's syndrome

Sais¹,

Admella²,

Fantova³

et al. 1998

British Journal of Dermatology

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We describe a 60-year-old woman with primary Sjögren's syndrome, mixed cryoglobulinaemia and cutaneous leucocytoclastic vasculitis who developed generalized hypohidrosis with a markedly decreased sweating response to pilocarpine chloride. Skin biopsies demonstrated dense peri-eccrine lymphocytic infiltrates in the lower reticular dermis, with glandular atrophy. From previous studies it is evident that although patients with Sjögren's syndrome commonly have skin dryness, a lymphocytic hidradenitis has been documented only in a few cases. The histological findings in this case support the role of autoimmune hidradenitis in the development of hypohidrosis in Sjögren's syndrome.

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