Sjögren’s syndrome

Abstract

Sjögren's syndrome (SjS) is an autoimmune disease characterized by the triad of sicca symptoms, fatigue and pain. This diagnosis is usually made in women at the average age of 60 years. Diagnosis is made when sicca symptoms persist for more than three months, after the exclusion of possible differential diagnoses, and using the ACR/ EULAR 2016 classification criteria for SjS. Many organs can be affected in the course of this disease. Xerosis cutis and pruritus are the most common skin manifestations, followed by leukocytoclastic vasculitis and subacute cutaneous lupus erythematosus. In addition, SjS patients often have myoarthralgia and neuropsychiatric symptoms. In the long term, attention must be paid to the increased risk of cardiovascular disease and lymphoma. Due to the multiorgan involvement in SjS patients, interdisciplinary care is required.

Erythematous annular macules in a patient with Sjögren syndrome

“…It has a very broad clinical spectrum and can affect multiple organs, including the skin, kidneys, and lungs. In the skin, SS can manifest as xeroderma, annular erythema, livedo reticularis, and vasculitis 2 …”

Exosomes in Action: Unraveling Their Role in Autoimmune Diseases and Exploring Potential Therapeutic Applications

“…Although some therapeutic drugs show some effect, they also increase the risk of infection and malignancy in patients. The cause and pathogenesis are not fully understood ( 45 46 ).…”

Erythematöse ringförmige Flecken bei einer Patientin mit Sjögren‐Syndrom

“…Es hat ein sehr breites klinisches Spektrum und kann mehrere Organe betreffen, darunter die Haut, die Nieren und die Lunge. An der Haut kann sich das SS als Xerodermie, ringförmiges Erythem, Livedo reticularis und Vaskulitis manifestieren 2 …”