Sjögren´s syndrome in present

Feltsan, T; Stanko, Peter; Mracna, J

doi:10.4149/bll_2012_116

Cited by 13 publications

(17 citation statements)

References 5 publications

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“…It also frequently affects many other organs and causes an array of symptoms and health complications, including B cell lymphoma245. SS can occur alone as primary SS or in conjunction with other inflammatory connective tissue diseases as secondary SS6. T and B cells are the main immune cell populations that infiltrate exocrine glands and are essentially required for the development and onset of SS78910.…”

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confidence: 99%

Endogenous programmed death ligand-1 restrains the development and onset of Sjӧgren’s syndrome in non-obese diabetic mice

Zhou

Jin²,

Kawai

et al. 2016

Sci Rep

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Programmed death-ligand 1 (PD-L1) down-modulates various immune responses by engaging the co-inhibitory receptor programmed death-1. Expression of PD-L1 and programmed death-1 is elevated in the salivary glands of patients with Sjögren’s syndrome (SS). The objective of this study is to define the role of endogenous PD-L1 in SS pathogenesis in non-obese diabetic (NOD) mouse model of this disease. We inhibited endogenous PD-L1 function by intraperitoneal administration of a blocking antibody to 6 week-old female NOD/ShiLtJ mice repeatedly during a 9-day period. PD-L1 blockade accelerated leukocyte infiltration and caspase-3 activation in the submandibular gland (SMG), production of antinuclear and anti-M3 muscarinic acetylcholine receptor (M3R) autoantibodies and impairment of saliva secretion, indicative of accelerated development and onset of SS. The effect of PD-L1 blockade was associated with increased T- and B cells and T helper 1 cytokine IFN-γ in the SMG. Local administration of exogenous IFN-γ to the SMG led to impaired salivary secretion accompanied by down-regulation of aquaporin 5 and an increase in anti-M3R autoantibodies. Conversely, neutralization of IFN-γ markedly improved salivary secretion and aquaporin 5 expression in anti-PD-L1-treated NOD/ShiLtJ mice. Hence, endogenous PD-L1 hinders the development and onset of SS in NOD mice, in part by suppressing IFN-γ production.

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confidence: 99%

Endogenous programmed death ligand-1 restrains the development and onset of Sjӧgren’s syndrome in non-obese diabetic mice

Zhou

Jin²,

Kawai

et al. 2016

Sci Rep

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“…Radiation treatments to head and neck can damage salivary glands, causing a marked decrease in saliva production (21) Sjögren's syndrome is an autoimmune disease characterized by dryness of the mouth and eyes. Autoimmune diseases feature the abnormal production of extra antibodies in the blood that are directed against various tissues of the body (22). The misdirected immune system in autoimmunity tends to lead to inflammation of tissues.…”

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confidence: 99%

“…Sjögren's syndrome that is also associated with a connective tissue disease, such as rheumatoid arthritis, systemic lupus erythematosus, or scleroderma, is referred to as secondary Sjögren's syndrome. Dryness of eyes and mouth, in patients with or without Sjögren's syndrome, is sometimes referred to as sicca syndrome (22)(23).…”

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confidence: 99%

“…Inflammation of the glands that produce tears (lacrimal glands) leads to decreased water production for tears and decreased saliva production and dry eyes. Inflammation of the glands that produce the saliva in the mouth (salivary glands, including the parotid glands) leads to dry mouth and dry lips (22)(23). Sjogren's syndrome with gland inflammation (resulting in dry eyes and mouth, etc.)…”

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confidence: 99%

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Update knowledge of dry mouth- A guideline for dentists

Altamimi¹

2014

Afr H. Sci.

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Background: Dry mouth is usually caused by a reduced salivary flow or by changes in the biochemical composition of saliva. Objective: The aim of this paper is a review of the update literature of dry mouth. Methods: We search in pubmed in the past 10 years using the words «dry mouth», «causes», «symptoms», «treatment» and «dentistry». A large number of papers have been identified. Papers not relevant to the issue were removed reducing the entries to 56 only. Results: There are no clearly established protocols for the treatment of dry mouth in the literature. Most of identified papers were systematic reviews, non-systematic reviews, and observational studies. The most studied patients were Sjögren's syndrome and the irradiated patients. Treatments are focused on the etiology, prevention, symptomatic, local salivary stimulation and systemic treatments. Conclusion: It can be concluded that there is no clear evidence for the causes and treatment of dry mouth, therefore the majority of the general dental practitioners refer most of the cases to appropriate specialist. Treatment must be individualized, salivary substitutes and mechanical stimulation techniques can be applied.

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“…SS is a systemic, chronic and autoimmune disease characterized by lymphocytic infiltration of all exocrine glands, espe- cially salivary and lacrimal glands [9]. It is called as primary SS if there is no underlying pathology.…”

Section: Discussionmentioning

confidence: 99%