Sjögren’s Syndrome Complicated With Sarcoidosis With a Repetitive, Prolonged, Non-productive Cough

Nakamura, Takahito; Watari, Takashi; Ohshima, Shiro; Katsushima, Utae; Muro, Shigeo

doi:10.7759/cureus.22827

Cited by 2 publications

(6 citation statements)

References 11 publications

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“…Sarcoidosis is a systemic granulomatous disease. CD4+ T cells interact with antigen-presenting cells to initiate the formation of granuloma plays a role in its pathogenesis 1 . Dyspnoea, which worsens with activity, persistent dry cough, chest pain; and wheezing are the manifestations of pulmonary sarcoidosis 11 .…”

Section: Discussionmentioning

confidence: 99%

“…Few studies have reported the coexistence of sarcoidosis and SS 1 , 6 , 12 , 13 There is a higher prevalence of articular and ocular involvement, anti-nuclear antibodies, rheumatoid factor, and positive anti-Ro/SSA antibodies in patients with coexisting sarcoidosis and SS 10 . Although anti-nuclear antibodies could be detected in sarcoidosis, anti-Ro/SSA antibodies were uncommon.…”

Section: Discussionmentioning

confidence: 99%

“…Sarcoidosis and primary Sjögren’s syndrome (pSS) are systemic immune diseases with similar clinical features 1 .…”

Section: Introductionmentioning

confidence: 99%

“…Sarcoidosis should be excluded before a diagnosis of Sjogren syndrome 3 . There are few reports of sarcoidosis coexisting with pSS 1 , 6 . A report from Taiwan in 2017, states that SS was significantly associated with sarcoidosis (adjusted odds ratio, 11.6; 95% CI, 4.36–31 1 .…”

Section: Introductionmentioning

confidence: 99%

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A case report of sarcoidosis overlapped with Sjogren’s syndrome

Kudsi,

Drie,

Khalayli

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction and importance: The diagnosis of sarcoidosis and Sjögren’s syndrome (SS) in the same patient is a challenge since sarcoidosis is considered an exclusion criterion for SS. Case presentation: The authors described a 62-year-old woman, who had SS for 8 years and presented with dry mouth, dry eyes, dyspnoea, and erythema nodosum. High resolution computed tomography of the chest showed symmetrical pulmonary micronodules, interstitial changes, and enlarged mediastinal lymph nodes. Anti-nuclear antibodies and anti-SSA antibodies were positive. Schermer’s test was also positive. A biopsy of lung nodules revealed non-caseous granuloma. Salivary gland biopsy showed focal lymphocyte infiltration. Diagnosis of sarcoidosis and SS were done according to the classification criteria in this patient. Clinical discussion: Although the diagnosis of Sjogren requires the exclusion of conditions that cause dry eyes and mouth, such as sarcoidosis, Few studies have reported the coexistence of sarcoidosis and SS such as this case report. Conclusion: This case extends our understanding of overlapped SS with sarcoidosis and provides a referential value for clinical diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Sarcoidosis and primary Sjögren’s syndrome (pSS) are systemic immune diseases with similar clinical features 1 .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A case report of sarcoidosis overlapped with Sjogren’s syndrome

Kudsi,

Drie,

Khalayli

et al. 2023

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

show abstract

“…In two thirds of cases, sarcoidosis was diagnosed concomitantly with SS or during the follow-up of patients with an already diagnosed SS while a superimposed diagnosis of SS during the follow-up of patients firstly diagnosed with sarcoidosis was less frequently observed. To date, less than 39 cases of coexisting SS with sarcoidosis had been reported (Supplementary Table S1) (13,(21)(22)(23)(24)(25)(26)(27)(28). Therefore, the coexistence of the two diseases should be considered a rare event.…”

Section: Discussionmentioning

confidence: 99%

Characterisation of the coexistence between sarcoidosis and Sjögren's syndrome. Analysis of 43 patients

Flores-Chávez

Ng²,

Alunno

et al. 2022

Clinical and Experimental Rheumatology

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ObjectiveTo characterise the key epidemiological, clinical, immunological, imaging, and pathological features of the coexistence between sarcoidosis and Sjögren's syndrome (SS). Methods All centres included in two large multicentre registries (the Sjögren Syndrome Big Data Consortium and the Sarco-GEAS-SEMI Registry) were contacted searching for potential cases of coexistence between SS and sarcoidosis seen in daily practice. Inclusion criteria were the fulfilment of the current classification criteria both for SS (2016 ACR/EULAR) and sarcoidosis (WASOG). The following featureswere considered for evaluating a coexisting immunopathological scenario between the two diseases: non-caseating granulomas (NCG), focal lymphocytic sialadenitis (FLS) and positive anti-Ro antibodies. Results We identified 43 patients who fulfilled the inclusion criteria (38 women, with a mean age of 53 years at diagnosis of SS and of 52 years at diagnosis of sarcoidosis). In 28 (65%) cases, sarcoidosis was diagnosed concomitantly with SS, or during the follow-up of patientswith an already diagnosed SS, while in the remaining 15 (35%), SS was diagnosed during the follow-up of an already diagnosed sarcoidosis. Patients in whom sarcoidosis was diagnosed first showed a lower mean age (43.88 vs. 55.67 years, p=0.005) and were less frequently women (73% vs. 96%, p=0.04) in comparison with those in whom sarcoidosis was diagnosed concomitantly with SS, or during the follow-up of an already diagnosed SS. We identified the following immunopathological scenarios: a combination of NCG involving extrasalivary tissues and anti-Ro antibodies in 55% of patients, a coexistence of both pathological scenarios (extrasalivary NCG and FLS in MSGB) in 42% (with positive anti-Ro antibodies in two thirds of cases), and NCG involving salivary glands and anti-Ro antibodies in 3% of cases. ConclusionWe have characterised the largest reported series of patients who fulfilled the current classification criteria for both SS and sarcoidosis. This implies that sarcoidosis (and not just the presence of isolated NCG on salivary gland biopsy) may, like other systemic autoimmune diseases, coexist with SS, and that a sarcoidosis diagnosis does not preclude the development of SS in the future.

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Sjögren’s Syndrome Complicated With Sarcoidosis With a Repetitive, Prolonged, Non-productive Cough

Cited by 2 publications

References 11 publications

A case report of sarcoidosis overlapped with Sjogren’s syndrome

A case report of sarcoidosis overlapped with Sjogren’s syndrome

Characterisation of the coexistence between sarcoidosis and Sjögren's syndrome. Analysis of 43 patients

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