Sjögren's syndrome associated with multiple myeloma

Abstract

Sjögren's syndrome (SS) is a chronic autoimmune disease of unknown etiology characterized by lymphocytic infiltration of the exocrine glands and a polyclonal B-cell activation; it is demonstrated by the presence of multiple autoantibodies against organ- and non-organ-specific autoantigens. SS is associated with malignant lymphomas, Waldenstrom's macroglobulinemia and benign monoclonal gammopathy, while its relationship with multiple myeloma is extremely rare. The association between multiple myeloma and rheumatoid arthritis and other autoimmune diseases has been established, but it is not clear why a B-cell proliferation like myeloma occurs more rarely than other B-cell disorders in patients with SS. We describe a patient who presented with multiple myeloma and SS that might have existed for at least 2 years prior to the appearance of myeloma.

Different biological behaviour of Waldenström macroglobulinemia in two dogs

“…BJ proteinuria was not included in the diagnostic criteria for the following issues. Firstly, as reported by others 27 and also in our experience, Globulin (g dl -1 ) 9 1 0 1 1 8.5 9 9.5 10 10.5 Total protein (g dl -1 ) 11 11.5 12 12.5 Figure 3. The data refer to case 1: Graph ics represent the best fitted exponential curve between serum viscocity (SV) and total protein, globulin and M-component.…”

“…10 The monoclonal component may also cause, as a consequence of autoantibody activity, immune mediated phenomena, such as cryoglobulinemia peripheral neuropathies and cold agglutinin haemolytic anaemia. 3,11,12 Common laboratory findings both in humans and dogs are anaemia, leukocytosis/leukopenia, pancytopenia, hypergammaglobulinemia of IgM type, cryoglobulinemia and Bence-Jones (BJ) proteinuria. 3,13,14 Possible secondary reported complications associated with WM include a second neoplasm, infection (sepsis) and progressive renal insufficiency.…”

Incidence of cancer in a nationwide population cohort of 7852 patients with primary Sjögren's syndrome in Taiwan

“…The association between pSS and MM has been suggested in case reports 28–30. The hypothesis was based on the observation that many patients with pSS had benign monoclonal gammopathy, and the association between benign monoclonal gammopathy and MM was well established.…”

Mikulicz’s disease with severe thrombocytopenia following autologous stem cell transplantation in a multiple myeloma patient

“…Wada et al [9] reported a case of MM complicated by autoimmune hemolytic anemia. Terpos et al [10] also reported a case of MM developing SS. However, these case reports could not show a true association between disease activity of MM and subsequent autoimmune disorders.…”