Sjögren's syndrome – an update for dental practitioners

Carr, Alison; Ng, Wan‐Fai; Figueiredo, FC; Macleod, R I; Greenwood, Mark; Staines, Konrad

doi:10.1038/sj.bdj.2012.890

Cited by 37 publications

(31 citation statements)

References 25 publications

(30 reference statements)

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“…It may show as a primary disease without any other accompanying symptoms or as a secondary disease appearing simultaneously with other autoimmune diseases such as rheumatoid arthritis, lupus erythematosus, dermatomyelitis, scleroderma, and primary cirrhosis of the liver. Sjögren syndrome also shows a tendency towards fibromyalgia, migraines, hypothyroidism, Raynaud symptom, and lymphomas [1][2][3][4][5][6][7][8][9][10][11][12]. One of the most bothering symptoms of the syndrome is xerostomia.…”

Section: Discussionmentioning

confidence: 99%

Oral mucosal manifestations in primary and secondary Sjögren syndrome and dry mouth syndrome

Błochowiak¹,

Olewicz‐Gawlik²,

Polańska³

et al. 2016

pdia

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Introduction One of the most important symptoms of Sjögren syndrome is xerostomia. The oral cavity deprived of saliva and its natural lubricative, protective and antibacterial properties is prone to a number of unfavourable consequences. Aim To present the most important lesions on the oral mucosa in primary and secondary Sjögren syndrome and in dry mouth syndrome. Material and methods The study group comprised 55 patients including 52 women and 3 men aged 20–72 years (average: 28.25 years). Results Basing on the accepted criteria, primary Sjögren syndrome was diagnosed in 22 (40%) patients, secondary Sjögren syndrome in 18 (32.7%) patients, and dry mouth syndrome in 15 (27.27%) patients. The physical examination and the examination of the mouth were performed and history was elicited from every patient. Conclusions The most common pathologies appearing on the oral mucosa in primary and secondary Sjögren syndrome are angular cheilitis, cheilitis, increased lip dryness as well as non-specific ulcerations, aphthae and aphthoid conditions.

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Section: Discussionmentioning

confidence: 99%

Oral mucosal manifestations in primary and secondary Sjögren syndrome and dry mouth syndrome

Błochowiak¹,

Olewicz‐Gawlik²,

Polańska³

et al. 2016

pdia

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“…X erostomia or dry mouth is one of the characteristic features of Sjögren's Syndrome (SS) and affects several aspects of oral health (Carr et al, 2012). The lack of sufficient saliva often leads to an increased incidence of dental caries and periodontal disease, necessitating frequent interventions by a dental professional.…”

mentioning

confidence: 99%

Type I Interferon Receptor Deficiency Prevents Murine Sjögren’s Syndrome

et al. 2013

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In Sjögren's Syndrome (SS), inherent glandular defects, autoimmunity, and mononuclear cell infiltration within the salivary glands cause reduced salivation leading to xerostomia. Excessive production of type I interferons (IFN), triggered by environmental and genetic factors, is considered pathogenic in this disorder. However, whether type I IFN production is causative or an outcome of the disease process is not known. To address this question, we introduced a deficiency of interferon alpha receptor 1 (Ifnar1) into B6.Aec1Aec2 mice, which are known to have the genetic loci necessary for developing a SS-like disorder. This new mouse strain, B6.Aec1Aec2Ifnar1 -/-, lacking type I IFN-mediated signaling, was characterized for pilocarpine-induced salivation, the presence of serum autoantibodies, sialoadenitis, and dacryoadenitis. Compared with the B6.Aec1Aec2Ifnar1 +/+ (wild-type) mice, the B6.Aec1Aec2Ifnar1 -/-(knockout) mice had significantly lower mononuclear cell infiltration in the salivary and lacrimal glands. The knockout mice were completely protected from salivary gland dysfunction. Surprisingly, they had a robust autoantibody response comparable with that of the wild-type mice. These findings demonstrate that, in the absence of type I IFN-mediated signaling, systemic autoantibody responses can be dissociated from glandular pathology. Our study suggests that, in genetically susceptible individuals, the type I IFN pathway can instigate certain features of SS.

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“…In practice, we required the patients to fulfill the criteria for pSS and, additionally, the American College of Rheumatology criteria for an established CTD such as RA, SLE or mixed CTD (MCTD). [6][7][8][9] The patients were recruited consecutively in 2013 from the Department of Rheumatology and Clinical Immunology at Poznan University of Medical Sciences, Poland. Exclusion criteria included: previous radiotherapy to the head and neck, lymphoma, sarcoidosis, graft-versus-host disease, infections of the hepatitis C virus, human T-lymphotropic virus type I and HIV.…”

Section: Study Groupsmentioning

confidence: 99%