Sjögren’s syndrome

Amarasena, Roshan; Bowman, Simon

doi:10.7861/clinmedicine.7-1-53

Cited by 16 publications

(4 citation statements)

References 8 publications

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“…sSS usually is a consequence of some other rheumatic disease, for example systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). pSS is otherwise already a disease by itself [2]. SS occurs worldwide with similar prevalence (0.5-1.5%) and around 90% of the patients are female.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Profiling of Saliva in Patients with Primary Sj?gren?s syndrome

Mikkonen¹

2012

Metabolomics

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Volume 3 • Issue 3 • 1000128and promising approach to identify biomarkers associated with several disorders such as celiac disease [6,7], leukemia [8], breast cancer [9,10] and oral carcinomas [11]. A variety of different analytical techniques have been used in the metabolic profiling studies: currently the mass spectrometry (MS) has been utilized most frequently. Among MS techniques, especially two-dimensional gel electrophoresis (2D-GE) and matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) have mostly been applied to analyze SS saliva samples [12][13][14][15][16].Instead, another powerful metabolic profiling technique, namely nuclear magnetic resonance (NMR) spectroscopy, has remained largely underexplored in saliva analysis. Although some salivary metabolites have been successfully identified and inter-and intrasubject variability has been investigated by using 1 H NMR [17][18][19][20][21] or 13 C NMR spectroscopy [22], well-designed studies aiming to biomarker identification associated to certain health disorder are very rare [23]. AbstractObjective: To investigate the feasibility of 1 H-NMR spectroscopy for metabolic profiling of human saliva samples and to determine whether the concentration of certain salivary metabolites, mainly representing small organic acids and amino acids, differ between patients with primary Sjögren´s syndrome (pSS) and healthy controls.Methods: Stimulated whole-mouth saliva (SWMS) was collected from female pSS patients (n =15, all fulfilling the revised European Community proposed criteria). Salivary flow rate was immediately determined, samples were then frozen and subsequently analyzed by 1 H-NMR spectroscopy in comparison with samples collected from healthy individuals (n=15).Results: From each sample, up to 24 metabolites could be identified and quantified. Choline and taurine concentrations were very significantly higher in the pSS patients compared to healthy controls (p<0.001), but their concentrations correlated negatively with salivary flow rate. Alanine and glycine concentrations were significantly higher (p=0.004, p=0.007, respectively), whereas butyrate (p= 0.034), phenylalanine (p=0.026) and proline (p=0.032) were only slightly higher in pSS saliva samples than in controls.Conclusions: NMR spectroscopy has a potential for quantitative metabolic profiling of saliva samples. NMR spectroscopy is suitable for the analysis of NAAs in saliva and it can bypass the other methods, which are normally suitable for analysis of just one metabolite. Me ta b o lo m ics: O p e n A c ce ss

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Section: Introductionmentioning

confidence: 99%

Metabolic Profiling of Saliva in Patients with Primary Sj?gren?s syndrome

Mikkonen¹

2012

Metabolomics

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“…SS is an autoimmune disease that causes chronic inflammation and primarily affects the exocrine glands [ 1 , 2 ]. Because it is a systemic disease, SS can also exhibit a wide range of clinical manifestations.…”

Section: Discussionmentioning

confidence: 99%

“…Dryness of the eyes (xerophthalmia leading to keratoconjunctivitis sicca) and mouth (xerostomia) constitute the typical clinical condition of this syndrome [1,2]. SS may also cause chronic multiple lymphadenopathy due to its lymphoproliferative characteristics.…”

Section: Introductionmentioning

confidence: 99%

“…Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disease characterized by progressive lymphocytic infiltration of the exocrine glands and other extra-glandular structures [ 1 ]. Dryness of the eyes (xerophthalmia leading to keratoconjunctivitis sicca) and mouth (xerostomia) constitute the typical clinical condition of this syndrome [ 1 , 2 ]. SS may also cause chronic multiple lymphadenopathy due to its lymphoproliferative characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Clinically Positive Axillary Lymphadenopathy May Lead to False Diagnosis of Overstaged Breast Cancer in Patients with Sjögren's Syndrome: A Case Report

Cipe

Genç

et al. 2011

J Breast Cancer

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Sjögren's syndrome (SS) is an autoimmune disease that chronic inflammation and lymph node proliferation. Patients with SS carry a greater risk of developing lymphoproliferative malignancy. In addition to other organ cancers, breast cancer may also occur in these patients. Considering these, breast cancer in patients with SS can be misdiagnosed as being in an advanced stage particularly in the presence of axillary lymphadenopathy. Here, we report a rare case of a 45-year-old woman with SS who presented with a breast mass. Radiology showed a 4 cm solid lesion and conglomerates of axillary lymphadonepathy. A breast biopsy revealed ductal carcinoma in situ. A modified radical mastectomy was performed; however, no axillary metastases were detected. Clinicians should remain vigilant to the possibility that a false clinical impression of axillary metastasis may occur in such patients with breast cancer. Therefore, axillary node status should be verified first.

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Oral Signs of Connective Tissue Disease

Heath

Fazel

2019

Oral Signs of Systemic Disease

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Sjögren’s syndrome

Cited by 16 publications

References 8 publications

Metabolic Profiling of Saliva in Patients with Primary Sj?gren?s syndrome

Metabolic Profiling of Saliva in Patients with Primary Sj?gren?s syndrome

Clinically Positive Axillary Lymphadenopathy May Lead to False Diagnosis of Overstaged Breast Cancer in Patients with Sjögren's Syndrome: A Case Report

Oral Signs of Connective Tissue Disease

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