Sjögren's Syndrome

Papiris, Spyros; Tsonis, Ioannis; Moutsopoulos, Haralampos Μ.

doi:10.1055/s-2007-985667

Cited by 45 publications

(19 citation statements)

References 88 publications

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“…Sjögren's syndrome (SS) is a systemic autoimmune disease in which the immune response is activated to attack and destroy the exocrine glands that produce tears and saliva [1,2]. The disease may be isolated (primary SS [pSS]) or may occur in association with other rheumatic diseases (secondary SS [sSS]), such as rheumatoid arthritis (RA), scleroderma (SSc), and systemic lupus erythematosus (SLE).…”

Section: Introductionmentioning

confidence: 99%

A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren’s syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14

et al. 2016

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Novel autoantibodies against nuclear antigen of 14 kDa (NA-14)/Sjögren's syndrome nuclear antigen-1 (SSNA-1) are predominantly recognized in sera of patients with primary Sjögren's syndrome (pSS). However, the detailed characteristics of the anti-NA-14 antibody remain unknown. Here, we sought to clarify the characteristics of anti-SSNA-1/NA-14 antibodies and the mechanisms of autoantibody production using sera from patients with connective tissue diseases (including pSS), autoimmune sera reacting with standard autoantigens (SS-A/Ro and/or SS-B/La, ds DNA, Scl-70 and Jo-1), and normal healthy controls (NHCs). Anti-NA-14 antibodies were predominantly recognized in sera from patients with pSS and in autoimmune sera reacting with thSS-A/Ro and/or -SS-B/Lo. Indirect immunofluorescence analysis showed that NA-14 was strongly expressed in mitotic-phase cells. Patients with pSS having anti-NA-14 antibodies exhibited significant elevation of serum IP-10 and BAFF compared to that in patients with pSS without anti-NA-14 antibodies and NHCs. Thus, our data demonstrated that anti-NA-14 antibodies could be classified as novel autoantibodies reacting with mitosis-related autoantigens predominantly recognized in pSS. Moreover, interferon-γ played an important role in the production of anti-NA-14 autoantibodies as patients with pSS having anti-NA-14 antibodies exhibited increased serum levels of IP-10 and BAFF.

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Section: Introductionmentioning

confidence: 99%

A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren’s syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14

et al. 2016

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“…Sjögren’s syndrome (SS) is a member of the family of systemic autoimmune diseases, in which the immune response is activated to recognize a limited subset of ubiquitously expressed self antigens (1,2). Although SS is characterized primarily by chronic sialadenitis and dacryoadenitis, a variety of systemic manifestations have been described.…”

Section: Introductionmentioning

confidence: 99%

Autoantibody to NA14 is an independent marker primarily for Sjögren's syndrome

Nozawa

Ikeda²,

Satoh³

et al. 2009

Front Biosci

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Nuclear Autoantigen of 14 kDa (NA14) was originally identified using the serum of a Sjögren’s syndrome (SS) patient as probe in screening a human testis cDNA expression library. To date there is no report in the systematic analysis of the prevalence of autoantibodies to NA14. In this study, anti-NA14 was determined in several rheumatic diseases from independent cohorts in the US and Japan. The prevalence of anti-NA14 were 18/132 (13.6%) in primary SS, 0/50 (0%) secondary SS, 2/100 (2%) SLE, 1/43 (2.3%) scleroderma, 0/54 (0%) rheumatoid arthritis, 1/29 (3.4%) polymyositis/dermatomyositis, and 0/58 (0%) normal healthy controls. The frequencies of anti-NA14 positive sera in primary SS are statistically greater than normal healthy controls (p=0.006), secondary SS (p=0.044), and other rheumatic diseases. Furthermore, among 11 anti-NA14 positive primary SS sera, 4/11 (36.3%) sera were negative for both anti-SS-A/Ro and SS-B/La antibodies. Thus anti-NA14 autoantibodies may be useful for the discrimination of primary versus secondary SS and serve as a diagnostic marker for primary SS especially in seronegative (anti-SS-A/Ro and anti-SS-B/La antibodies negative) patients with SS.

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“…Primary Sjögren's syndrome (SS) is a systemic autoimmune disorder characterized by exocrine failure of salivary and lacrimal glands (sicca syndrome) and extraglandular features, including gastrointestinal (GI) dysfunction (1)(2)(3)(4). Impairment of the GI tract in primary SS is widespread, and includes reduced esophageal motor function (5,6), delayed gastric emptying (7), and abnormalities in colonic motility (3).…”

mentioning

confidence: 99%

Antibodies interfering with the type 3 muscarinic receptor pathway inhibit gastrointestinal motility and cholinergic neurotransmission in Sjögren's syndrome

Park¹,

Haberberger²,

Gordon³

et al. 2011

Arthritis & Rheumatism

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Objective. In primary Sjögren's syndrome (SS), impairment of the gastrointestinal (GI) tract is common, and includes reduced esophageal motor function, delayed gastric emptying, and abnormalities in colonic motility; the pathogenesis is as yet unknown. We undertook this study to investigate the role of functional antibodies to the type 3 muscarinic receptor (M3R) in GI dysfunction associated with primary SS.Methods. Muscle strip and whole-organ functional assays were used to determine whether IgG with anti-M3R activity from patients with primary SS disrupted neurotransmission in tissue from throughout the mouse GI tract. Specificity of the autoantibody for the M3R was determined using knockout mice that were deficient in the expression of muscarinic receptor subtypes.Results. Functional antibodies to the M3R inhibited neuronally mediated contraction of smooth muscle from throughout the GI tract and disrupted complex contractile motility patterns in the colon. The autoantibodies were not active on tissue from mice that lacked the M3R, providing compelling evidence of the direct interaction of patient autoantibodies with the M3R.Conclusion. Our results indicate that anti-M3R autoantibodies have the potential to mediate multiple dysfunctions of the GI tract in primary SS, ranging from reduced esophageal motor activity to altered colonic motility. We hypothesize that altered GI motility forms part of a broader autonomic dysfunction mediated by pathogenic anti-M3R autoantibodies in primary SS.

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Sjögren's Syndrome

Cited by 45 publications

References 88 publications

A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren’s syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14

A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren’s syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14

Autoantibody to NA14 is an independent marker primarily for Sjögren's syndrome

Antibodies interfering with the type 3 muscarinic receptor pathway inhibit gastrointestinal motility and cholinergic neurotransmission in Sjögren's syndrome

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