Sjögren–Larsson syndrome caused by novel mutations in ALDH3A2 gene

Abstract

reaction and release of fibroblast growth factors. Rarely, particles from dental implants may cause a similar reaction. 4 To the best of our knowledge, only one similar case of cutaneous metallosis was published, until now, describing multiple cutaneous nodules with lymphedema, subsequently attributed to metal debris reaction after orthopedic surgery. 2 Herein, we describe, for the first time in the literature, an intriguing case of the darkly pigmented subcutaneous nodule due to metallosis which was histopathologically misdiagnosed as a melanoma metastasis. However, a detailed history from the patient warranted revision of histopathological analysis which surprisingly revealed a completely benign condition called metallosis.