Size of the Optic Nerve Head and Its Relationship with the Thickness of the Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in Patients with Primary Open Angle Glaucoma

Enomoto, Nobuko; Anraku, Ayako; Ishida, Kyoko; Takeyama, Asuka; Yagi, Fumihiko; Tomita, Goji

doi:10.1155/2015/186249

Cited by 6 publications

(4 citation statements)

References 45 publications

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“…Studies evaluating differences between patients with parafoveal and peripheral scotoma [2, 3, 13–17, 26] found no differences in the optic disc area between the two groups. However, in our previous study [27], we found that the thicknesses of cpRNFL and mGCC were significantly positively correlated with the disc area in eyes with glaucoma. Smaller discs may have thinner cpRNFL and mGCC and be susceptible to the inferior VF defect.…”

Section: Discussionmentioning

confidence: 61%

Factors Related to Superior and Inferior Hemifield Defects in Primary Open-Angle Glaucoma

Takeuchi

Enomoto

Ishida

et al. 2019

Journal of Ophthalmology

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Purpose. We aimed to investigate factors related to superior and inferior hemifield defects in primary open-angle glaucoma (POAG). Methods. Sixty-seven subjects with newly diagnosed, untreated POAG underwent optical coherence tomography (OCT) of the disc area, macular ganglion cell complex (mGCC), and circumpapillary retinal nerve ﬁber layer (cpRNFL) thickness within 6 months of the visual field (VF) test. Based on the VF and OCT results, 40 subjects had a superior and 27 an inferior hemiﬁeld defect. Clinical data including visual acuity, refractive error, disc hemorrhage, VF indexes, and medical history were recorded. Results. Average mGCC thickness corresponding to the defective hemifields was thinner in the superior VF defect group than in the inferior VF defect group (P=0.003). Average total deviation (TD) was comparable between the two groups. However, the superior VF defect group had a higher prevalence of defects (P=0.001) and lower TD (P=0.002) within central 5 degrees of VF than the inferior VF defect group. In multivariate regression analyses, the temporal-lower and inferior-temporal cpRNFL thicknesses were significant contributing factors to the inferior mGCC thickness in the superior VF defect group. In the inferior VF defect group, the disc area, family history of glaucoma, and temporal-upper cpRNFL thickness contributed to the superior mGCC thickness. Conclusion. The inferior mGCC thickness corresponding to the superior hemifield defect group was significantly thinner than the superior mGCC thickness corresponding to the inferior hemifield defect group. The factors related to the reduction of the corresponding mGCC thickness may differ between superior VF defect and inferior VF defect groups.

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Section: Discussionmentioning

confidence: 61%

Factors Related to Superior and Inferior Hemifield Defects in Primary Open-Angle Glaucoma

Takeuchi

Enomoto

Ishida

et al. 2019

Journal of Ophthalmology

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“…Our data suggest that optical discs with larger area have greater MCD and MD. The relationship between disc area and susceptibility to glaucomatous damage remains to be clarified [19]. Some authors suggest that patients with large discs have a higher incidence of glaucoma [20] [21], while others have found no such relationship [22] [23].…”

Section: Discussionmentioning

confidence: 99%

Age, Maximum Cup Depth, Central Corneal Thickness, Disc Area and Mean Defect in Patients with Open Angle Glaucoma and Ocular Hypertension

Díaz-Alemán¹,

González-Hernández²,

Ángel-Pereira³

et al. 2016

OJOph

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Purpose: The main objective was to analyze the relationship between maximum cup depth (MCD), mean defect (MD), central corneal thickness (CCT), age and disc area, in patients with ocular hypertension (OHT) and primary open angle glaucoma (POAG). Methods: Cross-sectional study of patients diagnosed with OHT and POAG. Visual fields were obtained using an Octopus 300 analyzer, TOP strategy. MCD and disc area were obtained using a Heidelberg Retina Tomograph. Results: The study sample comprised 234 eyes of 143 patients, 91 women and 52 men, mean age 63.55 years (SD 10.49). Mean values were: MCD 0.52 mm (SD 0.27), MD 2.78 dB (SD 5.02), CCT 543.5 µm (SD 36.63), IOP 16. 73 mmHg (SD 2.93), and disc area 2.01 mm 2 (SD 0.39). A significant correlation was observed between MCD and age in patients under 60 years, between MCD and disc area, and between MD and disc area. Conclusions: Our study showed a correlation between MCD and age which was significant in patients under 60 years of age, between MCD and disc area and between MD and disc area, suggesting that the larger the disc area, the greater the MCD and the MD in patients with OHT and POAG.

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“…Novel research suggests that peripapillary RNFL alterations are detected with OCT earlier than with conventional methods such as visual field testing. 60 Furthermore, the peripapillary RNFL can be compared with the macular RNFL thickness and ganglion cell layer thickness to potentially monitor disease progression. Using OCT RNFL thickness analysis, some authors have reported a reduced thickness of the peripapillary RNFL in children affected with NF1 who have optic nerve gliomas.…”

Section: Ophthalmic and Adenexal Manifestationsmentioning

confidence: 99%

Neurofibromatosis: an update of ophthalmic characteristics and applications of optical coherence tomography

Abdolrahimzadeh¹,

Piraino²,

Albanese³

et al. 2016

OPTH

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Neurofibromatosis (NF) is a multisystem disorder and tumor predisposition syndrome caused by genetic mutation on chromosome 17-17q11.2 in NF type 1 (NF1), and on chromosome 22-22q12.2 in NF type 2. The disorder is characterized by considerable heterogeneity of clinical expression. NF1 is the form with the most characteristic ocular manifestations. Lisch nodules of the iris are among the well-known diagnostic criteria for the disease. Glaucoma and associated globe enlargement have been described in a significant proportion of patients with NF1 and orbital–facial involvement. Optic nerve glioma may cause strabismus and proptosis, and palpebral neurofibroma may reach considerable size and occasionally show malignant transformation. Near infrared reflectance has greatly contributed to enhancing our knowledge on choroidal alterations in NF1. Indeed, some authors have proposed to include these among the diagnostic criteria. Optical coherence tomography has given new insight on retinal alterations and is a noninvasive tool in the management of optic nerve gliomas in children. Ocular manifestations in NF type 2 can range from early-onset cataracts in up to 80% of cases to optic nerve hamartomas and combined pigment epithelial and retinal hamartomas.

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Size of the Optic Nerve Head and Its Relationship with the Thickness of the Macular Ganglion Cell Complex and Peripapillary Retinal Nerve Fiber Layer in Patients with Primary Open Angle Glaucoma

Cited by 6 publications

References 45 publications

Factors Related to Superior and Inferior Hemifield Defects in Primary Open-Angle Glaucoma

Factors Related to Superior and Inferior Hemifield Defects in Primary Open-Angle Glaucoma

Age, Maximum Cup Depth, Central Corneal Thickness, Disc Area and Mean Defect in Patients with Open Angle Glaucoma and Ocular Hypertension

Neurofibromatosis: an update of ophthalmic characteristics and applications of optical coherence tomography

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